Autoantibody Formation and Mapping of Immunogenic Epitopes against Cold-Shock-Protein YB-1 in Cancer Patients and Healthy Controls

Autoantibody Formation and Mapping of Immunogenic Epitopes against Cold-Shock-Protein YB-1 in Cancer Patients and Healthy Controls

Cold shock Y-box binding protein-1 participates in cancer cell transformation and mediates invasive cell growth. It is unknown whether an autoimmune response against cancerous human YB-1 with posttranslational protein modifications or processing develops. We performed a systematic analysis for autoa...

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Bibliographic Details
Main Authors: Ronnie Morgenroth, Charlotte Reichardt, Johannes Steffen, Stefan Busse, Ronald Frank, Harald Heidecke, Peter R. Mertens
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
cold shock proteins
autoantibody
peptide array
protein cleavage
antigenicity
Online Access:https://www.mdpi.com/2072-6694/12/12/3507

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