Systematic Review of the Preclinical Technology Readiness of Orthopedic Gene Therapy and Outlook for Clinical Translation

Systematic Review of the Preclinical Technology Readiness of Orthopedic Gene Therapy and Outlook for Clinical Translation

Bone defects and improper healing of fractures are an increasing public health burden, and there is an unmet clinical need in their successful repair. Gene therapy has been proposed as a possible approach to improve or augment bone healing with the potential to provide true functional regeneration....

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Bibliographic Details
Main Authors: Piers Wilkinson, Ilya Y. Bozo, Thomas Braxton, Peter Just, Elena Jones, Roman V. Deev, Peter V. Giannoudis, Georg A. Feichtinger
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
bone regeneration
gene therapy
preclinical models
translational medical research
orthopedic and trauma
regenerative medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.626315/full

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