CCL2: An important cytokine in normal and pathological pregnancies: A review
C-C motif ligand 2 (CCL2), also known as monocytic chemotactic protein 1 (MCP-1), is an integral chemotactic factor which recruits macrophages for the immune response. Together with its receptors (e.g., CCR2, ACKR1, and ACKR2), they exert noticeable influences on various diseases of different system...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1053457/full |
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| author | Zhi Lin Zhi Lin Jia-Lu Shi Min Chen Zi-Meng Zheng Ming-Qing Li Ming-Qing Li Ming-Qing Li Ming-Qing Li Jun Shao Jun Shao |
| author_facet | Zhi Lin Zhi Lin Jia-Lu Shi Min Chen Zi-Meng Zheng Ming-Qing Li Ming-Qing Li Ming-Qing Li Ming-Qing Li Jun Shao Jun Shao |
| author_sort | Zhi Lin |
| collection | DOAJ |
| description | C-C motif ligand 2 (CCL2), also known as monocytic chemotactic protein 1 (MCP-1), is an integral chemotactic factor which recruits macrophages for the immune response. Together with its receptors (e.g., CCR2, ACKR1, and ACKR2), they exert noticeable influences on various diseases of different systems. At the maternal-fetal interface, CCL2 is detected to be expressed in trophoblasts, decidual tissue, the myometrium, and others. Meanwhile, existing reports have determined a series of physiological regulators of CCL2, which functions in maintaining normal recruitment of immunocytes, tissue remodeling, and angiogenesis. However, abnormal levels of CCL2 have also been reported to be associated with adverse pregnancy outcomes such as spontaneous abortion, preeclampsia and preterm labor. In this review, we concentrate on CCL2 expression at the maternal-fetal interface, as well as its precise regulatory mechanisms and classic signaling pathways, to reveal the multidimensional aspects of CCL2 in pregnancy. |
| first_indexed | 2024-04-11T00:37:42Z |
| format | Article |
| id | doaj.art-0f65ac0bce3f4686a9f9bfe4712cd505 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T00:37:42Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-0f65ac0bce3f4686a9f9bfe4712cd5052023-01-06T14:13:35ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-01-011310.3389/fimmu.2022.10534571053457CCL2: An important cytokine in normal and pathological pregnancies: A reviewZhi Lin0Zhi Lin1Jia-Lu Shi2Min Chen3Zi-Meng Zheng4Ming-Qing Li5Ming-Qing Li6Ming-Qing Li7Ming-Qing Li8Jun Shao9Jun Shao10Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, ChinaDepartment of Gynecology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, ChinaLaboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, ChinaLaboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, ChinaLaboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, ChinaLaboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, ChinaNational Health Commision (NHC) Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University, Shanghai, ChinaShanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, ChinaDepartment of Obstetrics and Gynecology, Jinshan Hospital of Fudan University, Shanghai, ChinaDepartment of Gynecology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, ChinaShanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, ChinaC-C motif ligand 2 (CCL2), also known as monocytic chemotactic protein 1 (MCP-1), is an integral chemotactic factor which recruits macrophages for the immune response. Together with its receptors (e.g., CCR2, ACKR1, and ACKR2), they exert noticeable influences on various diseases of different systems. At the maternal-fetal interface, CCL2 is detected to be expressed in trophoblasts, decidual tissue, the myometrium, and others. Meanwhile, existing reports have determined a series of physiological regulators of CCL2, which functions in maintaining normal recruitment of immunocytes, tissue remodeling, and angiogenesis. However, abnormal levels of CCL2 have also been reported to be associated with adverse pregnancy outcomes such as spontaneous abortion, preeclampsia and preterm labor. In this review, we concentrate on CCL2 expression at the maternal-fetal interface, as well as its precise regulatory mechanisms and classic signaling pathways, to reveal the multidimensional aspects of CCL2 in pregnancy.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1053457/fullCCL2CCR2trophoblastdeciduaabortionpreeclampsia |
| spellingShingle | Zhi Lin Zhi Lin Jia-Lu Shi Min Chen Zi-Meng Zheng Ming-Qing Li Ming-Qing Li Ming-Qing Li Ming-Qing Li Jun Shao Jun Shao CCL2: An important cytokine in normal and pathological pregnancies: A review Frontiers in Immunology CCL2 CCR2 trophoblast decidua abortion preeclampsia |
| title | CCL2: An important cytokine in normal and pathological pregnancies: A review |
| title_full | CCL2: An important cytokine in normal and pathological pregnancies: A review |
| title_fullStr | CCL2: An important cytokine in normal and pathological pregnancies: A review |
| title_full_unstemmed | CCL2: An important cytokine in normal and pathological pregnancies: A review |
| title_short | CCL2: An important cytokine in normal and pathological pregnancies: A review |
| title_sort | ccl2 an important cytokine in normal and pathological pregnancies a review |
| topic | CCL2 CCR2 trophoblast decidua abortion preeclampsia |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1053457/full |
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