Stratum corneum lipids: specificity, role, deficiencies and modulation
Lipids are important constituents of the human epidermis. Either free and organized into broad lipid bilayers in the intercorneocytes spaces, or covalently bound to the corneocyte envelope, they play a crucial role in permeability barrier function. This article presents the structures of various hum...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2004-11-01
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| Series: | Oléagineux, Corps gras, Lipides |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1051/ocl.2004.0401 |
| _version_ | 1818613762775580672 |
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| author | Castiel-Higounenc Isabelle Chopart M. Ferraris C. |
| author_facet | Castiel-Higounenc Isabelle Chopart M. Ferraris C. |
| author_sort | Castiel-Higounenc Isabelle |
| collection | DOAJ |
| description | Lipids are important constituents of the human epidermis. Either free and organized into broad lipid bilayers in the intercorneocytes spaces, or covalently bound to the corneocyte envelope, they play a crucial role in permeability barrier function. This article presents the structures of various human skin ceramides, their role in the maintenance of skin barrier function and homeostasis, and their qualitative and quantitative changes in some cases of dry skin or atopic xerosis. Moreover, we show that reconstructed human skin models could provide valuable tools to assess in vitro the biological interest of active compounds on epidermal lipogenesis. Based on such in vitro studies, we assume that the association of vitamin C and some exogenous sphingolipid could enhance the endogenous ceramide content deficient in some cases of atopic dry skin. |
| first_indexed | 2024-12-16T16:07:17Z |
| format | Article |
| id | doaj.art-0f6cc3145bc349a5ba0db69b6308b725 |
| institution | Directory Open Access Journal |
| issn | 1258-8210 1950-697X |
| language | English |
| last_indexed | 2024-12-16T16:07:17Z |
| publishDate | 2004-11-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | Oléagineux, Corps gras, Lipides |
| spelling | doaj.art-0f6cc3145bc349a5ba0db69b6308b7252022-12-21T22:25:20ZengEDP SciencesOléagineux, Corps gras, Lipides1258-82101950-697X2004-11-0111640140610.1051/ocl.2004.0401ocl2004116p401Stratum corneum lipids: specificity, role, deficiencies and modulationCastiel-Higounenc IsabelleChopart M.Ferraris C.Lipids are important constituents of the human epidermis. Either free and organized into broad lipid bilayers in the intercorneocytes spaces, or covalently bound to the corneocyte envelope, they play a crucial role in permeability barrier function. This article presents the structures of various human skin ceramides, their role in the maintenance of skin barrier function and homeostasis, and their qualitative and quantitative changes in some cases of dry skin or atopic xerosis. Moreover, we show that reconstructed human skin models could provide valuable tools to assess in vitro the biological interest of active compounds on epidermal lipogenesis. Based on such in vitro studies, we assume that the association of vitamin C and some exogenous sphingolipid could enhance the endogenous ceramide content deficient in some cases of atopic dry skin.http://dx.doi.org/10.1051/ocl.2004.0401lipidsceramideskin barrier functionvitamin Catopydry skin |
| spellingShingle | Castiel-Higounenc Isabelle Chopart M. Ferraris C. Stratum corneum lipids: specificity, role, deficiencies and modulation Oléagineux, Corps gras, Lipides lipids ceramide skin barrier function vitamin C atopy dry skin |
| title | Stratum corneum lipids: specificity, role, deficiencies and modulation |
| title_full | Stratum corneum lipids: specificity, role, deficiencies and modulation |
| title_fullStr | Stratum corneum lipids: specificity, role, deficiencies and modulation |
| title_full_unstemmed | Stratum corneum lipids: specificity, role, deficiencies and modulation |
| title_short | Stratum corneum lipids: specificity, role, deficiencies and modulation |
| title_sort | stratum corneum lipids specificity role deficiencies and modulation |
| topic | lipids ceramide skin barrier function vitamin C atopy dry skin |
| url | http://dx.doi.org/10.1051/ocl.2004.0401 |
| work_keys_str_mv | AT castielhigounencisabelle stratumcorneumlipidsspecificityroledeficienciesandmodulation AT chopartm stratumcorneumlipidsspecificityroledeficienciesandmodulation AT ferrarisc stratumcorneumlipidsspecificityroledeficienciesandmodulation |