Mesenchymal Stromal Cell-Based Bone Regeneration Therapies: From Cell Transplantation and Tissue Engineering to Therapeutic Secretomes and Extracellular Vesicles
Effective regeneration of bone defects often presents significant challenges, particularly in patients with decreased tissue regeneration capacity due to extensive trauma, disease, and/or advanced age. A number of studies have focused on enhancing bone regeneration by applying mesenchymal stromal ce...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fbioe.2019.00352/full |
| _version_ | 1819177024097353728 |
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| author | Darja Marolt Presen Darja Marolt Presen Andreas Traweger Andreas Traweger Mario Gimona Heinz Redl Heinz Redl |
| author_facet | Darja Marolt Presen Darja Marolt Presen Andreas Traweger Andreas Traweger Mario Gimona Heinz Redl Heinz Redl |
| author_sort | Darja Marolt Presen |
| collection | DOAJ |
| description | Effective regeneration of bone defects often presents significant challenges, particularly in patients with decreased tissue regeneration capacity due to extensive trauma, disease, and/or advanced age. A number of studies have focused on enhancing bone regeneration by applying mesenchymal stromal cells (MSCs) or MSC-based bone tissue engineering strategies. However, translation of these approaches from basic research findings to clinical use has been hampered by the limited understanding of MSC therapeutic actions and complexities, as well as costs related to the manufacturing, regulatory approval, and clinical use of living cells and engineered tissues. More recently, a shift from the view of MSCs directly contributing to tissue regeneration toward appreciating MSCs as “cell factories” that secrete a variety of bioactive molecules and extracellular vesicles with trophic and immunomodulatory activities has steered research into new MSC-based, “cell-free” therapeutic modalities. The current review recapitulates recent developments, challenges, and future perspectives of these various MSC-based bone tissue engineering and regeneration strategies. |
| first_indexed | 2024-12-22T21:20:04Z |
| format | Article |
| id | doaj.art-0f694a6e5a0a4dde8ad5f253f5e82b2f |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-22T21:20:04Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-0f694a6e5a0a4dde8ad5f253f5e82b2f2022-12-21T18:12:14ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852019-11-01710.3389/fbioe.2019.00352496423Mesenchymal Stromal Cell-Based Bone Regeneration Therapies: From Cell Transplantation and Tissue Engineering to Therapeutic Secretomes and Extracellular VesiclesDarja Marolt Presen0Darja Marolt Presen1Andreas Traweger2Andreas Traweger3Mario Gimona4Heinz Redl5Heinz Redl6Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Vienna, AustriaAustrian Cluster for Tissue Regeneration, Vienna, AustriaAustrian Cluster for Tissue Regeneration, Vienna, AustriaSpinal Cord Injury & Tissue Regeneration Center Salzburg, Institute of Tendon and Bone Regeneration, Paracelsus Medical University, Salzburg, AustriaGMP Unit, Spinal Cord Injury & Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, AustriaLudwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Vienna, AustriaAustrian Cluster for Tissue Regeneration, Vienna, AustriaEffective regeneration of bone defects often presents significant challenges, particularly in patients with decreased tissue regeneration capacity due to extensive trauma, disease, and/or advanced age. A number of studies have focused on enhancing bone regeneration by applying mesenchymal stromal cells (MSCs) or MSC-based bone tissue engineering strategies. However, translation of these approaches from basic research findings to clinical use has been hampered by the limited understanding of MSC therapeutic actions and complexities, as well as costs related to the manufacturing, regulatory approval, and clinical use of living cells and engineered tissues. More recently, a shift from the view of MSCs directly contributing to tissue regeneration toward appreciating MSCs as “cell factories” that secrete a variety of bioactive molecules and extracellular vesicles with trophic and immunomodulatory activities has steered research into new MSC-based, “cell-free” therapeutic modalities. The current review recapitulates recent developments, challenges, and future perspectives of these various MSC-based bone tissue engineering and regeneration strategies.https://www.frontiersin.org/article/10.3389/fbioe.2019.00352/fullmesenchymal stromal cellsstem cellsMSCssecretomeextracellular vesiclescell therapy |
| spellingShingle | Darja Marolt Presen Darja Marolt Presen Andreas Traweger Andreas Traweger Mario Gimona Heinz Redl Heinz Redl Mesenchymal Stromal Cell-Based Bone Regeneration Therapies: From Cell Transplantation and Tissue Engineering to Therapeutic Secretomes and Extracellular Vesicles Frontiers in Bioengineering and Biotechnology mesenchymal stromal cells stem cells MSCs secretome extracellular vesicles cell therapy |
| title | Mesenchymal Stromal Cell-Based Bone Regeneration Therapies: From Cell Transplantation and Tissue Engineering to Therapeutic Secretomes and Extracellular Vesicles |
| title_full | Mesenchymal Stromal Cell-Based Bone Regeneration Therapies: From Cell Transplantation and Tissue Engineering to Therapeutic Secretomes and Extracellular Vesicles |
| title_fullStr | Mesenchymal Stromal Cell-Based Bone Regeneration Therapies: From Cell Transplantation and Tissue Engineering to Therapeutic Secretomes and Extracellular Vesicles |
| title_full_unstemmed | Mesenchymal Stromal Cell-Based Bone Regeneration Therapies: From Cell Transplantation and Tissue Engineering to Therapeutic Secretomes and Extracellular Vesicles |
| title_short | Mesenchymal Stromal Cell-Based Bone Regeneration Therapies: From Cell Transplantation and Tissue Engineering to Therapeutic Secretomes and Extracellular Vesicles |
| title_sort | mesenchymal stromal cell based bone regeneration therapies from cell transplantation and tissue engineering to therapeutic secretomes and extracellular vesicles |
| topic | mesenchymal stromal cells stem cells MSCs secretome extracellular vesicles cell therapy |
| url | https://www.frontiersin.org/article/10.3389/fbioe.2019.00352/full |
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