β- Cell function in a sample of Iraqi Patients with type 2 diabetes mellitus Isam Noori Salman
Back ground: Type 2 diabetes is mostly due to impaired β-cell mass and dysfunction which expressed by Insulin secretion, sensitivity and resistance. Aim of study: to evaluate β- cell function in newly diagnosed and ongoing diabetics. Method: Eighty eight subjects enrolled in this study with a...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
College of Pharmacy / Mustansiriyah University
2018-06-01
|
| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/460 |
| _version_ | 1797223902123917312 |
|---|---|
| author | Isam Noori Salman |
| author_facet | Isam Noori Salman |
| author_sort | Isam Noori Salman |
| collection | DOAJ |
| description |
Back ground: Type 2 diabetes is mostly due to impaired β-cell mass and dysfunction which expressed by Insulin secretion, sensitivity and resistance.
Aim of study: to evaluate β- cell function in newly diagnosed and ongoing diabetics.
Method: Eighty eight subjects enrolled in this study with age range (30-59) years, (20) healthy individuals as controls group with mean age (42.95±9.80) years. (68) Diabetic Patients was divided into two groups, (26) newly diagnosed diabetic, mean age (45.81±8.16) years and (42) ongoing diabetics, mean age (49.33±6.64) year. "Fasting glucose", "lipid profile", "glycosylated hemoglobin", "C-peptide levels" were evaluated. Insulin secretion, sensitivity and resistance "HOMA B %", "HOMA S %"and "HOMA IR" respectively were estimated by "Homeostasis Model Assessment" "HOMA2 calculator program".
Results:"Insulin secretion" and "sensitivity" were found to be lower (P 0.001) in both groups of diabetes than that controls, while a high level of insulin resistance in both diabetic groups than controls (P>0.0001)."C-peptide" level is higher in "newly diagnosed" diabetics than" ongoing diabetics" and controls (p˂0.0001).
Conclusion: Patients with low c- peptide level has poor insulin reserve and may need insulin while patients with high level of c- peptide have good insulin reserve and not need insulin to control his blood glucose.
|
| first_indexed | 2024-04-24T13:44:36Z |
| format | Article |
| id | doaj.art-0f80a476f38540f58adaad15c6d07d19 |
| institution | Directory Open Access Journal |
| issn | 1815-0993 2959-183X |
| language | English |
| last_indexed | 2024-04-24T13:44:36Z |
| publishDate | 2018-06-01 |
| publisher | College of Pharmacy / Mustansiriyah University |
| record_format | Article |
| series | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| spelling | doaj.art-0f80a476f38540f58adaad15c6d07d192024-04-04T06:58:05ZengCollege of Pharmacy / Mustansiriyah UniversityAl-Mustansiriyah Journal of Pharmaceutical Sciences1815-09932959-183X2018-06-0118110.32947/ajps.v18i1.460β- Cell function in a sample of Iraqi Patients with type 2 diabetes mellitus Isam Noori SalmanIsam Noori Salman0National Diabetes Center/ AL-Mustansiriayh University Back ground: Type 2 diabetes is mostly due to impaired β-cell mass and dysfunction which expressed by Insulin secretion, sensitivity and resistance. Aim of study: to evaluate β- cell function in newly diagnosed and ongoing diabetics. Method: Eighty eight subjects enrolled in this study with age range (30-59) years, (20) healthy individuals as controls group with mean age (42.95±9.80) years. (68) Diabetic Patients was divided into two groups, (26) newly diagnosed diabetic, mean age (45.81±8.16) years and (42) ongoing diabetics, mean age (49.33±6.64) year. "Fasting glucose", "lipid profile", "glycosylated hemoglobin", "C-peptide levels" were evaluated. Insulin secretion, sensitivity and resistance "HOMA B %", "HOMA S %"and "HOMA IR" respectively were estimated by "Homeostasis Model Assessment" "HOMA2 calculator program". Results:"Insulin secretion" and "sensitivity" were found to be lower (P 0.001) in both groups of diabetes than that controls, while a high level of insulin resistance in both diabetic groups than controls (P>0.0001)."C-peptide" level is higher in "newly diagnosed" diabetics than" ongoing diabetics" and controls (p˂0.0001). Conclusion: Patients with low c- peptide level has poor insulin reserve and may need insulin while patients with high level of c- peptide have good insulin reserve and not need insulin to control his blood glucose. https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/460 |
| spellingShingle | Isam Noori Salman β- Cell function in a sample of Iraqi Patients with type 2 diabetes mellitus Isam Noori Salman Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| title | β- Cell function in a sample of Iraqi Patients with type 2 diabetes mellitus Isam Noori Salman |
| title_full | β- Cell function in a sample of Iraqi Patients with type 2 diabetes mellitus Isam Noori Salman |
| title_fullStr | β- Cell function in a sample of Iraqi Patients with type 2 diabetes mellitus Isam Noori Salman |
| title_full_unstemmed | β- Cell function in a sample of Iraqi Patients with type 2 diabetes mellitus Isam Noori Salman |
| title_short | β- Cell function in a sample of Iraqi Patients with type 2 diabetes mellitus Isam Noori Salman |
| title_sort | β cell function in a sample of iraqi patients with type 2 diabetes mellitus isam noori salman |
| url | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/460 |
| work_keys_str_mv | AT isamnoorisalman bcellfunctioninasampleofiraqipatientswithtype2diabetesmellitusisamnoorisalman |