Sequential assessment of clinical and laboratory parameters in patients with hemorrhagic fever with renal syndrome.
BACKGROUND:Information on the sequential appearance, duration, and magnitude of clinical and laboratory parameters in hemorrhagic fever with renal syndrome (HFRS) is limited. METHODS:Analysis of clinical and laboratory parameters obtained serially in 81 patients with HFRS, of whom 15 were infected w...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5965875?pdf=render |
| _version_ | 1818597137852661760 |
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| author | Emil Pal Miša Korva Katarina Resman Rus Nataša Kejžar Petra Bogovič Anica Kurent Tatjana Avšič-Županc Franc Strle |
| author_facet | Emil Pal Miša Korva Katarina Resman Rus Nataša Kejžar Petra Bogovič Anica Kurent Tatjana Avšič-Županc Franc Strle |
| author_sort | Emil Pal |
| collection | DOAJ |
| description | BACKGROUND:Information on the sequential appearance, duration, and magnitude of clinical and laboratory parameters in hemorrhagic fever with renal syndrome (HFRS) is limited. METHODS:Analysis of clinical and laboratory parameters obtained serially in 81 patients with HFRS, of whom 15 were infected with Dobrava virus and 66 with Puumala virus. RESULTS:The initial signs/symptoms, appearing on median day 1 of illness, were fever, headache, and myalgia. These were present in 86%, 65%, and 40% of patients and had a median duration of 4, 4, and 5.5 days, respectively. The signs/symptoms were followed by myopia (appearance on day 5), insomnia (day 6), oliguria/anuria (day 6), polyuria (day 9), and sinus bradycardia (day 9.5). These were present in 35%, 30%, 28%, 91%, and 35% of patients; their median duration was 2, 2, 2, 7, and 1 day, respectively. Laboratory abnormalities, including thrombocytopenia, elevated alanine aminotransferase, CRP, procalcitonin, creatinine, diminished glomerular filtration rate, and leukocytosis, were ascertained on admission to hospital or on the following day (day 5 or 6 of illness) and were established in 95%, 87%, 99%, 91%, 94%, 87%, and 55% of patients, and had a median duration of 4, 3, 7, 3, 9, 8, and 2 days, respectively. Comparison of patients infected with Dobrava and Puumala viruses found several differences in the frequency, magnitude, and duration of abnormalities, indicating that Dobrava virus causes the more severe HFRS. CONCLUSIONS:In the majority of patients, the classic clinical distinction into febrile, hypotonic, oliguric, polyuric, and convalescent phases of illness is unclear. |
| first_indexed | 2024-12-16T11:43:02Z |
| format | Article |
| id | doaj.art-0f837b56542648ccbba37996707fe411 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T11:43:02Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0f837b56542648ccbba37996707fe4112022-12-21T22:32:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01135e019766110.1371/journal.pone.0197661Sequential assessment of clinical and laboratory parameters in patients with hemorrhagic fever with renal syndrome.Emil PalMiša KorvaKatarina Resman RusNataša KejžarPetra BogovičAnica KurentTatjana Avšič-ŽupancFranc StrleBACKGROUND:Information on the sequential appearance, duration, and magnitude of clinical and laboratory parameters in hemorrhagic fever with renal syndrome (HFRS) is limited. METHODS:Analysis of clinical and laboratory parameters obtained serially in 81 patients with HFRS, of whom 15 were infected with Dobrava virus and 66 with Puumala virus. RESULTS:The initial signs/symptoms, appearing on median day 1 of illness, were fever, headache, and myalgia. These were present in 86%, 65%, and 40% of patients and had a median duration of 4, 4, and 5.5 days, respectively. The signs/symptoms were followed by myopia (appearance on day 5), insomnia (day 6), oliguria/anuria (day 6), polyuria (day 9), and sinus bradycardia (day 9.5). These were present in 35%, 30%, 28%, 91%, and 35% of patients; their median duration was 2, 2, 2, 7, and 1 day, respectively. Laboratory abnormalities, including thrombocytopenia, elevated alanine aminotransferase, CRP, procalcitonin, creatinine, diminished glomerular filtration rate, and leukocytosis, were ascertained on admission to hospital or on the following day (day 5 or 6 of illness) and were established in 95%, 87%, 99%, 91%, 94%, 87%, and 55% of patients, and had a median duration of 4, 3, 7, 3, 9, 8, and 2 days, respectively. Comparison of patients infected with Dobrava and Puumala viruses found several differences in the frequency, magnitude, and duration of abnormalities, indicating that Dobrava virus causes the more severe HFRS. CONCLUSIONS:In the majority of patients, the classic clinical distinction into febrile, hypotonic, oliguric, polyuric, and convalescent phases of illness is unclear.http://europepmc.org/articles/PMC5965875?pdf=render |
| spellingShingle | Emil Pal Miša Korva Katarina Resman Rus Nataša Kejžar Petra Bogovič Anica Kurent Tatjana Avšič-Županc Franc Strle Sequential assessment of clinical and laboratory parameters in patients with hemorrhagic fever with renal syndrome. PLoS ONE |
| title | Sequential assessment of clinical and laboratory parameters in patients with hemorrhagic fever with renal syndrome. |
| title_full | Sequential assessment of clinical and laboratory parameters in patients with hemorrhagic fever with renal syndrome. |
| title_fullStr | Sequential assessment of clinical and laboratory parameters in patients with hemorrhagic fever with renal syndrome. |
| title_full_unstemmed | Sequential assessment of clinical and laboratory parameters in patients with hemorrhagic fever with renal syndrome. |
| title_short | Sequential assessment of clinical and laboratory parameters in patients with hemorrhagic fever with renal syndrome. |
| title_sort | sequential assessment of clinical and laboratory parameters in patients with hemorrhagic fever with renal syndrome |
| url | http://europepmc.org/articles/PMC5965875?pdf=render |
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