A redox switch regulates the assembly and anti-CRISPR activity of AcrIIC1

A redox switch regulates the assembly and anti-CRISPR activity of AcrIIC1

Here, the authors report the discovery of a redox switch for AcrIIC1, which regulates AcrIIC1’s monomer-dimer interconversion and inhibitory activity on Cas9. By reporting the structures of different redox states of NmeAcrIIC1, they identify a pair of conserved cysteines which mediate the redox swit...

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Bibliographic Details
Main Authors: Yanan Zhao, Jiaojiao Hu, Shan-Shan Yang, Jing Zhong, Jianping Liu, Shuo Wang, Yuzhuo Jiao, Fang Jiang, Ruiyang Zhai, Bingnan Ren, Hua Cong, Yuwei Zhu, Fengtong Han, Jixian Zhang, Yue Xu, Zhiwei Huang, Shengnan Zhang, Fan Yang
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34551-8

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