MicroRNA Let-7 targets AMPK and impairs hepatic lipid metabolism in offspring of maternal obese pregnancies

MicroRNA Let-7 targets AMPK and impairs hepatic lipid metabolism in offspring of maternal obese pregnancies

Abstract Nutritional status during gestation may lead to a phenomenon known as metabolic programming, which can be triggered by epigenetic mechanisms. The Let-7 family of microRNAs were one of the first to be discovered, and are closely related to metabolic processes. Bioinformatic analysis revealed...

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Bibliographic Details
Main Authors: Laís A. P. Simino, Carolina Panzarin, Marina F. Fontana, Thais de Fante, Murilo V. Geraldo, Letícia M. Ignácio-Souza, Marciane Milanski, Marcio A. Torsoni, Michael G. Ross, Mina Desai, Adriana S. Torsoni
Format: Article
Language:English
Published: Nature Portfolio 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-88518-8

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