Universal clinical Parkinson’s disease axes identify a major influence of neuroinflammation

Universal clinical Parkinson’s disease axes identify a major influence of neuroinflammation

Abstract Background There is large individual variation in both clinical presentation and progression between Parkinson’s disease patients. Generation of deeply and longitudinally phenotyped patient cohorts has enormous potential to identify disease subtypes for prognosis and therapeutic targeting....

Full description

Bibliographic Details
Main Authors:	Cynthia Sandor, Stephanie Millin, Andrew Dahl, Ann-Kathrin Schalkamp, Michael Lawton, Leon Hubbard, Nabila Rahman, Nigel Williams, Yoav Ben-Shlomo, Donald G. Grosset, Michele T. Hu, Jonathan Marchini, Caleb Webber
Format:	Article
Language:	English
Published:	BMC 2022-11-01
Series:	Genome Medicine
Subjects:	Parkinson’s disease Deeply phenotyped cohorts Neuro-inflammation
Online Access:	https://doi.org/10.1186/s13073-022-01132-9

Similar Items

Deep phenotyping for precision medicine in Parkinson's disease
by: Ann-Kathrin Schalkamp, et al.
Published: (2022-06-01)

Female Sexual Function in Women with Suspected Deep Infiltrating Endometriosis
by: Ryane Vieira Lima, et al.
Published: (2018-03-01)

SQNet: Simple and Fast Model for Ocean Front Identification
by: Rui Niu, et al.
Published: (2023-04-01)

Hypothermic death resulting from extreme freezing with characteristic postmortem computed tomography findings: A case report and review of the literature
by: Hiroyuki Tokue, MD, et al.
Published: (2023-04-01)

Commentary: “Association between diabetes mellitus, prediabetes and risk, disease progression of Parkinson's disease: a systematic review and meta-analysis”
by: Michael Lawton, et al.
Published: (2023-06-01)

Accuracy of magnetic resonance imaging in diagnosis of deeply infiltrating endometriosis
by: Mohamed Fouad Sherif, et al.
Published: (2015-03-01)

The Individualisation of Discontinuities in Deeply Disadvantaged Areas of Romania
by: DANIEL PEPTENATU, et al.
Published: (2009-01-01)

A Parameter Self-Calibration Method for GNSS/INS Deeply Coupled Navigation Systems in Highly Dynamic Environments
by: Zang Chen, et al.
Published: (2018-07-01)

An Overview of Deeply Optimized Convolutional Neural Networks and Research in Surface Defect Classification of Workpieces
by: Quanyang Li, et al.
Published: (2022-01-01)

Vertical distribution of soil seed bank and the ecological importance of deeply buried seeds in alkaline grasslands
by: Ágnes Tóth, et al.
Published: (2022-04-01)

Remote Sensing Image Augmentation Based on Text Description for Waterside Change Detection
by: Chen Chen, et al.
Published: (2021-05-01)

A laboratory-testing-based study on mechanical properties and dilatancy characteristics of deeply buried mudstone under different stress loading rates
by: Ke LI, et al.
Published: (2023-09-01)

A Cross-Layer Framework for Designing and Optimizing Deeply-Scaled FinFET-Based Cache Memories
by: Alireza Shafaei, et al.
Published: (2015-08-01)

Chinese Studies on the Logic of Natural Language
by: Chongli Zou, et al.
Published: (2022-05-01)

Pavement Crack Detection Algorithm Based on Densely Connected and Deeply Supervised Network
by: Haifeng Li, et al.
Published: (2021-01-01)

PIEZO1 expression at the glio-vascular unit adjusts to neuroinflammation in seizure conditions
by: Valentin Garcia, et al.
Published: (2023-10-01)

A Method for Calculating the Instability Probability in a Deeply Buried Tunnel Construction with a Hidden Karst Cave at the Bottom
by: Bo Wu, et al.
Published: (2024-02-01)

A More Diverse Cervical Microbiome Associates with Better Clinical Outcomes in Patients with Endometriosis: A Pilot Study
by: Cherry Yin-Yi Chang, et al.
Published: (2022-01-01)

High-fidelity formation of deeply bound ultracold molecules via non-Hermitian shortcut to adiabaticity
by: Jia-Hui Zhang, et al.
Published: (2021-01-01)

Comparison of maternal and neonatal complications of fetal delivery by cesarean section in three methods: cephalic, breech and anterior shoulder in deeply engaged fetal head
by: Farideh Akhlaghi, et al.
Published: (2023-03-01)

Issues on health status and rehabilitation of young children born with extremely low and very low weight
by: Scherbatyuk E.S., et al.
Published: (2017-06-01)

The Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early Diagnosis
by: Geraldine Hipp, et al.
Published: (2018-10-01)

Microglia Mediated Neuroinflammation in Parkinson’s Disease
by: Sevim Isik, et al.
Published: (2023-03-01)

The Involvement of Neuroinflammation in the Onset and Progression of Parkinson’s Disease
by: Anamaria Jurcau, et al.
Published: (2023-09-01)

FAILURE OF FOLLICULAR STIMULATION AND OESTRUS INDUCTION WITH SYNTHETIC GONADOTROPIN RELEASING HORMONE AND PROGESTERONE IN DEEPLY ANOSTRUS ARABIAN MARES
by: ABDUL-AZIZ F.R.
Published: (1989-12-01)

Application of three-dimensional visualization modeling technology of ore bodies in metallogenic mode analysis
by: Ji Tang, et al.
Published: (2023-09-01)

The Dilemma and Breakthrough of Professional Ethics Education for Higher Vocational Accounting Professionals in the Internet Era
by: Chen Xuemei, et al.
Published: (2024-01-01)

Investigation of spectroscopic factors of deeply-bound nucleons in drip-line nuclei with the Gamow shell model
by: M.R. Xie, et al.
Published: (2023-04-01)

The Aging Study of Pyeongchang Rural Area (ASPRA): Findings and Perspectives for Human Aging, Frailty, and Disability
by: Ji Yeon Baek, et al.
Published: (2021-09-01)

3D scanning and modeling of highly detailed and geometrically complex historical architectural objects: the example of the Juma Mosque in Khiva (Uzbekistan)
by: Marek Milosz, et al.
Published: (2024-03-01)

The Spatiotemporal Distribution Law of Microseismic Events and Rockburst Characteristics of the Deeply Buried Tunnel Group
by: Heng Zhang, et al.
Published: (2018-11-01)

The Prevention and Control Mechanism of Rockburst Hazards and Its Application in the Construction of a Deeply Buried Tunnel
by: Heng Zhang, et al.
Published: (2019-09-01)

Expansion of Blast Vibration Attenuation Equations for Deeply Buried Small Clearance Tunnels Based on Dimensional Analysis
by: Jian-Jun Shi, et al.
Published: (2022-06-01)

Prediction of Microvascular Invasion of Hepatocellular Carcinoma Based on Contrast-Enhanced MR and 3D Convolutional Neural Networks
by: Wu Zhou, et al.
Published: (2021-03-01)

Research on the heat exchange characteristics of the deeply buried pipe type of energy pile
by: Zhi Chen, et al.
Published: (2021-10-01)

Microwave Waveguide‐Type Hyperbolic Metamaterials
by: Jichao Fu, et al.
Published: (2021-02-01)

Intranasal Delivery: Effects on the Neuroimmune Axes and Treatment of Neuroinflammation
by: Elizabeth M. Rhea, et al.
Published: (2020-11-01)

Research on Heat Exchange Law and Structural Design Optimization of Deep Buried Pipe Energy Piles
by: Zhi Chen, et al.
Published: (2021-10-01)

Cytologic diagnosis of gastric submucosal lesions by endoscopic ultrasound-guided fine-needle aspiration: A single center experience in Saudi Arabia
by: Emad Raddaoui, et al.
Published: (2015-01-01)

Editorial: Neuro-immune interactions and neuroinflammation in neurocritical care
by: Suyue Pan, et al.
Published: (2023-01-01)