Use of Cell and Genome Modification Technologies to Generate Improved “Off-the-Shelf” CAR T and CAR NK Cells

Use of Cell and Genome Modification Technologies to Generate Improved “Off-the-Shelf” CAR T and CAR NK Cells

The broad success of adoptive immunotherapy to treat human cancer has resulted in a paradigm shift in modern medicine. Modification of autologous and allogenic immune cells with chimeric antigen receptors (CAR) designed to target specific antigens on tumor cells has led to production of CAR T and CA...

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Bibliographic Details
Main Authors: Michael A. Morgan, Hildegard Büning, Martin Sauer, Axel Schambach
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
chimeric antigen receptor
T cell
immunotherapy
genome editing
CRISPR-Cas9
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01965/full

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