Redox mechanisms of environmental toxicants on male reproductive function
Humans and wildlife, including domesticated animals, are exposed to a myriad of environmental contaminants that are derived from various human activities, including agricultural, household, cosmetic, pharmaceutical, and industrial products. Excessive exposure to pesticides, heavy metals, and phthala...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1333845/full |
| _version_ | 1797295122666225664 |
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| author | Tarique Hussain Tarique Hussain Elsayed Metwally Ghulam Murtaza Dildar Hussain Kalhoro Muhammad Ismail Chughtai Bie Tan Ali Dogan Omur Shakeel Ahmed Tunio Muhammad Shahzad Akbar Muhammad Saleem Kalhoro |
| author_facet | Tarique Hussain Tarique Hussain Elsayed Metwally Ghulam Murtaza Dildar Hussain Kalhoro Muhammad Ismail Chughtai Bie Tan Ali Dogan Omur Shakeel Ahmed Tunio Muhammad Shahzad Akbar Muhammad Saleem Kalhoro |
| author_sort | Tarique Hussain |
| collection | DOAJ |
| description | Humans and wildlife, including domesticated animals, are exposed to a myriad of environmental contaminants that are derived from various human activities, including agricultural, household, cosmetic, pharmaceutical, and industrial products. Excessive exposure to pesticides, heavy metals, and phthalates consequently causes the overproduction of reactive oxygen species. The equilibrium between reactive oxygen species and the antioxidant system is preserved to maintain cellular redox homeostasis. Mitochondria play a key role in cellular function and cell survival. Mitochondria are vulnerable to damage that can be provoked by environmental exposures. Once the mitochondrial metabolism is damaged, it interferes with energy metabolism and eventually causes the overproduction of free radicals. Furthermore, it also perceives inflammation signals to generate an inflammatory response, which is involved in pathophysiological mechanisms. A depleted antioxidant system provokes oxidative stress that triggers inflammation and regulates epigenetic function and apoptotic events. Apart from that, these chemicals influence steroidogenesis, deteriorate sperm quality, and damage male reproductive organs. It is strongly believed that redox signaling molecules are the key regulators that mediate reproductive toxicity. This review article aims to spotlight the redox toxicology of environmental chemicals on male reproduction function and its fertility prognosis. Furthermore, we shed light on the influence of redox signaling and metabolism in modulating the response of environmental toxins to reproductive function. Additionally, we emphasize the supporting evidence from diverse cellular and animal studies. |
| first_indexed | 2024-03-07T21:42:10Z |
| format | Article |
| id | doaj.art-0f81d724d66646da86c5f5fa0f1cf98a |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-07T21:42:10Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-0f81d724d66646da86c5f5fa0f1cf98a2024-02-26T04:52:00ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2024-02-011210.3389/fcell.2024.13338451333845Redox mechanisms of environmental toxicants on male reproductive functionTarique Hussain0Tarique Hussain1Elsayed Metwally2Ghulam Murtaza3Dildar Hussain Kalhoro4Muhammad Ismail Chughtai5Bie Tan6Ali Dogan Omur7Shakeel Ahmed Tunio8Muhammad Shahzad Akbar9Muhammad Saleem Kalhoro10College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan, ChinaAnimal Science Division, Nuclear Institute for Agriculture and Biology College, Pakistan Institute of Engineering and Applied Sciences (NIAB-C, PIEAS), Faisalabad, PakistanDepartment of Cytology and Histology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, EgyptDepartment of Livestock and Fisheries, Government of Sindh, Karachi, PakistanDepartment of Veterinary Microbiology, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Sindh, PakistanAnimal Science Division, Nuclear Institute for Agriculture and Biology College, Pakistan Institute of Engineering and Applied Sciences (NIAB-C, PIEAS), Faisalabad, PakistanCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan, ChinaDepartment of Artificial Insemination, Faculty, Veterinary Medicine, Ataturk University, Erzurum, TürkiyeDepartment of Livestock Management, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Sindh, PakistanFaculty of Animal Husbandry and Veterinary Sciences, University of Poonch, Rawalakot, PakistanDepartment of Agro-Industrial, Food, and Environmental Technology, Faculty of Applied Science, Food and Agro-Industrial Research Centre, King Mongkut’s University of Technology North Bangkok, Bangkok, ThailandHumans and wildlife, including domesticated animals, are exposed to a myriad of environmental contaminants that are derived from various human activities, including agricultural, household, cosmetic, pharmaceutical, and industrial products. Excessive exposure to pesticides, heavy metals, and phthalates consequently causes the overproduction of reactive oxygen species. The equilibrium between reactive oxygen species and the antioxidant system is preserved to maintain cellular redox homeostasis. Mitochondria play a key role in cellular function and cell survival. Mitochondria are vulnerable to damage that can be provoked by environmental exposures. Once the mitochondrial metabolism is damaged, it interferes with energy metabolism and eventually causes the overproduction of free radicals. Furthermore, it also perceives inflammation signals to generate an inflammatory response, which is involved in pathophysiological mechanisms. A depleted antioxidant system provokes oxidative stress that triggers inflammation and regulates epigenetic function and apoptotic events. Apart from that, these chemicals influence steroidogenesis, deteriorate sperm quality, and damage male reproductive organs. It is strongly believed that redox signaling molecules are the key regulators that mediate reproductive toxicity. This review article aims to spotlight the redox toxicology of environmental chemicals on male reproduction function and its fertility prognosis. Furthermore, we shed light on the influence of redox signaling and metabolism in modulating the response of environmental toxins to reproductive function. Additionally, we emphasize the supporting evidence from diverse cellular and animal studies.https://www.frontiersin.org/articles/10.3389/fcell.2024.1333845/fullenvironmental toxicantsmale reproductionsperm quality and reactive oxygen speciesendocrine disruptorsredox mechanisms |
| spellingShingle | Tarique Hussain Tarique Hussain Elsayed Metwally Ghulam Murtaza Dildar Hussain Kalhoro Muhammad Ismail Chughtai Bie Tan Ali Dogan Omur Shakeel Ahmed Tunio Muhammad Shahzad Akbar Muhammad Saleem Kalhoro Redox mechanisms of environmental toxicants on male reproductive function Frontiers in Cell and Developmental Biology environmental toxicants male reproduction sperm quality and reactive oxygen species endocrine disruptors redox mechanisms |
| title | Redox mechanisms of environmental toxicants on male reproductive function |
| title_full | Redox mechanisms of environmental toxicants on male reproductive function |
| title_fullStr | Redox mechanisms of environmental toxicants on male reproductive function |
| title_full_unstemmed | Redox mechanisms of environmental toxicants on male reproductive function |
| title_short | Redox mechanisms of environmental toxicants on male reproductive function |
| title_sort | redox mechanisms of environmental toxicants on male reproductive function |
| topic | environmental toxicants male reproduction sperm quality and reactive oxygen species endocrine disruptors redox mechanisms |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1333845/full |
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