Deciphering Urogenital Cancers through Proteomic Biomarkers: A Systematic Review and Meta-Analysis
Urogenital cancers, which include prostate, bladder, and kidney malignancies, exert a substantial impact on global cancer-related morbidity and mortality. Proteomic biomarkers, emerging as valuable tools, aim to enhance early detection, prognostic accuracy, and the development of personalized therap...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/16/1/22 |
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| author | Aafaque Ahmad Khan Nahad Al-Mahrouqi Aida Al-Yahyaee Hasan Al-Sayegh Munjid Al-Harthy Shoaib Al-Zadjali |
| author_facet | Aafaque Ahmad Khan Nahad Al-Mahrouqi Aida Al-Yahyaee Hasan Al-Sayegh Munjid Al-Harthy Shoaib Al-Zadjali |
| author_sort | Aafaque Ahmad Khan |
| collection | DOAJ |
| description | Urogenital cancers, which include prostate, bladder, and kidney malignancies, exert a substantial impact on global cancer-related morbidity and mortality. Proteomic biomarkers, emerging as valuable tools, aim to enhance early detection, prognostic accuracy, and the development of personalized therapeutic strategies. This study undertook a comprehensive systematic review and meta-analysis of the existing literature investigating the role and potential of proteomic biomarkers in plasma, tissue, and urine samples in urogenital cancers. Our extensive search across several databases identified 1879 differentially expressed proteins from 37 studies, signifying their potential as unique biomarkers for these cancers. A meta-analysis of the significantly differentially expressed proteins was executed, accentuating the findings through visually intuitive volcano plots. A functional enrichment analysis unveiled their significant involvement in diverse biological processes, including signal transduction, immune response, cell communication, and cell growth. A pathway analysis highlighted the participation of key pathways such as the nectin adhesion pathway, TRAIL signaling pathway, and integrin signaling pathways. These findings not only pave the way for future investigations into early detection and targeted therapeutic approaches but also underscore the fundamental role of proteomics in advancing our understanding of the molecular mechanisms underpinning urogenital cancer pathogenesis. Ultimately, these findings hold remarkable potential to significantly enhance patient care and improve clinical outcomes. |
| first_indexed | 2024-03-08T15:10:03Z |
| format | Article |
| id | doaj.art-0f613ed141c2446796482925b8723cab |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-08T15:10:03Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-0f613ed141c2446796482925b8723cab2024-01-10T14:52:20ZengMDPI AGCancers2072-66942023-12-011612210.3390/cancers16010022Deciphering Urogenital Cancers through Proteomic Biomarkers: A Systematic Review and Meta-AnalysisAafaque Ahmad Khan0Nahad Al-Mahrouqi1Aida Al-Yahyaee2Hasan Al-Sayegh3Munjid Al-Harthy4Shoaib Al-Zadjali5Research Laboratories, Sultan Qaboos Comprehensive Cancer Care and Research Center, Muscat 123, OmanResearch Laboratories, Sultan Qaboos Comprehensive Cancer Care and Research Center, Muscat 123, OmanResearch Laboratories, Sultan Qaboos Comprehensive Cancer Care and Research Center, Muscat 123, OmanResearch Laboratories, Sultan Qaboos Comprehensive Cancer Care and Research Center, Muscat 123, OmanMedical Oncology Department, Urogenital Cancers Program, Sultan Qaboos Comprehensive Cancer Care and Research Center, Muscat 123, OmanResearch Laboratories, Sultan Qaboos Comprehensive Cancer Care and Research Center, Muscat 123, OmanUrogenital cancers, which include prostate, bladder, and kidney malignancies, exert a substantial impact on global cancer-related morbidity and mortality. Proteomic biomarkers, emerging as valuable tools, aim to enhance early detection, prognostic accuracy, and the development of personalized therapeutic strategies. This study undertook a comprehensive systematic review and meta-analysis of the existing literature investigating the role and potential of proteomic biomarkers in plasma, tissue, and urine samples in urogenital cancers. Our extensive search across several databases identified 1879 differentially expressed proteins from 37 studies, signifying their potential as unique biomarkers for these cancers. A meta-analysis of the significantly differentially expressed proteins was executed, accentuating the findings through visually intuitive volcano plots. A functional enrichment analysis unveiled their significant involvement in diverse biological processes, including signal transduction, immune response, cell communication, and cell growth. A pathway analysis highlighted the participation of key pathways such as the nectin adhesion pathway, TRAIL signaling pathway, and integrin signaling pathways. These findings not only pave the way for future investigations into early detection and targeted therapeutic approaches but also underscore the fundamental role of proteomics in advancing our understanding of the molecular mechanisms underpinning urogenital cancer pathogenesis. Ultimately, these findings hold remarkable potential to significantly enhance patient care and improve clinical outcomes.https://www.mdpi.com/2072-6694/16/1/22prostate cancerbladder cancerkidney cancerproteomics biomarkers |
| spellingShingle | Aafaque Ahmad Khan Nahad Al-Mahrouqi Aida Al-Yahyaee Hasan Al-Sayegh Munjid Al-Harthy Shoaib Al-Zadjali Deciphering Urogenital Cancers through Proteomic Biomarkers: A Systematic Review and Meta-Analysis Cancers prostate cancer bladder cancer kidney cancer proteomics biomarkers |
| title | Deciphering Urogenital Cancers through Proteomic Biomarkers: A Systematic Review and Meta-Analysis |
| title_full | Deciphering Urogenital Cancers through Proteomic Biomarkers: A Systematic Review and Meta-Analysis |
| title_fullStr | Deciphering Urogenital Cancers through Proteomic Biomarkers: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Deciphering Urogenital Cancers through Proteomic Biomarkers: A Systematic Review and Meta-Analysis |
| title_short | Deciphering Urogenital Cancers through Proteomic Biomarkers: A Systematic Review and Meta-Analysis |
| title_sort | deciphering urogenital cancers through proteomic biomarkers a systematic review and meta analysis |
| topic | prostate cancer bladder cancer kidney cancer proteomics biomarkers |
| url | https://www.mdpi.com/2072-6694/16/1/22 |
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