Analysis of the Mortality Trends of 23 Major Cancers in the Indian Population Between 2000 and 2019: A Joinpoint Regression Analysis
PURPOSECancer mortality trends have not been documented across the population of India. We, therefore, analyzed the overall and individual cancer mortality trends for 23 major cancers between 2000 and 2019 on the basis of Global Health Observatory (GHO) database.MATERIALS AND METHODSThis study exami...
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| Format: | Article |
| Language: | English |
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American Society of Clinical Oncology
2023-03-01
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| Series: | JCO Global Oncology |
| Online Access: | https://ascopubs.org/doi/10.1200/GO.22.00405 |
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| author | Ajil Shaji Pavithran Keechilat Vijaykumar DK Catherine Sauvaget |
| author_facet | Ajil Shaji Pavithran Keechilat Vijaykumar DK Catherine Sauvaget |
| author_sort | Ajil Shaji |
| collection | DOAJ |
| description | PURPOSECancer mortality trends have not been documented across the population of India. We, therefore, analyzed the overall and individual cancer mortality trends for 23 major cancers between 2000 and 2019 on the basis of Global Health Observatory (GHO) database.MATERIALS AND METHODSThis study examined cancer mortality trends for 23 major cancer sites on the basis of 12.85 million cancer deaths obtained from the GHO of the WHO between 2000 and 2019. A joinpoint regression model was used to analyze the long-term trends of cancer mortality. Annual percentage change (APC) and average APC were estimated for various cancer sites.RESULTSBetween 2000 and 2019, 12.85 million deaths occurred in India from 23 major cancers. The most common lethal cancers were mouth and oropharyngeal (15.6%), stomach (10.6%), lung (9.6%), breast (9%), and colorectal (8%) cancers. The mortality trend decreased by 0.19% annually among men and increased nonsignificantly by 0.25% among women; an increase of 0.02% was observed among combined sexes. Increasing mortality trends were seen among cancers of the lung, breast, colorectum, lymphoma, multiple myeloma, gallbladder, pancreas, kidney, and mesothelioma between 2000 and 2019. The highest annual increase in mortality was observed in pancreatic cancer among both sexes: 2.7%, 2.1% among men, and 3.7% in women. The cancers of the stomach, esophagus, leukemia, larynx, and melanoma showed a declining cancer mortality trend irrespective of sex.CONCLUSIONA multifaceted strategy is required to tackle the rising cancer mortality rates in India; the best long-term strategy could be implementing awareness on cancer symptoms among the population as well as cancer prevention policies with improved health infrastructure and specifically dedicated human resources. |
| first_indexed | 2024-04-09T22:17:56Z |
| format | Article |
| id | doaj.art-0f85f6619a604c67b0680c55273d230a |
| institution | Directory Open Access Journal |
| issn | 2687-8941 |
| language | English |
| last_indexed | 2024-04-09T22:17:56Z |
| publishDate | 2023-03-01 |
| publisher | American Society of Clinical Oncology |
| record_format | Article |
| series | JCO Global Oncology |
| spelling | doaj.art-0f85f6619a604c67b0680c55273d230a2023-03-22T19:59:13ZengAmerican Society of Clinical OncologyJCO Global Oncology2687-89412023-03-01910.1200/GO.22.00405Analysis of the Mortality Trends of 23 Major Cancers in the Indian Population Between 2000 and 2019: A Joinpoint Regression AnalysisAjil Shaji0Pavithran Keechilat1Vijaykumar DK2Catherine Sauvaget3Amrita Institute of Medical Sciences, Amrita VishwaVidhyapeedham, Cochin, IndiaAmrita Institute of Medical Sciences, Amrita VishwaVidhyapeedham, Cochin, IndiaAmrita Institute of Medical Sciences, Amrita VishwaVidhyapeedham, Cochin, IndiaEarly Detection, Prevention and Infections Branch, International Agency for Research on Cancer, Lyon, FrancePURPOSECancer mortality trends have not been documented across the population of India. We, therefore, analyzed the overall and individual cancer mortality trends for 23 major cancers between 2000 and 2019 on the basis of Global Health Observatory (GHO) database.MATERIALS AND METHODSThis study examined cancer mortality trends for 23 major cancer sites on the basis of 12.85 million cancer deaths obtained from the GHO of the WHO between 2000 and 2019. A joinpoint regression model was used to analyze the long-term trends of cancer mortality. Annual percentage change (APC) and average APC were estimated for various cancer sites.RESULTSBetween 2000 and 2019, 12.85 million deaths occurred in India from 23 major cancers. The most common lethal cancers were mouth and oropharyngeal (15.6%), stomach (10.6%), lung (9.6%), breast (9%), and colorectal (8%) cancers. The mortality trend decreased by 0.19% annually among men and increased nonsignificantly by 0.25% among women; an increase of 0.02% was observed among combined sexes. Increasing mortality trends were seen among cancers of the lung, breast, colorectum, lymphoma, multiple myeloma, gallbladder, pancreas, kidney, and mesothelioma between 2000 and 2019. The highest annual increase in mortality was observed in pancreatic cancer among both sexes: 2.7%, 2.1% among men, and 3.7% in women. The cancers of the stomach, esophagus, leukemia, larynx, and melanoma showed a declining cancer mortality trend irrespective of sex.CONCLUSIONA multifaceted strategy is required to tackle the rising cancer mortality rates in India; the best long-term strategy could be implementing awareness on cancer symptoms among the population as well as cancer prevention policies with improved health infrastructure and specifically dedicated human resources.https://ascopubs.org/doi/10.1200/GO.22.00405 |
| spellingShingle | Ajil Shaji Pavithran Keechilat Vijaykumar DK Catherine Sauvaget Analysis of the Mortality Trends of 23 Major Cancers in the Indian Population Between 2000 and 2019: A Joinpoint Regression Analysis JCO Global Oncology |
| title | Analysis of the Mortality Trends of 23 Major Cancers in the Indian Population Between 2000 and 2019: A Joinpoint Regression Analysis |
| title_full | Analysis of the Mortality Trends of 23 Major Cancers in the Indian Population Between 2000 and 2019: A Joinpoint Regression Analysis |
| title_fullStr | Analysis of the Mortality Trends of 23 Major Cancers in the Indian Population Between 2000 and 2019: A Joinpoint Regression Analysis |
| title_full_unstemmed | Analysis of the Mortality Trends of 23 Major Cancers in the Indian Population Between 2000 and 2019: A Joinpoint Regression Analysis |
| title_short | Analysis of the Mortality Trends of 23 Major Cancers in the Indian Population Between 2000 and 2019: A Joinpoint Regression Analysis |
| title_sort | analysis of the mortality trends of 23 major cancers in the indian population between 2000 and 2019 a joinpoint regression analysis |
| url | https://ascopubs.org/doi/10.1200/GO.22.00405 |
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