Systematic evaluation of C. elegans lincRNAs with CRISPR knockout mutants

Systematic evaluation of C. elegans lincRNAs with CRISPR knockout mutants

Abstract Background Long intergenic RNAs (lincRNAs) play critical roles in eukaryotic cells, but systematic analyses of the lincRNAs of an animal for phenotypes are lacking. We generate CRISPR knockout strains for Caenorhabditis elegans lincRNAs and evaluate their phenotypes. Results C. elegans linc...

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Bibliographic Details
Main Authors: Shuai Wei, He Chen, Emmanuel Enoch Dzakah, Bin Yu, Xiaolin Wang, Tao Fu, Jingxin Li, Lei Liu, Shucheng Fang, Weihong Liu, Ge Shan
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Genome Biology
Subjects:
C. elegans
lincRNA
MicroRNA
CRISPR
Phenotype
Transcription factor
Online Access:http://link.springer.com/article/10.1186/s13059-018-1619-6

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