Effects of Panax ginseng extract in patients with fibromyalgia: a 12-week, randomized, double-blind, placebo-controlled trial
The purpose of the study was to evaluate the efficacy of an extract of Panax ginseng in patients with fibromyalgia. A randomized, double-blind, controlled clinical trial was carried out over 12 weeks to compare the effects of P. ginseng (100 mg/d) with amitriptyline (25 mg/d) and placebo in 38 patie...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Psiquiatria (ABP)
2013-03-01
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| Series: | Brazilian Journal of Psychiatry |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462013000100005 |
| _version_ | 1818523865166381056 |
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| author | Alessandra S. Braz Liana Clébia S. Morais Ana Patríca Paula Margareth F. F. M. Diniz Reinaldo N. Almeida |
| author_facet | Alessandra S. Braz Liana Clébia S. Morais Ana Patríca Paula Margareth F. F. M. Diniz Reinaldo N. Almeida |
| author_sort | Alessandra S. Braz |
| collection | DOAJ |
| description | The purpose of the study was to evaluate the efficacy of an extract of Panax ginseng in patients with fibromyalgia. A randomized, double-blind, controlled clinical trial was carried out over 12 weeks to compare the effects of P. ginseng (100 mg/d) with amitriptyline (25 mg/d) and placebo in 38 patients with fibromyalgia: 13 in Group I (amitriptyline), 13 in Group II (placebo), and 12 in Group III (P. ginseng). Ratings on the Visual Analogue Scale (VAS) revealed a reduction in pain in the P. ginseng group (p < .0001), an improvement in fatigue (p < .0001) and an improvement in sleep (p < .001), with respect to baseline characteristics, but there were no differences between the three groups. With respect to anxiety, improvements occurred in the P. ginseng group compared to baseline (p < .0001); however, amitriptyline treatment resulted in significantly greater improvements (p < .05). P. ginseng reduced the number of tender points and improved patients' quality of life (using the Fibromyalgia Impact Questionnaire - FIQ); however, there were no differences between groups. The beneficial effects experienced by patients for all parameters suggest a need for further studies to be performed on the tolerability and efficacy of this phytotherapic as a complementary therapy for fibromyalgia. |
| first_indexed | 2024-12-11T05:49:56Z |
| format | Article |
| id | doaj.art-0f6af3443f45408ea8aebcc4d8df96f8 |
| institution | Directory Open Access Journal |
| issn | 1516-4446 1809-452X |
| language | English |
| last_indexed | 2024-12-11T05:49:56Z |
| publishDate | 2013-03-01 |
| publisher | Associação Brasileira de Psiquiatria (ABP) |
| record_format | Article |
| series | Brazilian Journal of Psychiatry |
| spelling | doaj.art-0f6af3443f45408ea8aebcc4d8df96f82022-12-22T01:18:51ZengAssociação Brasileira de Psiquiatria (ABP)Brazilian Journal of Psychiatry1516-44461809-452X2013-03-013512128Effects of Panax ginseng extract in patients with fibromyalgia: a 12-week, randomized, double-blind, placebo-controlled trialAlessandra S. BrazLiana Clébia S. MoraisAna Patríca PaulaMargareth F. F. M. DinizReinaldo N. AlmeidaThe purpose of the study was to evaluate the efficacy of an extract of Panax ginseng in patients with fibromyalgia. A randomized, double-blind, controlled clinical trial was carried out over 12 weeks to compare the effects of P. ginseng (100 mg/d) with amitriptyline (25 mg/d) and placebo in 38 patients with fibromyalgia: 13 in Group I (amitriptyline), 13 in Group II (placebo), and 12 in Group III (P. ginseng). Ratings on the Visual Analogue Scale (VAS) revealed a reduction in pain in the P. ginseng group (p < .0001), an improvement in fatigue (p < .0001) and an improvement in sleep (p < .001), with respect to baseline characteristics, but there were no differences between the three groups. With respect to anxiety, improvements occurred in the P. ginseng group compared to baseline (p < .0001); however, amitriptyline treatment resulted in significantly greater improvements (p < .05). P. ginseng reduced the number of tender points and improved patients' quality of life (using the Fibromyalgia Impact Questionnaire - FIQ); however, there were no differences between groups. The beneficial effects experienced by patients for all parameters suggest a need for further studies to be performed on the tolerability and efficacy of this phytotherapic as a complementary therapy for fibromyalgia.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462013000100005FibromyalgiaPanax ginsengPharmacological TreatmentComplementary TreatmentPhytotherapy |
| spellingShingle | Alessandra S. Braz Liana Clébia S. Morais Ana Patríca Paula Margareth F. F. M. Diniz Reinaldo N. Almeida Effects of Panax ginseng extract in patients with fibromyalgia: a 12-week, randomized, double-blind, placebo-controlled trial Brazilian Journal of Psychiatry Fibromyalgia Panax ginseng Pharmacological Treatment Complementary Treatment Phytotherapy |
| title | Effects of Panax ginseng extract in patients with fibromyalgia: a 12-week, randomized, double-blind, placebo-controlled trial |
| title_full | Effects of Panax ginseng extract in patients with fibromyalgia: a 12-week, randomized, double-blind, placebo-controlled trial |
| title_fullStr | Effects of Panax ginseng extract in patients with fibromyalgia: a 12-week, randomized, double-blind, placebo-controlled trial |
| title_full_unstemmed | Effects of Panax ginseng extract in patients with fibromyalgia: a 12-week, randomized, double-blind, placebo-controlled trial |
| title_short | Effects of Panax ginseng extract in patients with fibromyalgia: a 12-week, randomized, double-blind, placebo-controlled trial |
| title_sort | effects of panax ginseng extract in patients with fibromyalgia a 12 week randomized double blind placebo controlled trial |
| topic | Fibromyalgia Panax ginseng Pharmacological Treatment Complementary Treatment Phytotherapy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462013000100005 |
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