Acute cigarette smoke exposure leads to higher viral infection in human bronchial epithelial cultures by altering interferon, glycolysis and GDF15-related pathways

Acute cigarette smoke exposure leads to higher viral infection in human bronchial epithelial cultures by altering interferon, glycolysis and GDF15-related pathways

Abstract Background Acute exacerbations of chronic inflammatory lung diseases, such as chronic obstructive pulmonary disease (COPD), are frequently associated with rhinovirus (RV) infections. Despite these associations, the pathogenesis of virus-induced exacerbations is incompletely understood. We a...

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Bibliographic Details
Main Authors: Ying Wang, Dennis K. Ninaber, Alen Faiz, Abraham C. van der Linden, Annemarie van Schadewijk, René Lutter, Pieter S. Hiemstra, Anne M. van der Does, Abilash Ravi
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Respiratory Research
Subjects:
Bronchial epithelium
Cigarette smoke
Rhinovirus infection
Chronic obstructive pulmonary disease (COPD)
RNA-Seq
Online Access:https://doi.org/10.1186/s12931-023-02511-5

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