Cryptococcus neoformans Strains and Infection in Apparently Immunocompetent Patients, China
To determine the population structure of the cryptococcosis agents in China, we analyzed the genotype of 120 Cryptococcus neoformans and 9 Cryptococcus gattii strains isolated from 1980 through 2006 from cryptococcosis patients residing in 16 provinces of mainland China. A total of 71% (91/129) of t...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2008-05-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/14/5/07-1312_article |
| _version_ | 1828423185320640512 |
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| author | Jianghan Chen Ashok Varma Mara R. Diaz Anastasia P. Litvintseva Kurt K. Wollenberg Kyung J. Kwon-Chung |
| author_facet | Jianghan Chen Ashok Varma Mara R. Diaz Anastasia P. Litvintseva Kurt K. Wollenberg Kyung J. Kwon-Chung |
| author_sort | Jianghan Chen |
| collection | DOAJ |
| description | To determine the population structure of the cryptococcosis agents in China, we analyzed the genotype of 120 Cryptococcus neoformans and 9 Cryptococcus gattii strains isolated from 1980 through 2006 from cryptococcosis patients residing in 16 provinces of mainland China. A total of 71% (91/129) of the clinical strains isolated from 1985 through 2006 were from patients without any apparent risk factors. Only 8.5% (11/129) were from AIDS patients; the remaining 20.5% (27/129) were from patients with underlying diseases other than HIV infection. One hundred twenty of the 129 isolates were C. neoformans serotype A, mating type MATα strains that exhibited an identical M13-based VNI subtype, which was distinguishable from the reference VNI molecular type. The 9 remaining isolates were serotype B, MATα strains of C. gattii and portrayed a typical VGI molecular type. Data analyzed from multilocus sequences showed no variation and that these Chinese C. neoformans isolates belong to a cluster that has phylogenetically diverged from the VNI reference strain. Our finding that most cryptococcosis patients in China had no apparent risk factor is in stark contrast with reports from other countries. |
| first_indexed | 2024-12-10T15:57:46Z |
| format | Article |
| id | doaj.art-0f6cce30dafc4369a210eb62dc30ee24 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-10T15:57:46Z |
| publishDate | 2008-05-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-0f6cce30dafc4369a210eb62dc30ee242022-12-22T01:42:33ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592008-05-0114575576210.3201/eid1405.071312Cryptococcus neoformans Strains and Infection in Apparently Immunocompetent Patients, ChinaJianghan ChenAshok VarmaMara R. DiazAnastasia P. LitvintsevaKurt K. WollenbergKyung J. Kwon-ChungTo determine the population structure of the cryptococcosis agents in China, we analyzed the genotype of 120 Cryptococcus neoformans and 9 Cryptococcus gattii strains isolated from 1980 through 2006 from cryptococcosis patients residing in 16 provinces of mainland China. A total of 71% (91/129) of the clinical strains isolated from 1985 through 2006 were from patients without any apparent risk factors. Only 8.5% (11/129) were from AIDS patients; the remaining 20.5% (27/129) were from patients with underlying diseases other than HIV infection. One hundred twenty of the 129 isolates were C. neoformans serotype A, mating type MATα strains that exhibited an identical M13-based VNI subtype, which was distinguishable from the reference VNI molecular type. The 9 remaining isolates were serotype B, MATα strains of C. gattii and portrayed a typical VGI molecular type. Data analyzed from multilocus sequences showed no variation and that these Chinese C. neoformans isolates belong to a cluster that has phylogenetically diverged from the VNI reference strain. Our finding that most cryptococcosis patients in China had no apparent risk factor is in stark contrast with reports from other countries.https://wwwnc.cdc.gov/eid/article/14/5/07-1312_articleCryptococcosisChinaAIDSCryptococcus neoformansC. gattiimolecular strain type |
| spellingShingle | Jianghan Chen Ashok Varma Mara R. Diaz Anastasia P. Litvintseva Kurt K. Wollenberg Kyung J. Kwon-Chung Cryptococcus neoformans Strains and Infection in Apparently Immunocompetent Patients, China Emerging Infectious Diseases Cryptococcosis China AIDS Cryptococcus neoformans C. gattii molecular strain type |
| title | Cryptococcus neoformans Strains and Infection in Apparently Immunocompetent Patients, China |
| title_full | Cryptococcus neoformans Strains and Infection in Apparently Immunocompetent Patients, China |
| title_fullStr | Cryptococcus neoformans Strains and Infection in Apparently Immunocompetent Patients, China |
| title_full_unstemmed | Cryptococcus neoformans Strains and Infection in Apparently Immunocompetent Patients, China |
| title_short | Cryptococcus neoformans Strains and Infection in Apparently Immunocompetent Patients, China |
| title_sort | cryptococcus neoformans strains and infection in apparently immunocompetent patients china |
| topic | Cryptococcosis China AIDS Cryptococcus neoformans C. gattii molecular strain type |
| url | https://wwwnc.cdc.gov/eid/article/14/5/07-1312_article |
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