Meloxicam efficacy and safety in treatment of pain syndromes of different localization according to domestic studies
More than 500 million people worldwide suffer from osteoarthritis (OA). Neck and low back pain (LBP) is one of the most common reasons for visiting a general practitioner to receive primary medical care in different countries. The prevalence of chronic LBP varies from 4% to 20%, and increases linear...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2021-12-01
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| Series: | Неврология, нейропсихиатрия, психосоматика |
| Subjects: | |
| Online Access: | https://nnp.ima-press.net/nnp/article/view/1716 |
| _version_ | 1797876262403833856 |
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| author | O. A. Shavlovskaya I. A. Bokova N. I. Shavlovskiy |
| author_facet | O. A. Shavlovskaya I. A. Bokova N. I. Shavlovskiy |
| author_sort | O. A. Shavlovskaya |
| collection | DOAJ |
| description | More than 500 million people worldwide suffer from osteoarthritis (OA). Neck and low back pain (LBP) is one of the most common reasons for visiting a general practitioner to receive primary medical care in different countries. The prevalence of chronic LBP varies from 4% to 20%, and increases linearly from the third decade to 60 years, and stabilizes in the seventh decade of life. According to the latest published clinical guidelines of the Russian Association for the Study of Pain, nonsteroidal anti-inflammatory drugs (NSAIDs) are used in minimally effective doses and a short course to relieve acute musculoskeletal pain. The ratio of the NSAIDs activity associated with cyclooxygenase (COX) – COX-1 / COX-2 – inhibition allows us to evaluate their potential toxicity. The smaller this value, the more selective the drug is against COX-2, and the less toxic it is. Meloxicam belongs to the predominantly selective COX-2 inhibitors. In the Russian market, meloxicam of domestic production - Amelotex® is widely prescribed. Several studies have shown the high efficacy and safety of meloxicam in the treatment of pain syndromes with different localizations (LBP, neck pain of vertebrogenic nature, OA, etc.), it can be recommended for elderly patients, patients with comorbid diseases such as arterial hypertension (AH), diabetes mellitus, gastrointestinal tract pathology. Meloxicam has a good efficacy and safety profile, a pronounced symptom-modifying effect. |
| first_indexed | 2024-04-10T02:00:29Z |
| format | Article |
| id | doaj.art-0f62e73b33ab405db97b8f070194520d |
| institution | Directory Open Access Journal |
| issn | 2074-2711 2310-1342 |
| language | Russian |
| last_indexed | 2024-04-10T02:00:29Z |
| publishDate | 2021-12-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Неврология, нейропсихиатрия, психосоматика |
| spelling | doaj.art-0f62e73b33ab405db97b8f070194520d2023-03-13T08:42:22ZrusIMA-PRESS LLCНеврология, нейропсихиатрия, психосоматика2074-27112310-13422021-12-0113611712310.14412/2074-2711-2021-6-117-1231220Meloxicam efficacy and safety in treatment of pain syndromes of different localization according to domestic studiesO. A. Shavlovskaya0I. A. Bokova1N. I. Shavlovskiy2International University of Restorative MedicineI.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaI.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaMore than 500 million people worldwide suffer from osteoarthritis (OA). Neck and low back pain (LBP) is one of the most common reasons for visiting a general practitioner to receive primary medical care in different countries. The prevalence of chronic LBP varies from 4% to 20%, and increases linearly from the third decade to 60 years, and stabilizes in the seventh decade of life. According to the latest published clinical guidelines of the Russian Association for the Study of Pain, nonsteroidal anti-inflammatory drugs (NSAIDs) are used in minimally effective doses and a short course to relieve acute musculoskeletal pain. The ratio of the NSAIDs activity associated with cyclooxygenase (COX) – COX-1 / COX-2 – inhibition allows us to evaluate their potential toxicity. The smaller this value, the more selective the drug is against COX-2, and the less toxic it is. Meloxicam belongs to the predominantly selective COX-2 inhibitors. In the Russian market, meloxicam of domestic production - Amelotex® is widely prescribed. Several studies have shown the high efficacy and safety of meloxicam in the treatment of pain syndromes with different localizations (LBP, neck pain of vertebrogenic nature, OA, etc.), it can be recommended for elderly patients, patients with comorbid diseases such as arterial hypertension (AH), diabetes mellitus, gastrointestinal tract pathology. Meloxicam has a good efficacy and safety profile, a pronounced symptom-modifying effect.https://nnp.ima-press.net/nnp/article/view/1716pain syndromelow back painosteoarthritisnonsteroidal anti-inflammatory drugsmeloxicamamelotex® |
| spellingShingle | O. A. Shavlovskaya I. A. Bokova N. I. Shavlovskiy Meloxicam efficacy and safety in treatment of pain syndromes of different localization according to domestic studies Неврология, нейропсихиатрия, психосоматика pain syndrome low back pain osteoarthritis nonsteroidal anti-inflammatory drugs meloxicam amelotex® |
| title | Meloxicam efficacy and safety in treatment of pain syndromes of different localization according to domestic studies |
| title_full | Meloxicam efficacy and safety in treatment of pain syndromes of different localization according to domestic studies |
| title_fullStr | Meloxicam efficacy and safety in treatment of pain syndromes of different localization according to domestic studies |
| title_full_unstemmed | Meloxicam efficacy and safety in treatment of pain syndromes of different localization according to domestic studies |
| title_short | Meloxicam efficacy and safety in treatment of pain syndromes of different localization according to domestic studies |
| title_sort | meloxicam efficacy and safety in treatment of pain syndromes of different localization according to domestic studies |
| topic | pain syndrome low back pain osteoarthritis nonsteroidal anti-inflammatory drugs meloxicam amelotex® |
| url | https://nnp.ima-press.net/nnp/article/view/1716 |
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