HNF1A regulates colorectal cancer progression and drug resistance as a downstream of POU5F1

HNF1A regulates colorectal cancer progression and drug resistance as a downstream of POU5F1

Abstract POU5F1-expressing cells can self-renew and differentiate, contributing to metastasis formation in colorectal cancer (CRC), but it plays an important role in normal pluripotent stem cells. Here, we identified the CRC-specific gene, HNF1A, which is the downstream of POU5F1. HNF1A associates w...

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Bibliographic Details
Main Authors:	Shiki Fujino, Norikatsu Miyoshi, Aya Ito, Masayoshi Yasui, Chu Matsuda, Masayuki Ohue, Mamoru Uemura, Tsunekazu Mizushima, Yuichiro Doki, Hidetoshi Eguchi
Format:	Article
Language:	English
Published:	Nature Portfolio 2021-05-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-021-89126-2

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