Watch and wait strategies for rectal cancer: A systematic review
Watch and wait (WW) strategies have been suggested for patients with clinical complete regression (cCR). The WW approach was first introduced by Habr–Gama in patients with cCR after neoadjuvant treatment. Actually, it is not “no surgery” but “deferral of surgery;” therefore, the WW approach or non-o...
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| Format: | Article |
| Language: | English |
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Sungkyunkwan University School of Medi
2022-06-01
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| Series: | Precision and Future Medicine |
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| Online Access: | http://pfmjournal.org/upload/pdf/pfm-2021-00177.pdf |
| _version_ | 1828324489917628416 |
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| author | In Ja Park |
| author_facet | In Ja Park |
| author_sort | In Ja Park |
| collection | DOAJ |
| description | Watch and wait (WW) strategies have been suggested for patients with clinical complete regression (cCR). The WW approach was first introduced by Habr–Gama in patients with cCR after neoadjuvant treatment. Actually, it is not “no surgery” but “deferral of surgery;” therefore, the WW approach or non-operative management is a representative term currently. The number of publications regarding WW for rectal cancer has increased abruptly. We conducted a systematic review of PubMed for literature published on WW. It is now one of the most interesting issues in rectal cancer treatment. Many studies have reported comparable overall survival with WW and radical resection. However, a high local regrowth rate is a problem, and proper salvage management is the main concern in the WW approach. Adequate patient selection is necessary to achieve favorable oncologic outcomes. However, the appropriate definition and diagnostic method for cCR have not yet been clearly defined. Indeed, advances in local control have not translated into overall survival improvement, and many efforts have been made to improve distant metastasis control and overall survival and improve clinical response to preoperative chemoradiotherapy. In this review, oncologic outcomes, ongoing efforts to improve oncologic outcomes, and limitations for clinical practice were evaluated and described. |
| first_indexed | 2024-04-13T19:06:36Z |
| format | Article |
| id | doaj.art-0f8910b2a10d401d8afeb1a728ff9c01 |
| institution | Directory Open Access Journal |
| issn | 2508-7940 2508-7959 |
| language | English |
| last_indexed | 2024-04-13T19:06:36Z |
| publishDate | 2022-06-01 |
| publisher | Sungkyunkwan University School of Medi |
| record_format | Article |
| series | Precision and Future Medicine |
| spelling | doaj.art-0f8910b2a10d401d8afeb1a728ff9c012022-12-22T02:33:57ZengSungkyunkwan University School of MediPrecision and Future Medicine2508-79402508-79592022-06-01629110410.23838/pfm.2021.00177112Watch and wait strategies for rectal cancer: A systematic reviewIn Ja Park0 Department of Colon and Rectal Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaWatch and wait (WW) strategies have been suggested for patients with clinical complete regression (cCR). The WW approach was first introduced by Habr–Gama in patients with cCR after neoadjuvant treatment. Actually, it is not “no surgery” but “deferral of surgery;” therefore, the WW approach or non-operative management is a representative term currently. The number of publications regarding WW for rectal cancer has increased abruptly. We conducted a systematic review of PubMed for literature published on WW. It is now one of the most interesting issues in rectal cancer treatment. Many studies have reported comparable overall survival with WW and radical resection. However, a high local regrowth rate is a problem, and proper salvage management is the main concern in the WW approach. Adequate patient selection is necessary to achieve favorable oncologic outcomes. However, the appropriate definition and diagnostic method for cCR have not yet been clearly defined. Indeed, advances in local control have not translated into overall survival improvement, and many efforts have been made to improve distant metastasis control and overall survival and improve clinical response to preoperative chemoradiotherapy. In this review, oncologic outcomes, ongoing efforts to improve oncologic outcomes, and limitations for clinical practice were evaluated and described.http://pfmjournal.org/upload/pdf/pfm-2021-00177.pdfclinical complete regressionneoadjuvant therapyrectal neoplasmswatch and wait |
| spellingShingle | In Ja Park Watch and wait strategies for rectal cancer: A systematic review Precision and Future Medicine clinical complete regression neoadjuvant therapy rectal neoplasms watch and wait |
| title | Watch and wait strategies for rectal cancer: A systematic review |
| title_full | Watch and wait strategies for rectal cancer: A systematic review |
| title_fullStr | Watch and wait strategies for rectal cancer: A systematic review |
| title_full_unstemmed | Watch and wait strategies for rectal cancer: A systematic review |
| title_short | Watch and wait strategies for rectal cancer: A systematic review |
| title_sort | watch and wait strategies for rectal cancer a systematic review |
| topic | clinical complete regression neoadjuvant therapy rectal neoplasms watch and wait |
| url | http://pfmjournal.org/upload/pdf/pfm-2021-00177.pdf |
| work_keys_str_mv | AT injapark watchandwaitstrategiesforrectalcancerasystematicreview |