Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease
Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal (GI) disorder characterized by intestinal inflammation. The etiology of IBD is multifactorial and results from a complex interplay between mucosal immunity, environmental factors, and host genetics. Future therapeutics for GI...
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| Format: | Article |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1217165/full |
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| author | Dipak Kumar Sahoo Romy M. Heilmann Biswaranjan Paital Ashish Patel Virendra Kumar Yadav David Wong Albert E. Jergens |
| author_facet | Dipak Kumar Sahoo Romy M. Heilmann Biswaranjan Paital Ashish Patel Virendra Kumar Yadav David Wong Albert E. Jergens |
| author_sort | Dipak Kumar Sahoo |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal (GI) disorder characterized by intestinal inflammation. The etiology of IBD is multifactorial and results from a complex interplay between mucosal immunity, environmental factors, and host genetics. Future therapeutics for GI disorders, including IBD, that are driven by oxidative stress require a greater understanding of the cellular and molecular mechanisms mediated by reactive oxygen species (ROS). In the GI tract, oxidative stressors include infections and pro-inflammatory responses, which boost ROS generation by promoting the production of pro-inflammatory cytokines. Nuclear factor kappa B (NF-κB) and nuclear factor erythroid 2–related factor 2 (Nrf2) represent two important signaling pathways in intestinal immune cells that regulate numerous physiological processes, including anti-inflammatory and antioxidant activities. Natural antioxidant compounds exhibit ROS scavenging and increase antioxidant defense capacity to inhibit pro-oxidative enzymes, which may be useful in IBD treatment. In this review, we discuss various polyphenolic substances (such as resveratrol, curcumin, quercetin, green tea flavonoids, caffeic acid phenethyl ester, luteolin, xanthohumol, genistein, alpinetin, proanthocyanidins, anthocyanins, silymarin), phenolic compounds including thymol, alkaloids such as berberine, storage polysaccharides such as tamarind xyloglucan, and other phytochemicals represented by isothiocyanate sulforaphane and food/spices (such as ginger, flaxseed oil), as well as antioxidant hormones like melatonin that target cellular signaling pathways to reduce intestinal inflammation occurring with IBD. |
| first_indexed | 2024-03-12T13:08:00Z |
| format | Article |
| id | doaj.art-0f8cfd0651224e11850b53e97201cc24 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-12T13:08:00Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-0f8cfd0651224e11850b53e97201cc242023-08-28T11:39:18ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-08-011410.3389/fendo.2023.12171651217165Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel diseaseDipak Kumar Sahoo0Romy M. Heilmann1Biswaranjan Paital2Ashish Patel3Virendra Kumar Yadav4David Wong5Albert E. Jergens6Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, United StatesDepartment for Small Animals, Veterinary Teaching Hospital, College of Veterinary Medicine, University of Leipzig, Leipzig, SN, GermanyRedox Regulation Laboratory, Department of Zoology, College of Basic Science and Humanities, Odisha University of Agriculture and Technology, Bhubaneswar, IndiaDepartment of Life Sciences, Hemchandracharya North Gujarat University, Patan, Gujarat, IndiaDepartment of Life Sciences, Hemchandracharya North Gujarat University, Patan, Gujarat, IndiaDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, United StatesDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, United StatesInflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal (GI) disorder characterized by intestinal inflammation. The etiology of IBD is multifactorial and results from a complex interplay between mucosal immunity, environmental factors, and host genetics. Future therapeutics for GI disorders, including IBD, that are driven by oxidative stress require a greater understanding of the cellular and molecular mechanisms mediated by reactive oxygen species (ROS). In the GI tract, oxidative stressors include infections and pro-inflammatory responses, which boost ROS generation by promoting the production of pro-inflammatory cytokines. Nuclear factor kappa B (NF-κB) and nuclear factor erythroid 2–related factor 2 (Nrf2) represent two important signaling pathways in intestinal immune cells that regulate numerous physiological processes, including anti-inflammatory and antioxidant activities. Natural antioxidant compounds exhibit ROS scavenging and increase antioxidant defense capacity to inhibit pro-oxidative enzymes, which may be useful in IBD treatment. In this review, we discuss various polyphenolic substances (such as resveratrol, curcumin, quercetin, green tea flavonoids, caffeic acid phenethyl ester, luteolin, xanthohumol, genistein, alpinetin, proanthocyanidins, anthocyanins, silymarin), phenolic compounds including thymol, alkaloids such as berberine, storage polysaccharides such as tamarind xyloglucan, and other phytochemicals represented by isothiocyanate sulforaphane and food/spices (such as ginger, flaxseed oil), as well as antioxidant hormones like melatonin that target cellular signaling pathways to reduce intestinal inflammation occurring with IBD.https://www.frontiersin.org/articles/10.3389/fendo.2023.1217165/fullantioxidantsulcerative colitisCrohn’s diseaseIBDoxidative stressflavonoids |
| spellingShingle | Dipak Kumar Sahoo Romy M. Heilmann Biswaranjan Paital Ashish Patel Virendra Kumar Yadav David Wong Albert E. Jergens Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease Frontiers in Endocrinology antioxidants ulcerative colitis Crohn’s disease IBD oxidative stress flavonoids |
| title | Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease |
| title_full | Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease |
| title_fullStr | Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease |
| title_full_unstemmed | Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease |
| title_short | Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease |
| title_sort | oxidative stress hormones and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease |
| topic | antioxidants ulcerative colitis Crohn’s disease IBD oxidative stress flavonoids |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1217165/full |
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