Factors Associated with Candidiasis in Pemphigus Vulgaris Patients: Results from a Retrospective Study in Two Second-Care Level Hospitals in Mexico
Background: Infections are a major cause of morbidity and mortality in patients with pemphigus vulgaris (PV). One of the most common infections in these patients is candidiasis. This is probably due to the use of systemic immunosuppressants, including oral and intravenous corticosteroids, mainly in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/8/12/521 |
| _version_ | 1797379204091740160 |
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| author | Andrés Tirado-Sánchez Alexandro Bonifaz María Guadalupe Frías De León |
| author_facet | Andrés Tirado-Sánchez Alexandro Bonifaz María Guadalupe Frías De León |
| author_sort | Andrés Tirado-Sánchez |
| collection | DOAJ |
| description | Background: Infections are a major cause of morbidity and mortality in patients with pemphigus vulgaris (PV). One of the most common infections in these patients is candidiasis. This is probably due to the use of systemic immunosuppressants, including oral and intravenous corticosteroids, mainly in megadoses (pulse therapy), although it is unknown if there are other associated factors, in addition to immunosuppressive treatment. We determine the factors associated with candidiasis in PV patients in two second-care level hospitals in Mexico. Methods: We reviewed 100 cases with PV. Cases were randomly selected from the databases of two second-care level hospitals between January 2010 and December 2019 (10 years). The primary endpoint was the incidence of candidiasis in patients with PV. Results: One hundred patients with PV were enrolled in this retrospective study. Candidiasis was observed in 79 patients (79%). A maximum corticosteroid dose of 55 mg/day during the last year (<i>p</i> = 0.001) and a higher neutrophil/lymphocyte ratio were associated with candidiasis in patients with PV (<i>p</i> = 0.001). Conclusion: Risk factors favoring candidiasis in patients with PV are not only related to the use of corticosteroids, but also to demographic factors, the activity of the disease, and the systemic inflammation associated with autoimmunity. |
| first_indexed | 2024-03-08T20:18:46Z |
| format | Article |
| id | doaj.art-0f776385895f421291b91eb582003b97 |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-08T20:18:46Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-0f776385895f421291b91eb582003b972023-12-22T14:46:29ZengMDPI AGTropical Medicine and Infectious Disease2414-63662023-12-0181252110.3390/tropicalmed8120521Factors Associated with Candidiasis in Pemphigus Vulgaris Patients: Results from a Retrospective Study in Two Second-Care Level Hospitals in MexicoAndrés Tirado-Sánchez0Alexandro Bonifaz1María Guadalupe Frías De León2Internal Medicine Department, Hospital General de Zona 30, Instituto Mexicano del Seguro Social, Mexico City 08300, MexicoLaboratorio de Micología, Hospital General de México, Mexico City 06720, MexicoUnidad de Investigación Biomédica, Hospital Regional de Alta Especialidad de Ixtapaluca, Ixtapaluca 56530, MexicoBackground: Infections are a major cause of morbidity and mortality in patients with pemphigus vulgaris (PV). One of the most common infections in these patients is candidiasis. This is probably due to the use of systemic immunosuppressants, including oral and intravenous corticosteroids, mainly in megadoses (pulse therapy), although it is unknown if there are other associated factors, in addition to immunosuppressive treatment. We determine the factors associated with candidiasis in PV patients in two second-care level hospitals in Mexico. Methods: We reviewed 100 cases with PV. Cases were randomly selected from the databases of two second-care level hospitals between January 2010 and December 2019 (10 years). The primary endpoint was the incidence of candidiasis in patients with PV. Results: One hundred patients with PV were enrolled in this retrospective study. Candidiasis was observed in 79 patients (79%). A maximum corticosteroid dose of 55 mg/day during the last year (<i>p</i> = 0.001) and a higher neutrophil/lymphocyte ratio were associated with candidiasis in patients with PV (<i>p</i> = 0.001). Conclusion: Risk factors favoring candidiasis in patients with PV are not only related to the use of corticosteroids, but also to demographic factors, the activity of the disease, and the systemic inflammation associated with autoimmunity.https://www.mdpi.com/2414-6366/8/12/521pemphigus vulgarisneutrophil/lymphocyte ratioplatelet/neutrophil ratiocorticosteroidscandidiasiscandidemia |
| spellingShingle | Andrés Tirado-Sánchez Alexandro Bonifaz María Guadalupe Frías De León Factors Associated with Candidiasis in Pemphigus Vulgaris Patients: Results from a Retrospective Study in Two Second-Care Level Hospitals in Mexico Tropical Medicine and Infectious Disease pemphigus vulgaris neutrophil/lymphocyte ratio platelet/neutrophil ratio corticosteroids candidiasis candidemia |
| title | Factors Associated with Candidiasis in Pemphigus Vulgaris Patients: Results from a Retrospective Study in Two Second-Care Level Hospitals in Mexico |
| title_full | Factors Associated with Candidiasis in Pemphigus Vulgaris Patients: Results from a Retrospective Study in Two Second-Care Level Hospitals in Mexico |
| title_fullStr | Factors Associated with Candidiasis in Pemphigus Vulgaris Patients: Results from a Retrospective Study in Two Second-Care Level Hospitals in Mexico |
| title_full_unstemmed | Factors Associated with Candidiasis in Pemphigus Vulgaris Patients: Results from a Retrospective Study in Two Second-Care Level Hospitals in Mexico |
| title_short | Factors Associated with Candidiasis in Pemphigus Vulgaris Patients: Results from a Retrospective Study in Two Second-Care Level Hospitals in Mexico |
| title_sort | factors associated with candidiasis in pemphigus vulgaris patients results from a retrospective study in two second care level hospitals in mexico |
| topic | pemphigus vulgaris neutrophil/lymphocyte ratio platelet/neutrophil ratio corticosteroids candidiasis candidemia |
| url | https://www.mdpi.com/2414-6366/8/12/521 |
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