Testostérone and Positive Dimension in Schizophrenia
Introduction Schizophrenia is characterised by a loss of contact with reality due to the presence in its symptomatology of a delusional and/or hallucinatory syndrome, also called positive symptoms and/or a dissociative syndrome, which reflects the negative component of the disease. Few studies sugg...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2023-03-01
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| Series: | European Psychiatry |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933823022502/type/journal_article |
| _version_ | 1797616902320685056 |
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| author | I. Bouguerra E. Khelifa A. Adouni Y. Sellaouti H. Ben Ammar L. Mnif |
| author_facet | I. Bouguerra E. Khelifa A. Adouni Y. Sellaouti H. Ben Ammar L. Mnif |
| author_sort | I. Bouguerra |
| collection | DOAJ |
| description |
Introduction
Schizophrenia is characterised by a loss of contact with reality due to the presence in its symptomatology of a delusional and/or hallucinatory syndrome, also called positive symptoms and/or a dissociative syndrome, which reflects the negative component of the disease. Few studies suggest a probable link between testosterone and the symptomatic dimension of schizophrenia, but this subject remains poorly documented.
Objectives
The purpose of this study was to describe Testosterone profile in male patients with schizophrenia who are naïve to antipsychotic treatment or have been off it for at least two months and to investigate the relationship between testosterone levels and disease severity.
Methods
This was a descriptive, cross-sectional study of fifty male patients hospitalized for a psychotic relapse who were naïve or discontinuing treatment for at least two months. Patients were assessed using a semi-structured questionnaire and The Positive and Negative Syndrome Scale (PANSS). A blood sample was taken to measure testosterone level.
Results
The age of the patients included ranged from 17 to 65 years, with an average of 36.4±11.51 years. The PANSS score ranged from 50 to 195 with a mean of 116.76 +/- 31.817. Testosterone values ranged from 2.01 to 10.03 ng/ml with a mean of 4.74± 2.01 ng/ml. The majority had normal testosterone levels (94%) ; only 4% had high values and 2% had low values. A positive correlation was found between the positive component of PANSS and elevated testosterone (p=0.011). For the other subscales, no correlation with testosterone levels.
Conclusions
The present study is in favour of a testosterone aggravation of the mostly positive clinical signs of the disease in a significant way. Hormone assays could thus be a specific marker of certain patient profile with a particular evolution.
Disclosure of Interest
None Declared |
| first_indexed | 2024-03-11T07:47:54Z |
| format | Article |
| id | doaj.art-0f6416cf3eeb4f5cada21682c776f6cf |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:47:54Z |
| publishDate | 2023-03-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-0f6416cf3eeb4f5cada21682c776f6cf2023-11-17T05:07:13ZengCambridge University PressEuropean Psychiatry0924-93381778-35852023-03-0166S1060S106010.1192/j.eurpsy.2023.2250Testostérone and Positive Dimension in SchizophreniaI. Bouguerra0E. Khelifa1A. Adouni2Y. Sellaouti3H. Ben Ammar4L. Mnif5F pyshciatry departement, Razi Hospital, Mannouba, TunisiaF pyshciatry departement, Razi Hospital, Mannouba, TunisiaF pyshciatry departement, Razi Hospital, Mannouba, TunisiaF pyshciatry departement, Razi Hospital, Mannouba, TunisiaF pyshciatry departement, Razi Hospital, Mannouba, TunisiaF pyshciatry departement, Razi Hospital, Mannouba, Tunisia Introduction Schizophrenia is characterised by a loss of contact with reality due to the presence in its symptomatology of a delusional and/or hallucinatory syndrome, also called positive symptoms and/or a dissociative syndrome, which reflects the negative component of the disease. Few studies suggest a probable link between testosterone and the symptomatic dimension of schizophrenia, but this subject remains poorly documented. Objectives The purpose of this study was to describe Testosterone profile in male patients with schizophrenia who are naïve to antipsychotic treatment or have been off it for at least two months and to investigate the relationship between testosterone levels and disease severity. Methods This was a descriptive, cross-sectional study of fifty male patients hospitalized for a psychotic relapse who were naïve or discontinuing treatment for at least two months. Patients were assessed using a semi-structured questionnaire and The Positive and Negative Syndrome Scale (PANSS). A blood sample was taken to measure testosterone level. Results The age of the patients included ranged from 17 to 65 years, with an average of 36.4±11.51 years. The PANSS score ranged from 50 to 195 with a mean of 116.76 +/- 31.817. Testosterone values ranged from 2.01 to 10.03 ng/ml with a mean of 4.74± 2.01 ng/ml. The majority had normal testosterone levels (94%) ; only 4% had high values and 2% had low values. A positive correlation was found between the positive component of PANSS and elevated testosterone (p=0.011). For the other subscales, no correlation with testosterone levels. Conclusions The present study is in favour of a testosterone aggravation of the mostly positive clinical signs of the disease in a significant way. Hormone assays could thus be a specific marker of certain patient profile with a particular evolution. Disclosure of Interest None Declaredhttps://www.cambridge.org/core/product/identifier/S0924933823022502/type/journal_article |
| spellingShingle | I. Bouguerra E. Khelifa A. Adouni Y. Sellaouti H. Ben Ammar L. Mnif Testostérone and Positive Dimension in Schizophrenia European Psychiatry |
| title | Testostérone and Positive Dimension in Schizophrenia |
| title_full | Testostérone and Positive Dimension in Schizophrenia |
| title_fullStr | Testostérone and Positive Dimension in Schizophrenia |
| title_full_unstemmed | Testostérone and Positive Dimension in Schizophrenia |
| title_short | Testostérone and Positive Dimension in Schizophrenia |
| title_sort | testosterone and positive dimension in schizophrenia |
| url | https://www.cambridge.org/core/product/identifier/S0924933823022502/type/journal_article |
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