Heterocyclic Crown Ethers with Potential Biological and Pharmacological Properties: From Synthesis to Applications
Cyclic organic compounds with several ether linkages in their structure are of much concern in our daily life applications. Crown ethers (CEs) are generally heterocyclic and extremely versatile compounds exhibiting higher binding affinity. In recent years, due to their unique structure, crown ethers...
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MDPI AG
2022-01-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/12/3/1102 |
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| author | Faiz Ullah Taskin Aman Khan Jawaria Iltaf Saleha Anwar Muhammad Farhan Ali Khan Muhammad Rizwan Khan Sami Ullah Muhammad Fayyaz ur Rehman Muhammad Mustaqeem Katarzyna Kotwica-Mojzych Mariusz Mojzych |
| author_facet | Faiz Ullah Taskin Aman Khan Jawaria Iltaf Saleha Anwar Muhammad Farhan Ali Khan Muhammad Rizwan Khan Sami Ullah Muhammad Fayyaz ur Rehman Muhammad Mustaqeem Katarzyna Kotwica-Mojzych Mariusz Mojzych |
| author_sort | Faiz Ullah |
| collection | DOAJ |
| description | Cyclic organic compounds with several ether linkages in their structure are of much concern in our daily life applications. Crown ethers (CEs) are generally heterocyclic and extremely versatile compounds exhibiting higher binding affinity. In recent years, due to their unique structure, crown ethers are widely used in drug delivery, solvent extraction, cosmetics manufacturing, material studies, catalysis, separation, and organic synthesis. Beyond their conventional place in chemistry, this review article summarizes the synthesis, biological, and potential pharmacological activities of CEs. We have emphasized the prospects of CEs as anticancer, anti-inflammatory, antibacterial, and antifungal agents and have explored their amyloid genesis inhibitory activity, electrochemical, and potential metric sensing properties. The central feature of these compounds is their ability to form selective and stable complexes with various organic and inorganic cations. Therefore, CEs can be used in gas chromatography as the stationary phase and are also valuable for cation chromatographic to determine and separate alkali and alkaline-earth cations. |
| first_indexed | 2024-03-10T00:15:38Z |
| format | Article |
| id | doaj.art-0f9013afde244afe8ec165059260f7a7 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T00:15:38Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-0f9013afde244afe8ec165059260f7a72023-11-23T15:51:57ZengMDPI AGApplied Sciences2076-34172022-01-01123110210.3390/app12031102Heterocyclic Crown Ethers with Potential Biological and Pharmacological Properties: From Synthesis to ApplicationsFaiz Ullah0Taskin Aman Khan1Jawaria Iltaf2Saleha Anwar3Muhammad Farhan Ali Khan4Muhammad Rizwan Khan5Sami Ullah6Muhammad Fayyaz ur Rehman7Muhammad Mustaqeem8Katarzyna Kotwica-Mojzych9Mariusz Mojzych10Department of Chemistry, Quaid I Azam University, Islamabad 45320, PakistanInstitute of Chemistry, University of Sargodha, Sargodha 40100, PakistanInstitute of Chemistry, University of Sargodha, Sargodha 40100, PakistanDepartment of Chemistry, International Islamic University, Islamabad 45320, PakistanDepartment of Pharmacy, Quaid I Azam University, Islamabad 45320, PakistanDepartment of Chemistry, Allama Iqbal Open University, Islamabad 45320, PakistanDepartment of Zoology, Government College University, Faisalabad 38000, PakistanInstitute of Chemistry, University of Sargodha, Sargodha 40100, PakistanDepartment of Chemistry, Sub Campus, University of Sargodha, Bhakkar 30000, PakistanDepartment of Histology, Embryology and Cytophysiology, Medical University of Lublin, Radziwiłłowska 11, 20-080 Lublin, PolandDepartment of Chemistry, Siedlce University of Natural Sciences and Humanities, 3-go Maja 54, 08-110 Siedlce, PolandCyclic organic compounds with several ether linkages in their structure are of much concern in our daily life applications. Crown ethers (CEs) are generally heterocyclic and extremely versatile compounds exhibiting higher binding affinity. In recent years, due to their unique structure, crown ethers are widely used in drug delivery, solvent extraction, cosmetics manufacturing, material studies, catalysis, separation, and organic synthesis. Beyond their conventional place in chemistry, this review article summarizes the synthesis, biological, and potential pharmacological activities of CEs. We have emphasized the prospects of CEs as anticancer, anti-inflammatory, antibacterial, and antifungal agents and have explored their amyloid genesis inhibitory activity, electrochemical, and potential metric sensing properties. The central feature of these compounds is their ability to form selective and stable complexes with various organic and inorganic cations. Therefore, CEs can be used in gas chromatography as the stationary phase and are also valuable for cation chromatographic to determine and separate alkali and alkaline-earth cations.https://www.mdpi.com/2076-3417/12/3/1102crown ethersiontophoresisheterocyclic compoundsmacrocyclic polyether |
| spellingShingle | Faiz Ullah Taskin Aman Khan Jawaria Iltaf Saleha Anwar Muhammad Farhan Ali Khan Muhammad Rizwan Khan Sami Ullah Muhammad Fayyaz ur Rehman Muhammad Mustaqeem Katarzyna Kotwica-Mojzych Mariusz Mojzych Heterocyclic Crown Ethers with Potential Biological and Pharmacological Properties: From Synthesis to Applications Applied Sciences crown ethers iontophoresis heterocyclic compounds macrocyclic polyether |
| title | Heterocyclic Crown Ethers with Potential Biological and Pharmacological Properties: From Synthesis to Applications |
| title_full | Heterocyclic Crown Ethers with Potential Biological and Pharmacological Properties: From Synthesis to Applications |
| title_fullStr | Heterocyclic Crown Ethers with Potential Biological and Pharmacological Properties: From Synthesis to Applications |
| title_full_unstemmed | Heterocyclic Crown Ethers with Potential Biological and Pharmacological Properties: From Synthesis to Applications |
| title_short | Heterocyclic Crown Ethers with Potential Biological and Pharmacological Properties: From Synthesis to Applications |
| title_sort | heterocyclic crown ethers with potential biological and pharmacological properties from synthesis to applications |
| topic | crown ethers iontophoresis heterocyclic compounds macrocyclic polyether |
| url | https://www.mdpi.com/2076-3417/12/3/1102 |
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