Effect of perioperative acupoint electrical stimulation on macrophages in mice under operative stress
Abstract The strong perioperative stress response caused by surgical anesthesia can significantly suppress immune function, and the body is in a state of immunosuppression for 3 to 4 days after surgery, which leads to an increase in the probability of postoperative infection. Traditional Chinese med...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Journal of Inflammation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12950-023-00354-x |
| _version_ | 1797453854545018880 |
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| author | Yinzhou Zhang Junying Wei Xinyuan Wu Mengting Jiang Wuhua Ma Yuhui Li |
| author_facet | Yinzhou Zhang Junying Wei Xinyuan Wu Mengting Jiang Wuhua Ma Yuhui Li |
| author_sort | Yinzhou Zhang |
| collection | DOAJ |
| description | Abstract The strong perioperative stress response caused by surgical anesthesia can significantly suppress immune function, and the body is in a state of immunosuppression for 3 to 4 days after surgery, which leads to an increase in the probability of postoperative infection. Traditional Chinese medicine believes that acupuncture points can "reconcile yin and yang", promote the recovery of immune function, and help reduce the incidence of postoperative infection. Macrophages are an important type of immune cells that participate in the body's innate immunity. They have powerful phagocytosis and clearance functions. They can be polarized into M1 and M2 types under the regulation of the body, and play different roles in fighting microbial infections. Among them, the M1 type can participate in the elimination of pathogens. In this study, we will investigate the perioperative acupoint electrical stimulation to alleviate the immunosuppressive state of surgical stress mice, clarify the regulation of perioperative acupoint electrical stimulation on glucocorticoids and the relationship between NF-κB molecules and macrophage polarization.The key molecules of related pathways were verified by glucocorticoid receptor inhibitors, and it was found that electrical stimulation of acupoints during the perioperative period can affect the polarization of macrophages in surgically stressed mice to the M1 type by reducing the level of glucocorticoids and promoting the expression of NF κB molecules. Further reveal the partial mechanism of electroacupuncture regulating the anti-inflammatory and pro-inflammatory processes of macrophages in the immune response. |
| first_indexed | 2024-03-09T15:28:53Z |
| format | Article |
| id | doaj.art-0f8889cba9af4e208f9a8e2ea89780b2 |
| institution | Directory Open Access Journal |
| issn | 1476-9255 |
| language | English |
| last_indexed | 2024-03-09T15:28:53Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Inflammation |
| spelling | doaj.art-0f8889cba9af4e208f9a8e2ea89780b22023-11-26T12:20:48ZengBMCJournal of Inflammation1476-92552023-08-0120111110.1186/s12950-023-00354-xEffect of perioperative acupoint electrical stimulation on macrophages in mice under operative stressYinzhou Zhang0Junying Wei1Xinyuan Wu2Mengting Jiang3Wuhua Ma4Yuhui Li5 Lingnan Medical Research Center, Guangzhou University of Chinese Medicine Lingnan Medical Research Center, Guangzhou University of Chinese MedicineThe First Affiliated Hospital of Guangzhou University of Chinese Medicine Lingnan Medical Research Center, Guangzhou University of Chinese MedicineThe First Affiliated Hospital of Guangzhou University of Chinese MedicineThe First Affiliated Hospital of Guangzhou University of Chinese MedicineAbstract The strong perioperative stress response caused by surgical anesthesia can significantly suppress immune function, and the body is in a state of immunosuppression for 3 to 4 days after surgery, which leads to an increase in the probability of postoperative infection. Traditional Chinese medicine believes that acupuncture points can "reconcile yin and yang", promote the recovery of immune function, and help reduce the incidence of postoperative infection. Macrophages are an important type of immune cells that participate in the body's innate immunity. They have powerful phagocytosis and clearance functions. They can be polarized into M1 and M2 types under the regulation of the body, and play different roles in fighting microbial infections. Among them, the M1 type can participate in the elimination of pathogens. In this study, we will investigate the perioperative acupoint electrical stimulation to alleviate the immunosuppressive state of surgical stress mice, clarify the regulation of perioperative acupoint electrical stimulation on glucocorticoids and the relationship between NF-κB molecules and macrophage polarization.The key molecules of related pathways were verified by glucocorticoid receptor inhibitors, and it was found that electrical stimulation of acupoints during the perioperative period can affect the polarization of macrophages in surgically stressed mice to the M1 type by reducing the level of glucocorticoids and promoting the expression of NF κB molecules. Further reveal the partial mechanism of electroacupuncture regulating the anti-inflammatory and pro-inflammatory processes of macrophages in the immune response.https://doi.org/10.1186/s12950-023-00354-xElectrical acupoint stimulationMacrophageSurgical stressPerioperative period |
| spellingShingle | Yinzhou Zhang Junying Wei Xinyuan Wu Mengting Jiang Wuhua Ma Yuhui Li Effect of perioperative acupoint electrical stimulation on macrophages in mice under operative stress Journal of Inflammation Electrical acupoint stimulation Macrophage Surgical stress Perioperative period |
| title | Effect of perioperative acupoint electrical stimulation on macrophages in mice under operative stress |
| title_full | Effect of perioperative acupoint electrical stimulation on macrophages in mice under operative stress |
| title_fullStr | Effect of perioperative acupoint electrical stimulation on macrophages in mice under operative stress |
| title_full_unstemmed | Effect of perioperative acupoint electrical stimulation on macrophages in mice under operative stress |
| title_short | Effect of perioperative acupoint electrical stimulation on macrophages in mice under operative stress |
| title_sort | effect of perioperative acupoint electrical stimulation on macrophages in mice under operative stress |
| topic | Electrical acupoint stimulation Macrophage Surgical stress Perioperative period |
| url | https://doi.org/10.1186/s12950-023-00354-x |
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