T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles
Glioblastoma is a highly aggressive, and also the most common, brain tumour type in adults. Here, the authors generate a nanoparticle encapsulating the TLR7/8 agonist, R848, which induces tumour regression in mice by reprogramming myeloid cells independently of T and NK cells.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36321-6 |
| _version_ | 1811165815618142208 |
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| author | Verena Turco Kira Pfleiderer Jessica Hunger Natalie K. Horvat Kianush Karimian-Jazi Katharina Schregel Manuel Fischer Gianluca Brugnara Kristine Jähne Volker Sturm Yannik Streibel Duy Nguyen Sandro Altamura Dennis A. Agardy Shreya S. Soni Abdulrahman Alsasa Theresa Bunse Matthias Schlesner Martina U. Muckenthaler Ralph Weissleder Wolfgang Wick Sabine Heiland Philipp Vollmuth Martin Bendszus Christopher B. Rodell Michael O. Breckwoldt Michael Platten |
| author_facet | Verena Turco Kira Pfleiderer Jessica Hunger Natalie K. Horvat Kianush Karimian-Jazi Katharina Schregel Manuel Fischer Gianluca Brugnara Kristine Jähne Volker Sturm Yannik Streibel Duy Nguyen Sandro Altamura Dennis A. Agardy Shreya S. Soni Abdulrahman Alsasa Theresa Bunse Matthias Schlesner Martina U. Muckenthaler Ralph Weissleder Wolfgang Wick Sabine Heiland Philipp Vollmuth Martin Bendszus Christopher B. Rodell Michael O. Breckwoldt Michael Platten |
| author_sort | Verena Turco |
| collection | DOAJ |
| description | Glioblastoma is a highly aggressive, and also the most common, brain tumour type in adults. Here, the authors generate a nanoparticle encapsulating the TLR7/8 agonist, R848, which induces tumour regression in mice by reprogramming myeloid cells independently of T and NK cells. |
| first_indexed | 2024-04-10T15:42:57Z |
| format | Article |
| id | doaj.art-0f85af58c6e64df3af7a9ef3d9fc543c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T15:42:57Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0f85af58c6e64df3af7a9ef3d9fc543c2023-02-12T12:16:01ZengNature PortfolioNature Communications2041-17232023-02-0114111510.1038/s41467-023-36321-6T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticlesVerena Turco0Kira Pfleiderer1Jessica Hunger2Natalie K. Horvat3Kianush Karimian-Jazi4Katharina Schregel5Manuel Fischer6Gianluca Brugnara7Kristine Jähne8Volker Sturm9Yannik Streibel10Duy Nguyen11Sandro Altamura12Dennis A. Agardy13Shreya S. Soni14Abdulrahman Alsasa15Theresa Bunse16Matthias Schlesner17Martina U. Muckenthaler18Ralph Weissleder19Wolfgang Wick20Sabine Heiland21Philipp Vollmuth22Martin Bendszus23Christopher B. Rodell24Michael O. Breckwoldt25Michael Platten26Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Consortium (DKTK) within the German Cancer Research Center (DKFZ)Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Consortium (DKTK) within the German Cancer Research Center (DKFZ)Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Consortium (DKTK) within the German Cancer Research Center (DKFZ)Faculty of Biosciences, Heidelberg UniversityNeuroradiology Department, University Hospital HeidelbergNeuroradiology Department, University Hospital HeidelbergNeuroradiology Department, University Hospital HeidelbergNeuroradiology Department, University Hospital HeidelbergClinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Consortium (DKTK) within the German Cancer Research Center (DKFZ)Neuroradiology Department, University Hospital HeidelbergNeuroradiology Department, University Hospital HeidelbergJunior Research Group Bioinformatics and Omics Data Analytics, DKFZDepartment of Pediatric Oncology, Hematology and Immunology, University HospitalClinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Consortium (DKTK) within the German Cancer Research Center (DKFZ)School of Biomedical Engineering, Science and Health Systems, Drexel UniversitySchool of Biomedical Engineering, Science and Health Systems, Drexel UniversityClinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Consortium (DKTK) within the German Cancer Research Center (DKFZ)Junior Research Group Bioinformatics and Omics Data Analytics, DKFZDepartment of Pediatric Oncology, Hematology and Immunology, University HospitalCenter for Systems Biology, Massachusetts General HospitalClinical Cooperation Unit Neurooncology, DKTK within DKFZNeuroradiology Department, University Hospital HeidelbergNeuroradiology Department, University Hospital HeidelbergNeuroradiology Department, University Hospital HeidelbergSchool of Biomedical Engineering, Science and Health Systems, Drexel UniversityClinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Consortium (DKTK) within the German Cancer Research Center (DKFZ)Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Consortium (DKTK) within the German Cancer Research Center (DKFZ)Glioblastoma is a highly aggressive, and also the most common, brain tumour type in adults. Here, the authors generate a nanoparticle encapsulating the TLR7/8 agonist, R848, which induces tumour regression in mice by reprogramming myeloid cells independently of T and NK cells.https://doi.org/10.1038/s41467-023-36321-6 |
| spellingShingle | Verena Turco Kira Pfleiderer Jessica Hunger Natalie K. Horvat Kianush Karimian-Jazi Katharina Schregel Manuel Fischer Gianluca Brugnara Kristine Jähne Volker Sturm Yannik Streibel Duy Nguyen Sandro Altamura Dennis A. Agardy Shreya S. Soni Abdulrahman Alsasa Theresa Bunse Matthias Schlesner Martina U. Muckenthaler Ralph Weissleder Wolfgang Wick Sabine Heiland Philipp Vollmuth Martin Bendszus Christopher B. Rodell Michael O. Breckwoldt Michael Platten T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles Nature Communications |
| title | T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles |
| title_full | T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles |
| title_fullStr | T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles |
| title_full_unstemmed | T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles |
| title_short | T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles |
| title_sort | t cell independent eradication of experimental glioma by intravenous tlr7 8 agonist loaded nanoparticles |
| url | https://doi.org/10.1038/s41467-023-36321-6 |
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