Distribution of emm genotypes in group A streptococcus isolates of Korean children from 2012 to 2019
Objectives: Changes in the epidemiology of group A streptococcus (GAS) infection is related to emm genotype. We studied the distribution of emm genotypes and their antibiotic susceptibility among Korean children. Methods: Isolates from children with GAS infection between 2012 and 2019 were collected...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Journal of Microbiology, Immunology and Infection |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S168411822200069X |
| _version_ | 1828432091914698752 |
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| author | You Na Cho Su Eun Park Eun Young Cho Hye Kyung Cho Ji Young Park Hyun-Mi Kang Ki Wook Yun Eun Hwa Choi Hyunju Lee |
| author_facet | You Na Cho Su Eun Park Eun Young Cho Hye Kyung Cho Ji Young Park Hyun-Mi Kang Ki Wook Yun Eun Hwa Choi Hyunju Lee |
| author_sort | You Na Cho |
| collection | DOAJ |
| description | Objectives: Changes in the epidemiology of group A streptococcus (GAS) infection is related to emm genotype. We studied the distribution of emm genotypes and their antibiotic susceptibility among Korean children. Methods: Isolates from children with GAS infection between 2012 and 2019 were collected. emm typing and cluster analysis was performed according to the Centers for Disease Control emm cluster classification. Antimicrobial susceptibility was tested using the E-test and resistance genes were analyzed for macrolide resistant phenotypes. Results: Among 169 GAS isolates, 115 were from children with scarlet fever. Among invasive isolates, emm1 (6/22, 27.3%), emm12 (4/22, 18.2%), and emm4 (4/22, 18.2%) were most common. In scarlet fever, although emm4 (38/115, 33.0%) was the most prevalent throughout the study period, emm4 was replaced by emm3 (28/90, 31.1%) during an outbreak in 2017–2018. Among all isolates, only 2 (1.2%) exhibited erythromycin resistance and harbored both ermA and ermB genes. Conclusions: In this analysis of GAS isolated from Korean children, emm1 was the most prevalent in invasive infection. In scarlet fever, emm4 was prevalent throughout the study period, with an increase in emm3 during 2017–2018. GAS isolates during 2012–2019 demonstrated low erythromycin resistance. |
| first_indexed | 2024-12-10T18:13:57Z |
| format | Article |
| id | doaj.art-0f6f00384c184e1bbafa2441685a0731 |
| institution | Directory Open Access Journal |
| issn | 1684-1182 |
| language | English |
| last_indexed | 2024-12-10T18:13:57Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Microbiology, Immunology and Infection |
| spelling | doaj.art-0f6f00384c184e1bbafa2441685a07312022-12-22T01:38:22ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822022-08-01554671677Distribution of emm genotypes in group A streptococcus isolates of Korean children from 2012 to 2019You Na Cho0Su Eun Park1Eun Young Cho2Hye Kyung Cho3Ji Young Park4Hyun-Mi Kang5Ki Wook Yun6Eun Hwa Choi7Hyunju Lee8Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Pediatrics, Pusan National University Children's Hospital, Yangsan, Republic of KoreaDepartment of Pediatrics, Chungnam National University Hospital, Daejeon, Republic of KoreaDepartment of Pediatrics, Gachon University College of Medicine, Incheon, Republic of KoreaDepartment of Pediatrics, Chung-Ang University Hospital, Seoul, Republic of KoreaDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of KoreaDepartment of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of KoreaDepartment of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Republic of Korea; Corresponding author. Department of Pediatrics, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Gumi-ro, 173 Beon-gil 82, Bundang-gu, Seongnam, 13620, Republic of Korea. Fax: +82 31-787-4054.Objectives: Changes in the epidemiology of group A streptococcus (GAS) infection is related to emm genotype. We studied the distribution of emm genotypes and their antibiotic susceptibility among Korean children. Methods: Isolates from children with GAS infection between 2012 and 2019 were collected. emm typing and cluster analysis was performed according to the Centers for Disease Control emm cluster classification. Antimicrobial susceptibility was tested using the E-test and resistance genes were analyzed for macrolide resistant phenotypes. Results: Among 169 GAS isolates, 115 were from children with scarlet fever. Among invasive isolates, emm1 (6/22, 27.3%), emm12 (4/22, 18.2%), and emm4 (4/22, 18.2%) were most common. In scarlet fever, although emm4 (38/115, 33.0%) was the most prevalent throughout the study period, emm4 was replaced by emm3 (28/90, 31.1%) during an outbreak in 2017–2018. Among all isolates, only 2 (1.2%) exhibited erythromycin resistance and harbored both ermA and ermB genes. Conclusions: In this analysis of GAS isolated from Korean children, emm1 was the most prevalent in invasive infection. In scarlet fever, emm4 was prevalent throughout the study period, with an increase in emm3 during 2017–2018. GAS isolates during 2012–2019 demonstrated low erythromycin resistance.http://www.sciencedirect.com/science/article/pii/S168411822200069XStreptococcus pyogenesMolecular epidemiologyScarlet feverChildStreptococcal M protein |
| spellingShingle | You Na Cho Su Eun Park Eun Young Cho Hye Kyung Cho Ji Young Park Hyun-Mi Kang Ki Wook Yun Eun Hwa Choi Hyunju Lee Distribution of emm genotypes in group A streptococcus isolates of Korean children from 2012 to 2019 Journal of Microbiology, Immunology and Infection Streptococcus pyogenes Molecular epidemiology Scarlet fever Child Streptococcal M protein |
| title | Distribution of emm genotypes in group A streptococcus isolates of Korean children from 2012 to 2019 |
| title_full | Distribution of emm genotypes in group A streptococcus isolates of Korean children from 2012 to 2019 |
| title_fullStr | Distribution of emm genotypes in group A streptococcus isolates of Korean children from 2012 to 2019 |
| title_full_unstemmed | Distribution of emm genotypes in group A streptococcus isolates of Korean children from 2012 to 2019 |
| title_short | Distribution of emm genotypes in group A streptococcus isolates of Korean children from 2012 to 2019 |
| title_sort | distribution of emm genotypes in group a streptococcus isolates of korean children from 2012 to 2019 |
| topic | Streptococcus pyogenes Molecular epidemiology Scarlet fever Child Streptococcal M protein |
| url | http://www.sciencedirect.com/science/article/pii/S168411822200069X |
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