Serum apolipoprotein A-IV levels are associated with flow-mediated dilation in patients with type 2 diabetes mellitus
Abstract Background Endothelial dysfunction is common in diabetes. Apolipoprotein (apo) A-IV functions to antagonize inflammation and oxidative stress. The present study aimed to investigate the relationship between flow-mediated dilation (FMD) and serum apoA-IV level in type 2 diabetes mellitus (T2...
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-022-02898-x |
| _version_ | 1811335412709326848 |
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| author | Le-Ying Li Shuai Chen Yi-Xuan Wang Ri Ji Feng-Hua Ding Xiao-Qun Wang Qiu-Jing Chen Lin Lu Yang Dai |
| author_facet | Le-Ying Li Shuai Chen Yi-Xuan Wang Ri Ji Feng-Hua Ding Xiao-Qun Wang Qiu-Jing Chen Lin Lu Yang Dai |
| author_sort | Le-Ying Li |
| collection | DOAJ |
| description | Abstract Background Endothelial dysfunction is common in diabetes. Apolipoprotein (apo) A-IV functions to antagonize inflammation and oxidative stress. The present study aimed to investigate the relationship between flow-mediated dilation (FMD) and serum apoA-IV level in type 2 diabetes mellitus (T2DM) patients. Methods A total of 84 T2DM patients with chest discomfort were enrolled in this study. Their baseline characteristics and clinical parameters were documented. Endothelial function of the participants was evaluated by examining FMD of brachial artery. The severity of coronary atherosclerosis was determined by quantitative coronary angiography. Serum apoA-IV levels were measured by ELISA. Results These diabetic patients were dichotomized into low FMD (n = 42) and high FMD (n = 42) groups. Serum apoA-IV levels were significantly higher in high FMD group than in low FMD group (29.96 ± 13.17 vs 17.69 ± 9.16 mg/dL, P < 0.001). Moreover, the patients were also categorized into three apoA-IV tertile groups. FMD was significantly different across three apoA-IV tertiles (P < 0.001). Serum apoA-IV levels were positively correlated to FMD (r = 0.469, P < 0.001). Logistic regression analysis was performed to determine risk factors for low FMD. apoA-IV levels together with the risk factor hsCRP remained significantly to be independent determinants of low FMD (P < 0.01). Linear regression analysis was performed, and apoA-IV levels together with total-to-HDL cholesterol ratio were independently correlated with FMD (P < 0.01). Conclusions Serum apoA-IV levels are associated with FMD, suggesting that apoA-IV protects endothelial function in patients with T2DM. |
| first_indexed | 2024-04-13T17:23:48Z |
| format | Article |
| id | doaj.art-0f68df3e0c1d49cdaedf81a8a3a00449 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-13T17:23:48Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-0f68df3e0c1d49cdaedf81a8a3a004492022-12-22T02:37:52ZengBMCBMC Cardiovascular Disorders1471-22612022-10-012211810.1186/s12872-022-02898-xSerum apolipoprotein A-IV levels are associated with flow-mediated dilation in patients with type 2 diabetes mellitusLe-Ying Li0Shuai Chen1Yi-Xuan Wang2Ri Ji3Feng-Hua Ding4Xiao-Qun Wang5Qiu-Jing Chen6Lin Lu7Yang Dai8Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineInstitute of Cardiovascular Diseases, Shanghai Jiao Tong University School of MedicineDepartment of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineAbstract Background Endothelial dysfunction is common in diabetes. Apolipoprotein (apo) A-IV functions to antagonize inflammation and oxidative stress. The present study aimed to investigate the relationship between flow-mediated dilation (FMD) and serum apoA-IV level in type 2 diabetes mellitus (T2DM) patients. Methods A total of 84 T2DM patients with chest discomfort were enrolled in this study. Their baseline characteristics and clinical parameters were documented. Endothelial function of the participants was evaluated by examining FMD of brachial artery. The severity of coronary atherosclerosis was determined by quantitative coronary angiography. Serum apoA-IV levels were measured by ELISA. Results These diabetic patients were dichotomized into low FMD (n = 42) and high FMD (n = 42) groups. Serum apoA-IV levels were significantly higher in high FMD group than in low FMD group (29.96 ± 13.17 vs 17.69 ± 9.16 mg/dL, P < 0.001). Moreover, the patients were also categorized into three apoA-IV tertile groups. FMD was significantly different across three apoA-IV tertiles (P < 0.001). Serum apoA-IV levels were positively correlated to FMD (r = 0.469, P < 0.001). Logistic regression analysis was performed to determine risk factors for low FMD. apoA-IV levels together with the risk factor hsCRP remained significantly to be independent determinants of low FMD (P < 0.01). Linear regression analysis was performed, and apoA-IV levels together with total-to-HDL cholesterol ratio were independently correlated with FMD (P < 0.01). Conclusions Serum apoA-IV levels are associated with FMD, suggesting that apoA-IV protects endothelial function in patients with T2DM.https://doi.org/10.1186/s12872-022-02898-xFlow-mediated dilationEndothelial functionApolipoprotein A-IVType 2 diabetes mellitus |
| spellingShingle | Le-Ying Li Shuai Chen Yi-Xuan Wang Ri Ji Feng-Hua Ding Xiao-Qun Wang Qiu-Jing Chen Lin Lu Yang Dai Serum apolipoprotein A-IV levels are associated with flow-mediated dilation in patients with type 2 diabetes mellitus BMC Cardiovascular Disorders Flow-mediated dilation Endothelial function Apolipoprotein A-IV Type 2 diabetes mellitus |
| title | Serum apolipoprotein A-IV levels are associated with flow-mediated dilation in patients with type 2 diabetes mellitus |
| title_full | Serum apolipoprotein A-IV levels are associated with flow-mediated dilation in patients with type 2 diabetes mellitus |
| title_fullStr | Serum apolipoprotein A-IV levels are associated with flow-mediated dilation in patients with type 2 diabetes mellitus |
| title_full_unstemmed | Serum apolipoprotein A-IV levels are associated with flow-mediated dilation in patients with type 2 diabetes mellitus |
| title_short | Serum apolipoprotein A-IV levels are associated with flow-mediated dilation in patients with type 2 diabetes mellitus |
| title_sort | serum apolipoprotein a iv levels are associated with flow mediated dilation in patients with type 2 diabetes mellitus |
| topic | Flow-mediated dilation Endothelial function Apolipoprotein A-IV Type 2 diabetes mellitus |
| url | https://doi.org/10.1186/s12872-022-02898-x |
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