Liver cirrhosis as a result of chronic hepatitis C
The incidence of chronic hepatitis C in St. Petersburg is 124.4 per 100 000 population. The number of patients with liver cirrhosis is significant.Aim of this study: to examine the demographic, clinical and epidemiological characteristics of patients with cirrhosis in the results of chronic hepatiti...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2014-09-01
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| Series: | Журнал инфектологии |
| Subjects: | |
| Online Access: | https://journal.niidi.ru/jofin/article/view/223 |
| _version_ | 1797702609205723136 |
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| author | A. A. Sukhoruk O. A. Gerasimova E. V. Esaulenko |
| author_facet | A. A. Sukhoruk O. A. Gerasimova E. V. Esaulenko |
| author_sort | A. A. Sukhoruk |
| collection | DOAJ |
| description | The incidence of chronic hepatitis C in St. Petersburg is 124.4 per 100 000 population. The number of patients with liver cirrhosis is significant.Aim of this study: to examine the demographic, clinical and epidemiological characteristics of patients with cirrhosis in the results of chronic hepatitis C.Materials and methods: 100 patients with cirrhosis due to chronic hepatitis C in age 31–70 years were included. Patients with infection hepatitis viruses A and B, HIV, alcohol abuse, drug addicts, previously received antiviral therapy were excluded. Liver cirrhosis was diagnosed on the basis clinical, laboratory and instrumental investigations.Results: most patients (86,2% male and 81,7% female) are socially adapted. In 23,2% of patients antibodies to hepatitis C virus were first detected simultaneously with the diagnosis of cirrhosis. Medical procedures were the most common route of infection (25,6% male and 57,1% female). Genotype 1 was dominant (65.7%). Viral load over 800 000 IU/ml was detected in 36,7% of patients. ALT activity was normal or not more than 2 upper limit of normal in 59% of patients, AST – 47%. Normal levels of total bilirubin were recorded in 37% of cases.Conclusions: the first detection of antibodies to hepatitis C virus at the stage of cirrhosis, absence of jaundice, normal or low cytolytic activity once again confirms the need for screening for markers of hepatitis C virus. Dominance of genotype 1 is probably due on the one hand with features routes of transmission, and the other – with the speed of transformation chronic hepatitis to cirrhosis. |
| first_indexed | 2024-03-12T04:52:31Z |
| format | Article |
| id | doaj.art-0f655c657569403b86f87e57032ff9f2 |
| institution | Directory Open Access Journal |
| issn | 2072-6732 |
| language | Russian |
| last_indexed | 2024-03-12T04:52:31Z |
| publishDate | 2014-09-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj.art-0f655c657569403b86f87e57032ff9f22023-09-03T09:18:12ZrusJournal InfectologyЖурнал инфектологии2072-67322014-09-0161677110.22625/2072-6732-2014-6-1-67-71237Liver cirrhosis as a result of chronic hepatitis CA. A. Sukhoruk0O. A. Gerasimova1E. V. Esaulenko2Санкт-Петербургский государственный педиатрический медицинский университет, Санкт-Петербург, РоссияРоссийский научный центр радиологии и хирургических технологий, Санкт-Петербург, РоссияСанкт-Петербургский государственный педиатрический медицинский университет, Санкт-Петербург, РоссияThe incidence of chronic hepatitis C in St. Petersburg is 124.4 per 100 000 population. The number of patients with liver cirrhosis is significant.Aim of this study: to examine the demographic, clinical and epidemiological characteristics of patients with cirrhosis in the results of chronic hepatitis C.Materials and methods: 100 patients with cirrhosis due to chronic hepatitis C in age 31–70 years were included. Patients with infection hepatitis viruses A and B, HIV, alcohol abuse, drug addicts, previously received antiviral therapy were excluded. Liver cirrhosis was diagnosed on the basis clinical, laboratory and instrumental investigations.Results: most patients (86,2% male and 81,7% female) are socially adapted. In 23,2% of patients antibodies to hepatitis C virus were first detected simultaneously with the diagnosis of cirrhosis. Medical procedures were the most common route of infection (25,6% male and 57,1% female). Genotype 1 was dominant (65.7%). Viral load over 800 000 IU/ml was detected in 36,7% of patients. ALT activity was normal or not more than 2 upper limit of normal in 59% of patients, AST – 47%. Normal levels of total bilirubin were recorded in 37% of cases.Conclusions: the first detection of antibodies to hepatitis C virus at the stage of cirrhosis, absence of jaundice, normal or low cytolytic activity once again confirms the need for screening for markers of hepatitis C virus. Dominance of genotype 1 is probably due on the one hand with features routes of transmission, and the other – with the speed of transformation chronic hepatitis to cirrhosis.https://journal.niidi.ru/jofin/article/view/223гепатит сцирроз печенигенотипы вируса гепатита с |
| spellingShingle | A. A. Sukhoruk O. A. Gerasimova E. V. Esaulenko Liver cirrhosis as a result of chronic hepatitis C Журнал инфектологии гепатит с цирроз печени генотипы вируса гепатита с |
| title | Liver cirrhosis as a result of chronic hepatitis C |
| title_full | Liver cirrhosis as a result of chronic hepatitis C |
| title_fullStr | Liver cirrhosis as a result of chronic hepatitis C |
| title_full_unstemmed | Liver cirrhosis as a result of chronic hepatitis C |
| title_short | Liver cirrhosis as a result of chronic hepatitis C |
| title_sort | liver cirrhosis as a result of chronic hepatitis c |
| topic | гепатит с цирроз печени генотипы вируса гепатита с |
| url | https://journal.niidi.ru/jofin/article/view/223 |
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