Probing Critical Physical Properties of Lactose-Polyethylene Glycol Microparticles in Pulmonary Delivery of Chitosan Nanoparticles
Pulmonary delivery of chitosan nanoparticles is met with nanoparticle agglomeration and exhalation. Admixing lactose-based microparticles (surface area-weighted diameter~5 μm) with nanoparticles mutually reduces particle agglomeration through surface adsorption phenomenon. Lactose-polyethylene glyco...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/13/10/1581 |
| _version_ | 1827678790517522432 |
|---|---|
| author | Nasser Alhajj Idanawati Naharudin Paolo Colombo Eride Quarta Tin Wui Wong |
| author_facet | Nasser Alhajj Idanawati Naharudin Paolo Colombo Eride Quarta Tin Wui Wong |
| author_sort | Nasser Alhajj |
| collection | DOAJ |
| description | Pulmonary delivery of chitosan nanoparticles is met with nanoparticle agglomeration and exhalation. Admixing lactose-based microparticles (surface area-weighted diameter~5 μm) with nanoparticles mutually reduces particle agglomeration through surface adsorption phenomenon. Lactose-polyethylene glycol (PEG) microparticles with different sizes, morphologies and crystallinities were prepared by a spray drying method using varying PEG molecular weights and ethanol contents. The chitosan nanoparticles were similarly prepared. In vitro inhalation performance and peripheral lung deposition of chitosan nanoparticles were enhanced through co-blending with larger lactose-PEG microparticles with reduced specific surface area. These microparticles had reduced inter-microparticle interaction, thereby promoting microparticle–nanoparticle interaction and facilitating nanoparticles flow into peripheral lung. |
| first_indexed | 2024-03-10T06:15:54Z |
| format | Article |
| id | doaj.art-0f67638066f44c7196c58cdfaae5820d |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T06:15:54Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-0f67638066f44c7196c58cdfaae5820d2023-11-22T19:37:58ZengMDPI AGPharmaceutics1999-49232021-09-011310158110.3390/pharmaceutics13101581Probing Critical Physical Properties of Lactose-Polyethylene Glycol Microparticles in Pulmonary Delivery of Chitosan NanoparticlesNasser Alhajj0Idanawati Naharudin1Paolo Colombo2Eride Quarta3Tin Wui Wong4Non-Destructive Biomedical and Pharmaceutical Research Centre, Smart Manufacturing Research Institute, Universiti Teknologi MARA Selangor, Puncak Alam 42300, Selangor, MalaysiaNon-Destructive Biomedical and Pharmaceutical Research Centre, Smart Manufacturing Research Institute, Universiti Teknologi MARA Selangor, Puncak Alam 42300, Selangor, MalaysiaPlumeStars srl, 43125 Parma, ItalyFood and Drug Department, University of Parma, 43121 Parma, ItalyNon-Destructive Biomedical and Pharmaceutical Research Centre, Smart Manufacturing Research Institute, Universiti Teknologi MARA Selangor, Puncak Alam 42300, Selangor, MalaysiaPulmonary delivery of chitosan nanoparticles is met with nanoparticle agglomeration and exhalation. Admixing lactose-based microparticles (surface area-weighted diameter~5 μm) with nanoparticles mutually reduces particle agglomeration through surface adsorption phenomenon. Lactose-polyethylene glycol (PEG) microparticles with different sizes, morphologies and crystallinities were prepared by a spray drying method using varying PEG molecular weights and ethanol contents. The chitosan nanoparticles were similarly prepared. In vitro inhalation performance and peripheral lung deposition of chitosan nanoparticles were enhanced through co-blending with larger lactose-PEG microparticles with reduced specific surface area. These microparticles had reduced inter-microparticle interaction, thereby promoting microparticle–nanoparticle interaction and facilitating nanoparticles flow into peripheral lung.https://www.mdpi.com/1999-4923/13/10/1581chitosanlactosemicroparticlenanoparticlepulmonary delivery |
| spellingShingle | Nasser Alhajj Idanawati Naharudin Paolo Colombo Eride Quarta Tin Wui Wong Probing Critical Physical Properties of Lactose-Polyethylene Glycol Microparticles in Pulmonary Delivery of Chitosan Nanoparticles Pharmaceutics chitosan lactose microparticle nanoparticle pulmonary delivery |
| title | Probing Critical Physical Properties of Lactose-Polyethylene Glycol Microparticles in Pulmonary Delivery of Chitosan Nanoparticles |
| title_full | Probing Critical Physical Properties of Lactose-Polyethylene Glycol Microparticles in Pulmonary Delivery of Chitosan Nanoparticles |
| title_fullStr | Probing Critical Physical Properties of Lactose-Polyethylene Glycol Microparticles in Pulmonary Delivery of Chitosan Nanoparticles |
| title_full_unstemmed | Probing Critical Physical Properties of Lactose-Polyethylene Glycol Microparticles in Pulmonary Delivery of Chitosan Nanoparticles |
| title_short | Probing Critical Physical Properties of Lactose-Polyethylene Glycol Microparticles in Pulmonary Delivery of Chitosan Nanoparticles |
| title_sort | probing critical physical properties of lactose polyethylene glycol microparticles in pulmonary delivery of chitosan nanoparticles |
| topic | chitosan lactose microparticle nanoparticle pulmonary delivery |
| url | https://www.mdpi.com/1999-4923/13/10/1581 |
| work_keys_str_mv | AT nasseralhajj probingcriticalphysicalpropertiesoflactosepolyethyleneglycolmicroparticlesinpulmonarydeliveryofchitosannanoparticles AT idanawatinaharudin probingcriticalphysicalpropertiesoflactosepolyethyleneglycolmicroparticlesinpulmonarydeliveryofchitosannanoparticles AT paolocolombo probingcriticalphysicalpropertiesoflactosepolyethyleneglycolmicroparticlesinpulmonarydeliveryofchitosannanoparticles AT eridequarta probingcriticalphysicalpropertiesoflactosepolyethyleneglycolmicroparticlesinpulmonarydeliveryofchitosannanoparticles AT tinwuiwong probingcriticalphysicalpropertiesoflactosepolyethyleneglycolmicroparticlesinpulmonarydeliveryofchitosannanoparticles |