A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells
GATA-binding protein 4 (GATA4) is reported to control cell proliferation in cancers. Here the authors show that GATA4’s pro-inflammatory secretome promotes the recruitment of immune cells such as CD8 + T cells to suppress tumour initiation and growth in a non-cell autonomous manner.
Bibliographic Details
| Main Authors: |
Rupesh S. Patel,
Rodrigo Romero,
Emma V. Watson,
Anthony C. Liang,
Megan Burger,
Peter M. K. Westcott,
Kim L. Mercer,
Roderick T. Bronson,
Eric C. Wooten,
Arjun Bhutkar,
Tyler Jacks,
Stephen J. Elledge |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-27731-5
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