Hyaluronic Acid-Coated MTX-PEI Nanoparticles for Targeted Rheumatoid Arthritis Therapy
Methotrexate (MTX) is an anchor drug for the treatment of rheumatoid arthritis (RA); however, long-term and high-dose usage of MTX for patients can cause many side effects and toxic reactions. To address these difficulties, selectively delivering MTX to the inflammatory site of a joint is promising...
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| Format: | Article |
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MDPI AG
2021-03-01
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| Series: | Crystals |
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| Online Access: | https://www.mdpi.com/2073-4352/11/4/321 |
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| author | Shenghui Zhong Peng Liu Jinsong Ding Wenhu Zhou |
| author_facet | Shenghui Zhong Peng Liu Jinsong Ding Wenhu Zhou |
| author_sort | Shenghui Zhong |
| collection | DOAJ |
| description | Methotrexate (MTX) is an anchor drug for the treatment of rheumatoid arthritis (RA); however, long-term and high-dose usage of MTX for patients can cause many side effects and toxic reactions. To address these difficulties, selectively delivering MTX to the inflammatory site of a joint is promising in the treatment of RA. In this study, we prepared MTX-PEI@HA nanoparticles (NPs), composed of hyaluronic acid (HA) as the hydrophilic negative electrical shell, and MTX-linked branched polyethyleneimine (MTX-PEI) NPs as the core. MTX-PEI@HA NPs were prepared in the water phase by a one-pot method. The polymeric NPs were selectively internalized via CD44 receptor-mediated endocytosis in the activated macrophages. In the in vivo mice mode study, treatment with MTX-PEI@HA NPs mitigated inflammatory arthritis with notable safety at a high dose of MTX. We highlight the distinct advantages of aqueous-synthesized NPs coated with HA for arthritis-selective targeted delivery, thus verifying MTX-PEI@HA NPs as a promising MTX-based nanoplatform for treatment of RA. |
| first_indexed | 2024-03-10T12:55:46Z |
| format | Article |
| id | doaj.art-0f762d4871424e6f9c85136e18b6d45b |
| institution | Directory Open Access Journal |
| issn | 2073-4352 |
| language | English |
| last_indexed | 2024-03-10T12:55:46Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Crystals |
| spelling | doaj.art-0f762d4871424e6f9c85136e18b6d45b2023-11-21T11:51:31ZengMDPI AGCrystals2073-43522021-03-0111432110.3390/cryst11040321Hyaluronic Acid-Coated MTX-PEI Nanoparticles for Targeted Rheumatoid Arthritis TherapyShenghui Zhong0Peng Liu1Jinsong Ding2Wenhu Zhou3Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, Hunan, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, Hunan, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, Hunan, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, Hunan, ChinaMethotrexate (MTX) is an anchor drug for the treatment of rheumatoid arthritis (RA); however, long-term and high-dose usage of MTX for patients can cause many side effects and toxic reactions. To address these difficulties, selectively delivering MTX to the inflammatory site of a joint is promising in the treatment of RA. In this study, we prepared MTX-PEI@HA nanoparticles (NPs), composed of hyaluronic acid (HA) as the hydrophilic negative electrical shell, and MTX-linked branched polyethyleneimine (MTX-PEI) NPs as the core. MTX-PEI@HA NPs were prepared in the water phase by a one-pot method. The polymeric NPs were selectively internalized via CD44 receptor-mediated endocytosis in the activated macrophages. In the in vivo mice mode study, treatment with MTX-PEI@HA NPs mitigated inflammatory arthritis with notable safety at a high dose of MTX. We highlight the distinct advantages of aqueous-synthesized NPs coated with HA for arthritis-selective targeted delivery, thus verifying MTX-PEI@HA NPs as a promising MTX-based nanoplatform for treatment of RA.https://www.mdpi.com/2073-4352/11/4/321methotrexatepolyethyleneiminerheumatoid arthritisnanoparticlestarget therapy |
| spellingShingle | Shenghui Zhong Peng Liu Jinsong Ding Wenhu Zhou Hyaluronic Acid-Coated MTX-PEI Nanoparticles for Targeted Rheumatoid Arthritis Therapy Crystals methotrexate polyethyleneimine rheumatoid arthritis nanoparticles target therapy |
| title | Hyaluronic Acid-Coated MTX-PEI Nanoparticles for Targeted Rheumatoid Arthritis Therapy |
| title_full | Hyaluronic Acid-Coated MTX-PEI Nanoparticles for Targeted Rheumatoid Arthritis Therapy |
| title_fullStr | Hyaluronic Acid-Coated MTX-PEI Nanoparticles for Targeted Rheumatoid Arthritis Therapy |
| title_full_unstemmed | Hyaluronic Acid-Coated MTX-PEI Nanoparticles for Targeted Rheumatoid Arthritis Therapy |
| title_short | Hyaluronic Acid-Coated MTX-PEI Nanoparticles for Targeted Rheumatoid Arthritis Therapy |
| title_sort | hyaluronic acid coated mtx pei nanoparticles for targeted rheumatoid arthritis therapy |
| topic | methotrexate polyethyleneimine rheumatoid arthritis nanoparticles target therapy |
| url | https://www.mdpi.com/2073-4352/11/4/321 |
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