REACTIVITY OF BLOOD LYMPHOCYTES IN PULMONARY TUBERCULOSIS
Evaluation of proliferative and IL-2-producing activity of peripheral blood lymphocytes wasperformed, using cultural methods, in patients with drug-sensitive and drug-resistant infiltrative pulmonary tuberculosis. The cell testing was performed at basal level and following in vitro stimulation with...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/73 |
| _version_ | 1797198138908344320 |
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| author | R. R. Khasanova O. V. Voronkova O. I. Urazova V. V. Novitsky A. K. Strelis Yu. V. Stambula A. E. Kolosova V. A. Serebryakova I. O. Naslednikova O. V. Kolokolova T. E. Budkina N. P. Pirogova |
| author_facet | R. R. Khasanova O. V. Voronkova O. I. Urazova V. V. Novitsky A. K. Strelis Yu. V. Stambula A. E. Kolosova V. A. Serebryakova I. O. Naslednikova O. V. Kolokolova T. E. Budkina N. P. Pirogova |
| author_sort | R. R. Khasanova |
| collection | DOAJ |
| description | Evaluation of proliferative and IL-2-producing activity of peripheral blood lymphocytes wasperformed, using cultural methods, in patients with drug-sensitive and drug-resistant infiltrative pulmonary tuberculosis. The cell testing was performed at basal level and following in vitro stimulation with recombinant IL-2 and M. tuberculosis antigens. It was established that clinical course of infiltrative pulmonary tuberculosis, independently on drug sensitivity/resistance of the infectious pathogen, is accompanied by suppression of spontaneous lymphoproliferation. The levels of induced IL-2 production in drug-sensitive tuberculosis proved to be increased, whereas a reserve of IL-2-secreting reactivity of blood lymphocytes was lower than in drugresistant infection. Also, it was revealed that the level of lymphoproliferative response induced by IL-2, does not depend on clinical variant of tuberculosis, whereas stimulation of IL-2 production in blood lymphocytes is attained only in cases of drug-resistant tuberculosis variant. |
| first_indexed | 2024-03-08T05:52:18Z |
| format | Article |
| id | doaj.art-0f8520d5db3c4da18da6c2fc7d86cdae |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:55:06Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-0f8520d5db3c4da18da6c2fc7d86cdae2024-04-22T13:07:32ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01111354010.15789/1563-0625-2009-1-35-4071REACTIVITY OF BLOOD LYMPHOCYTES IN PULMONARY TUBERCULOSISR. R. Khasanova0O. V. Voronkova1O. I. Urazova2V. V. Novitsky3A. K. Strelis4Yu. V. Stambula5A. E. Kolosova6V. A. Serebryakova7I. O. Naslednikova8O. V. Kolokolova9T. E. Budkina10N. P. Pirogova11ГОУ ВПО «Сибирский государственный медицинский университет», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет», г. ТомскEvaluation of proliferative and IL-2-producing activity of peripheral blood lymphocytes wasperformed, using cultural methods, in patients with drug-sensitive and drug-resistant infiltrative pulmonary tuberculosis. The cell testing was performed at basal level and following in vitro stimulation with recombinant IL-2 and M. tuberculosis antigens. It was established that clinical course of infiltrative pulmonary tuberculosis, independently on drug sensitivity/resistance of the infectious pathogen, is accompanied by suppression of spontaneous lymphoproliferation. The levels of induced IL-2 production in drug-sensitive tuberculosis proved to be increased, whereas a reserve of IL-2-secreting reactivity of blood lymphocytes was lower than in drugresistant infection. Also, it was revealed that the level of lymphoproliferative response induced by IL-2, does not depend on clinical variant of tuberculosis, whereas stimulation of IL-2 production in blood lymphocytes is attained only in cases of drug-resistant tuberculosis variant.https://www.mimmun.ru/mimmun/article/view/73pumonary tuberculosisantigenslymphocytescytokinesreactivity |
| spellingShingle | R. R. Khasanova O. V. Voronkova O. I. Urazova V. V. Novitsky A. K. Strelis Yu. V. Stambula A. E. Kolosova V. A. Serebryakova I. O. Naslednikova O. V. Kolokolova T. E. Budkina N. P. Pirogova REACTIVITY OF BLOOD LYMPHOCYTES IN PULMONARY TUBERCULOSIS Медицинская иммунология pumonary tuberculosis antigens lymphocytes cytokines reactivity |
| title | REACTIVITY OF BLOOD LYMPHOCYTES IN PULMONARY TUBERCULOSIS |
| title_full | REACTIVITY OF BLOOD LYMPHOCYTES IN PULMONARY TUBERCULOSIS |
| title_fullStr | REACTIVITY OF BLOOD LYMPHOCYTES IN PULMONARY TUBERCULOSIS |
| title_full_unstemmed | REACTIVITY OF BLOOD LYMPHOCYTES IN PULMONARY TUBERCULOSIS |
| title_short | REACTIVITY OF BLOOD LYMPHOCYTES IN PULMONARY TUBERCULOSIS |
| title_sort | reactivity of blood lymphocytes in pulmonary tuberculosis |
| topic | pumonary tuberculosis antigens lymphocytes cytokines reactivity |
| url | https://www.mimmun.ru/mimmun/article/view/73 |
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