Peptidylarginine deiminase 2 citrullinates MZB1 and promotes the secretion of IgM and IgA

IntroductionMZB1 is an endoplasmic reticulum residential protein preferentially expressed in plasma cells, marginal zone and B1 B cells. Recent studies on murine B cells show that it interacts with the tail piece of IgM and IgA heavy chain and promotes the secretion of these two classes of immunoglo...

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Bibliographic Details
Main Authors: Benjamin Geary, Bo Sun, Ronak R. Tilvawala, Leonard Barasa, Konstantin Tsoyi, Ivan O. Rosas, Paul R. Thompson, I-Cheng Ho
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1290585/full