Effectiveness, barriers and facilitating factors of strategies for active delabelling of patients with penicillin allergy labels: a systematic review protocol
Introduction Up to 15% of adult patients in the clinical setting report to be allergic to penicillin. However, in most cases, penicillin allergy is not confirmed. Due to the negative aspects associated with erroneous penicillin allergy, the implementation of active delabelling processes for penicill...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-02-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/2/e077927.full |
| _version_ | 1797270742705897472 |
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| author | Torsten Hoppe-Tichy Benedict Morath Claudia Denkinger Elham Khatamzas Hannah Nürnberg Tabea Krause Lars Oetken Sophie Rauer Amelie Rapp |
| author_facet | Torsten Hoppe-Tichy Benedict Morath Claudia Denkinger Elham Khatamzas Hannah Nürnberg Tabea Krause Lars Oetken Sophie Rauer Amelie Rapp |
| author_sort | Torsten Hoppe-Tichy |
| collection | DOAJ |
| description | Introduction Up to 15% of adult patients in the clinical setting report to be allergic to penicillin. However, in most cases, penicillin allergy is not confirmed. Due to the negative aspects associated with erroneous penicillin allergy, the implementation of active delabelling processes for penicillin allergy is an important part of antibiotic stewardship programmes. Depending on the clinical setting, different factors need to be considered during implementation. This review examines the effectiveness of different delabelling interventions and summarises components and structures that facilitate, support or constrain structured penicillin allergy delabelling.Methods and analysis This review will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The databases MEDLINE (via PubMed), EMBASE and Cochrane Library were searched for studies reporting on any intervention to identify, assess or rule out uncertain penicillin allergy. To improve completeness, two further databases are also searched for grey literature. Study design, intervention type, professional groups involved, effectiveness, limitations, barriers, facilitating factors, clinical setting and associated regulatory factors will be extracted and analysed. In addition, exclusion criteria for participation in the delabelling intervention and criteria for not delabelling penicillin allergy will be summarised. In case of failed protocols, these are highlighted and quantitatively analysed if possible. Two independent reviewers will perform the screening process and data extraction. Discordant decisions will be resolved through review by a third reviewer. Bias assessment of the individual studies will be performed using the Newcastle Ottawa Scale.Ethics and dissemination Because individual patient-related data are not analysed, an ethical approval is not required. The review will be published in a peer-reviewed scientific journal. |
| first_indexed | 2024-03-07T21:23:34Z |
| format | Article |
| id | doaj.art-0f8b5d8060aa4b579e793ffcd7b84800 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-04-25T02:09:06Z |
| publishDate | 2024-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-0f8b5d8060aa4b579e793ffcd7b848002024-03-07T12:25:06ZengBMJ Publishing GroupBMJ Open2044-60552024-02-0114210.1136/bmjopen-2023-077927Effectiveness, barriers and facilitating factors of strategies for active delabelling of patients with penicillin allergy labels: a systematic review protocolTorsten Hoppe-Tichy0Benedict Morath1Claudia Denkinger2Elham Khatamzas3Hannah Nürnberg4Tabea Krause5Lars Oetken6Sophie Rauer7Amelie Rapp8Hospital Pharmacy, University Hospital Heidelberg, Heidelberg University, Heidelberg, Baden-Württemberg, GermanyHospital Pharmacy, University Hospital Heidelberg, Heidelberg University, Heidelberg, Baden-Württemberg, GermanyDivision of Infectious Diseases and Tropical Medicine, University Hospital Heidelberg, Heidelberg University, Heidelberg, Baden-Württemberg, GermanyDivision of Infectious Diseases and Tropical Medicine, University Hospital Heidelberg, Heidelberg University, Heidelberg, Baden-Württemberg, GermanyHospital Pharmacy, University Hospital Heidelberg, Heidelberg University, Heidelberg, Baden-Württemberg, GermanyHospital Pharmacy, University Hospital Heidelberg, Heidelberg University, Heidelberg, Baden-Württemberg, GermanyHospital Pharmacy, University Hospital Heidelberg, Heidelberg University, Heidelberg, Baden-Württemberg, GermanyHospital Pharmacy, University Hospital Heidelberg, Heidelberg University, Heidelberg, Baden-Württemberg, GermanyHospital Pharmacy, University Hospital Heidelberg, Heidelberg University, Heidelberg, Baden-Württemberg, GermanyIntroduction Up to 15% of adult patients in the clinical setting report to be allergic to penicillin. However, in most cases, penicillin allergy is not confirmed. Due to the negative aspects associated with erroneous penicillin allergy, the implementation of active delabelling processes for penicillin allergy is an important part of antibiotic stewardship programmes. Depending on the clinical setting, different factors need to be considered during implementation. This review examines the effectiveness of different delabelling interventions and summarises components and structures that facilitate, support or constrain structured penicillin allergy delabelling.Methods and analysis This review will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The databases MEDLINE (via PubMed), EMBASE and Cochrane Library were searched for studies reporting on any intervention to identify, assess or rule out uncertain penicillin allergy. To improve completeness, two further databases are also searched for grey literature. Study design, intervention type, professional groups involved, effectiveness, limitations, barriers, facilitating factors, clinical setting and associated regulatory factors will be extracted and analysed. In addition, exclusion criteria for participation in the delabelling intervention and criteria for not delabelling penicillin allergy will be summarised. In case of failed protocols, these are highlighted and quantitatively analysed if possible. Two independent reviewers will perform the screening process and data extraction. Discordant decisions will be resolved through review by a third reviewer. Bias assessment of the individual studies will be performed using the Newcastle Ottawa Scale.Ethics and dissemination Because individual patient-related data are not analysed, an ethical approval is not required. The review will be published in a peer-reviewed scientific journal.https://bmjopen.bmj.com/content/14/2/e077927.full |
| spellingShingle | Torsten Hoppe-Tichy Benedict Morath Claudia Denkinger Elham Khatamzas Hannah Nürnberg Tabea Krause Lars Oetken Sophie Rauer Amelie Rapp Effectiveness, barriers and facilitating factors of strategies for active delabelling of patients with penicillin allergy labels: a systematic review protocol BMJ Open |
| title | Effectiveness, barriers and facilitating factors of strategies for active delabelling of patients with penicillin allergy labels: a systematic review protocol |
| title_full | Effectiveness, barriers and facilitating factors of strategies for active delabelling of patients with penicillin allergy labels: a systematic review protocol |
| title_fullStr | Effectiveness, barriers and facilitating factors of strategies for active delabelling of patients with penicillin allergy labels: a systematic review protocol |
| title_full_unstemmed | Effectiveness, barriers and facilitating factors of strategies for active delabelling of patients with penicillin allergy labels: a systematic review protocol |
| title_short | Effectiveness, barriers and facilitating factors of strategies for active delabelling of patients with penicillin allergy labels: a systematic review protocol |
| title_sort | effectiveness barriers and facilitating factors of strategies for active delabelling of patients with penicillin allergy labels a systematic review protocol |
| url | https://bmjopen.bmj.com/content/14/2/e077927.full |
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