Remineralization potential of strontium-doped nano-hydroxyapatite dentifrice and casein phosphopeptide-amorphous calcium phosphate cream on white spot lesions in enamel following orthodontic debonding – a randomized controlled trial
Aim and Objective: This study was intended to compare and determine the potency of strontium-doped nano-hydroxyapatite paste against a topical cream containing casein phosphopeptide-amorphous calcium phosphate and a regular dentifrice for remineralization of white spot lesions of enamel following or...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-01-01
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| Series: | SAGE Open Medicine |
| Online Access: | https://doi.org/10.1177/20503121231221634 |
| _version_ | 1797371882192764928 |
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| author | Ratheesh Rajendran Delphine Priscilla Antony S Mohammed Ashik P Subin Bharath Arun Jacob Thomas Artak Heboyan |
| author_facet | Ratheesh Rajendran Delphine Priscilla Antony S Mohammed Ashik P Subin Bharath Arun Jacob Thomas Artak Heboyan |
| author_sort | Ratheesh Rajendran |
| collection | DOAJ |
| description | Aim and Objective: This study was intended to compare and determine the potency of strontium-doped nano-hydroxyapatite paste against a topical cream containing casein phosphopeptide-amorphous calcium phosphate and a regular dentifrice for remineralization of white spot lesions of enamel following orthodontic debonding. Methods: Ninety individuals with white spot lesions on their enamel who visited the orthodontic department for de-bonding were selected for the research. Patients were randomly assigned to three distinct groups with each group consisting of 30 patients. Group 1 served as the control and received regular dentifrice, Group 2 received strontium-doped nano-hydroxyapatite paste, and Group 3 received casein phosphopeptide-amorphous calcium phosphate topical cream. Patients were instructed to locally apply a specified amount of the prescribed preparation twice daily for six weeks. The data were analysed using the statistical programme SPSS 22.0 (SPSS Inc., Chicago, IL, USA), and the level of significance had been set at p < 0.05. Results: Group 1 did not show any change in the enamel following the application of toothpaste. Both Group 2 and 3 demonstrated higher post-treatment scores, indicating effective remineralization potential ( p < 0.001). However, Group 2 (strontium-doped nano-hydroxyapatite paste) displayed significantly greater remineralization capacity when compared to group 3 (casein phosphopeptide-amorphous calcium phosphate topical cream). Conclusion: Compared to conventional dentifrice and casein phosphopeptide-amorphous calcium phosphate paste, strontium-doped nano-hydroxyapatite preparation demonstrated greater enamel remineralization of the white spot lesions and favourable surface alterations in the enamel surface. strontium-doped nano-hydroxyapatite can be utilised safely and efficiently to treat early caries and remineralise white spot lesions on the enamel. |
| first_indexed | 2024-03-08T18:27:21Z |
| format | Article |
| id | doaj.art-0f85840814f34f16acd2f478a10a1745 |
| institution | Directory Open Access Journal |
| issn | 2050-3121 |
| language | English |
| last_indexed | 2024-03-08T18:27:21Z |
| publishDate | 2024-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medicine |
| spelling | doaj.art-0f85840814f34f16acd2f478a10a17452023-12-30T09:03:45ZengSAGE PublishingSAGE Open Medicine2050-31212024-01-011210.1177/20503121231221634Remineralization potential of strontium-doped nano-hydroxyapatite dentifrice and casein phosphopeptide-amorphous calcium phosphate cream on white spot lesions in enamel following orthodontic debonding – a randomized controlled trialRatheesh Rajendran0Delphine Priscilla Antony S1Mohammed Ashik P2Subin Bharath3Arun Jacob Thomas4Artak Heboyan5Department of Conservative Dentistry and Endodontics, Saveetha Dental college and hospitals, Saveetha institute of medical and technical sciences, Saveetha University, Chennai-77, TN, IndiaDepartment of Conservative Dentistry and Endodontics, Saveetha Dental college and hospitals, Saveetha institute of medical and technical sciences, Saveetha University, Chennai-77, TN, IndiaKMCT Dental College, Kozhikode, KL, IndiaKMCT Dental College, Kozhikode, KL, IndiaNoorul Islam College of Dental Science, Thiruvananthapuram, KL, IndiaDepartment of Prosthodontics, Faculty of Stomatology, Yerevan State Medical University Named after Mkhitar Heratsi, Yerevan, ArmeniaAim and Objective: This study was intended to compare and determine the potency of strontium-doped nano-hydroxyapatite paste against a topical cream containing casein phosphopeptide-amorphous calcium phosphate and a regular dentifrice for remineralization of white spot lesions of enamel following orthodontic debonding. Methods: Ninety individuals with white spot lesions on their enamel who visited the orthodontic department for de-bonding were selected for the research. Patients were randomly assigned to three distinct groups with each group consisting of 30 patients. Group 1 served as the control and received regular dentifrice, Group 2 received strontium-doped nano-hydroxyapatite paste, and Group 3 received casein phosphopeptide-amorphous calcium phosphate topical cream. Patients were instructed to locally apply a specified amount of the prescribed preparation twice daily for six weeks. The data were analysed using the statistical programme SPSS 22.0 (SPSS Inc., Chicago, IL, USA), and the level of significance had been set at p < 0.05. Results: Group 1 did not show any change in the enamel following the application of toothpaste. Both Group 2 and 3 demonstrated higher post-treatment scores, indicating effective remineralization potential ( p < 0.001). However, Group 2 (strontium-doped nano-hydroxyapatite paste) displayed significantly greater remineralization capacity when compared to group 3 (casein phosphopeptide-amorphous calcium phosphate topical cream). Conclusion: Compared to conventional dentifrice and casein phosphopeptide-amorphous calcium phosphate paste, strontium-doped nano-hydroxyapatite preparation demonstrated greater enamel remineralization of the white spot lesions and favourable surface alterations in the enamel surface. strontium-doped nano-hydroxyapatite can be utilised safely and efficiently to treat early caries and remineralise white spot lesions on the enamel.https://doi.org/10.1177/20503121231221634 |
| spellingShingle | Ratheesh Rajendran Delphine Priscilla Antony S Mohammed Ashik P Subin Bharath Arun Jacob Thomas Artak Heboyan Remineralization potential of strontium-doped nano-hydroxyapatite dentifrice and casein phosphopeptide-amorphous calcium phosphate cream on white spot lesions in enamel following orthodontic debonding – a randomized controlled trial SAGE Open Medicine |
| title | Remineralization potential of strontium-doped nano-hydroxyapatite dentifrice and casein phosphopeptide-amorphous calcium phosphate cream on white spot lesions in enamel following orthodontic debonding – a randomized controlled trial |
| title_full | Remineralization potential of strontium-doped nano-hydroxyapatite dentifrice and casein phosphopeptide-amorphous calcium phosphate cream on white spot lesions in enamel following orthodontic debonding – a randomized controlled trial |
| title_fullStr | Remineralization potential of strontium-doped nano-hydroxyapatite dentifrice and casein phosphopeptide-amorphous calcium phosphate cream on white spot lesions in enamel following orthodontic debonding – a randomized controlled trial |
| title_full_unstemmed | Remineralization potential of strontium-doped nano-hydroxyapatite dentifrice and casein phosphopeptide-amorphous calcium phosphate cream on white spot lesions in enamel following orthodontic debonding – a randomized controlled trial |
| title_short | Remineralization potential of strontium-doped nano-hydroxyapatite dentifrice and casein phosphopeptide-amorphous calcium phosphate cream on white spot lesions in enamel following orthodontic debonding – a randomized controlled trial |
| title_sort | remineralization potential of strontium doped nano hydroxyapatite dentifrice and casein phosphopeptide amorphous calcium phosphate cream on white spot lesions in enamel following orthodontic debonding a randomized controlled trial |
| url | https://doi.org/10.1177/20503121231221634 |
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