Recent advances in treating Parkinson’s disease [version 1; referees: 2 approved]
This article summarizes (1) the recent achievements to further improve symptomatic therapy of motor Parkinson’s disease (PD) symptoms, (2) the still-few attempts to systematically search for symptomatic therapy of non-motor symptoms in PD, and (3) the advances in the development and clinical testing...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2017-03-01
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| Series: | F1000Research |
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| Online Access: | https://f1000research.com/articles/6-260/v1 |
| _version_ | 1818334586063552512 |
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| author | Wolfgang H. Oertel |
| author_facet | Wolfgang H. Oertel |
| author_sort | Wolfgang H. Oertel |
| collection | DOAJ |
| description | This article summarizes (1) the recent achievements to further improve symptomatic therapy of motor Parkinson’s disease (PD) symptoms, (2) the still-few attempts to systematically search for symptomatic therapy of non-motor symptoms in PD, and (3) the advances in the development and clinical testing of compounds which promise to offer disease modification in already-manifest PD. However, prevention (that is, slowing or stopping PD in a prodromal stage) is still a dream and one reason for this is that we have no consensus on primary endpoints for clinical trials which reflect the progression in prodromal stages of PD, such as in rapid eye movement sleep behavior disorder (RBD) —a methodological challenge to be met in the future. |
| first_indexed | 2024-12-13T14:09:53Z |
| format | Article |
| id | doaj.art-0f854d51046b4fb4bc35fba2825f15d5 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-13T14:09:53Z |
| publishDate | 2017-03-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-0f854d51046b4fb4bc35fba2825f15d52022-12-21T23:42:29ZengF1000 Research LtdF1000Research2046-14022017-03-01610.12688/f1000research.10100.110881Recent advances in treating Parkinson’s disease [version 1; referees: 2 approved]Wolfgang H. Oertel0Institute for Neurogenomics, Helmholtz Center for Health and Environment, Munich, GermanyThis article summarizes (1) the recent achievements to further improve symptomatic therapy of motor Parkinson’s disease (PD) symptoms, (2) the still-few attempts to systematically search for symptomatic therapy of non-motor symptoms in PD, and (3) the advances in the development and clinical testing of compounds which promise to offer disease modification in already-manifest PD. However, prevention (that is, slowing or stopping PD in a prodromal stage) is still a dream and one reason for this is that we have no consensus on primary endpoints for clinical trials which reflect the progression in prodromal stages of PD, such as in rapid eye movement sleep behavior disorder (RBD) —a methodological challenge to be met in the future.https://f1000research.com/articles/6-260/v1Movement DisordersNeurobiology of Disease & RegenerationNeuronal Signaling MechanismsNeuropharmacology & Psychopharmacology |
| spellingShingle | Wolfgang H. Oertel Recent advances in treating Parkinson’s disease [version 1; referees: 2 approved] F1000Research Movement Disorders Neurobiology of Disease & Regeneration Neuronal Signaling Mechanisms Neuropharmacology & Psychopharmacology |
| title | Recent advances in treating Parkinson’s disease [version 1; referees: 2 approved] |
| title_full | Recent advances in treating Parkinson’s disease [version 1; referees: 2 approved] |
| title_fullStr | Recent advances in treating Parkinson’s disease [version 1; referees: 2 approved] |
| title_full_unstemmed | Recent advances in treating Parkinson’s disease [version 1; referees: 2 approved] |
| title_short | Recent advances in treating Parkinson’s disease [version 1; referees: 2 approved] |
| title_sort | recent advances in treating parkinson s disease version 1 referees 2 approved |
| topic | Movement Disorders Neurobiology of Disease & Regeneration Neuronal Signaling Mechanisms Neuropharmacology & Psychopharmacology |
| url | https://f1000research.com/articles/6-260/v1 |
| work_keys_str_mv | AT wolfganghoertel recentadvancesintreatingparkinsonsdiseaseversion1referees2approved |