A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells
GATA-binding protein 4 (GATA4) is reported to control cell proliferation in cancers. Here the authors show that GATA4’s pro-inflammatory secretome promotes the recruitment of immune cells such as CD8 + T cells to suppress tumour initiation and growth in a non-cell autonomous manner.
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-01-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-021-27731-5 |