Plasmid-Mediated Transfer of Antibiotic Resistance Genes in Soil
Due to selective pressure from the widespread use of antibiotics, antibiotic resistance genes (ARGs) are found in human hosts, plants, and animals and virtually all natural environments. Their migration and transmission in different environmental media are often more harmful than antibiotics themsel...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-04-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/11/4/525 |
| _version_ | 1827621893356650496 |
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| author | Miaoling Meng Yaying Li Huaiying Yao |
| author_facet | Miaoling Meng Yaying Li Huaiying Yao |
| author_sort | Miaoling Meng |
| collection | DOAJ |
| description | Due to selective pressure from the widespread use of antibiotics, antibiotic resistance genes (ARGs) are found in human hosts, plants, and animals and virtually all natural environments. Their migration and transmission in different environmental media are often more harmful than antibiotics themselves. ARGs mainly move between different microorganisms through a variety of mobile genetic elements (MGEs), such as plasmids and phages. The soil environment is regarded as the most microbially active biosphere on the Earth’s surface and is closely related to human activities. With the increase in human activity, soils are becoming increasingly contaminated with antibiotics and ARGs. Soil plasmids play an important role in this process. This paper reviews the current scenario of plasmid-mediated migration and transmission of ARGs in natural environments and under different antibiotic selection pressures, summarizes the current methods of plasmid extraction and analysis, and briefly introduces the mechanism of plasmid splice transfer using the F factor as an example. However, as the global spread of drug-resistant bacteria has increased and the knowledge of MGEs improves, the contribution of soil plasmids to resistance gene transmission needs to be further investigated. The prevalence of multidrug-resistant bacteria has also made the effective prevention of the transmission of resistance genes through the plasmid-bacteria pathway a major research priority. |
| first_indexed | 2024-03-09T11:14:35Z |
| format | Article |
| id | doaj.art-0f84ba6bfdbc4dff833dd51f519a1db4 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T11:14:35Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-0f84ba6bfdbc4dff833dd51f519a1db42023-12-01T00:33:23ZengMDPI AGAntibiotics2079-63822022-04-0111452510.3390/antibiotics11040525Plasmid-Mediated Transfer of Antibiotic Resistance Genes in SoilMiaoling Meng0Yaying Li1Huaiying Yao2Research Center for Environmental Ecology and Engineering, School of Environmental Ecology and Biological Engineering, Wuhan Institute of Technology, Wuhan 430073, ChinaKey Laboratory of Urban Environment and Health, Ningbo Observation and Research Station, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, ChinaResearch Center for Environmental Ecology and Engineering, School of Environmental Ecology and Biological Engineering, Wuhan Institute of Technology, Wuhan 430073, ChinaDue to selective pressure from the widespread use of antibiotics, antibiotic resistance genes (ARGs) are found in human hosts, plants, and animals and virtually all natural environments. Their migration and transmission in different environmental media are often more harmful than antibiotics themselves. ARGs mainly move between different microorganisms through a variety of mobile genetic elements (MGEs), such as plasmids and phages. The soil environment is regarded as the most microbially active biosphere on the Earth’s surface and is closely related to human activities. With the increase in human activity, soils are becoming increasingly contaminated with antibiotics and ARGs. Soil plasmids play an important role in this process. This paper reviews the current scenario of plasmid-mediated migration and transmission of ARGs in natural environments and under different antibiotic selection pressures, summarizes the current methods of plasmid extraction and analysis, and briefly introduces the mechanism of plasmid splice transfer using the F factor as an example. However, as the global spread of drug-resistant bacteria has increased and the knowledge of MGEs improves, the contribution of soil plasmids to resistance gene transmission needs to be further investigated. The prevalence of multidrug-resistant bacteria has also made the effective prevention of the transmission of resistance genes through the plasmid-bacteria pathway a major research priority.https://www.mdpi.com/2079-6382/11/4/525plasmidantibiotic resistance genesgene transfersoil |
| spellingShingle | Miaoling Meng Yaying Li Huaiying Yao Plasmid-Mediated Transfer of Antibiotic Resistance Genes in Soil Antibiotics plasmid antibiotic resistance genes gene transfer soil |
| title | Plasmid-Mediated Transfer of Antibiotic Resistance Genes in Soil |
| title_full | Plasmid-Mediated Transfer of Antibiotic Resistance Genes in Soil |
| title_fullStr | Plasmid-Mediated Transfer of Antibiotic Resistance Genes in Soil |
| title_full_unstemmed | Plasmid-Mediated Transfer of Antibiotic Resistance Genes in Soil |
| title_short | Plasmid-Mediated Transfer of Antibiotic Resistance Genes in Soil |
| title_sort | plasmid mediated transfer of antibiotic resistance genes in soil |
| topic | plasmid antibiotic resistance genes gene transfer soil |
| url | https://www.mdpi.com/2079-6382/11/4/525 |
| work_keys_str_mv | AT miaolingmeng plasmidmediatedtransferofantibioticresistancegenesinsoil AT yayingli plasmidmediatedtransferofantibioticresistancegenesinsoil AT huaiyingyao plasmidmediatedtransferofantibioticresistancegenesinsoil |