Single-Shot Local Injection of Microfragmented Fat Tissue Loaded with Paclitaxel Induces Potent Growth Inhibition of Hepatocellular Carcinoma in Nude Mice

Single-Shot Local Injection of Microfragmented Fat Tissue Loaded with Paclitaxel Induces Potent Growth Inhibition of Hepatocellular Carcinoma in Nude Mice

Hepatocellular carcinoma (HCC) is poorly beneficiated by intravenous chemotherapy due to inadequate availability of drugs at the tumor site. We previously demonstrated that human micro-fragmented adipose tissue (MFAT) and its devitalized counterpart (DMFAT) could be effective natural scaffolds to de...

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Bibliographic Details
Main Authors: Giulio Alessandri, Augusto Pessina, Rita Paroni, Luisa Bercich, Francesca Paino, Michele Dei Cas, Moris Cadei, Arnaldo Caruso, Marco Schiariti, Francesco Restelli, Offer Zeira, Carlo Tremolada, Nazario Portolani
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cancers
Subjects:
paclitaxel
micro-fragmented fat tissue
hepatocarcinoma
drug delivery
natural scaffold
Online Access:https://www.mdpi.com/2072-6694/13/21/5505

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