Neural, physiological, and psychological markers of appetitive conditioning in anorexia nervosa: a study protocol
Abstract Background Anorexia nervosa (AN) is a chronic and disabling psychiatric condition characterized by low hedonic drive towards food, and is thought to be inclusive of altered dimensions of reward processing. Whether there exists a fundamental aberrancy in the capacity to acquire and maintain...
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | Journal of Eating Disorders |
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| Online Access: | https://doi.org/10.1186/s40337-022-00546-5 |
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| author | Stuart B. Murray Tomislav D. Zbozinek Michelle Craske Reza Tadayonnejad Michael Strober Ausaf A. Bari John P. O’Doherty Jamie D. Feusner |
| author_facet | Stuart B. Murray Tomislav D. Zbozinek Michelle Craske Reza Tadayonnejad Michael Strober Ausaf A. Bari John P. O’Doherty Jamie D. Feusner |
| author_sort | Stuart B. Murray |
| collection | DOAJ |
| description | Abstract Background Anorexia nervosa (AN) is a chronic and disabling psychiatric condition characterized by low hedonic drive towards food, and is thought to be inclusive of altered dimensions of reward processing. Whether there exists a fundamental aberrancy in the capacity to acquire and maintain de novo hedonic associations—a critical component of hedonic responding—has never been studied in AN. Methods This multi-modal study will employ a 2-day Pavlovian appetitive conditioning paradigm to interrogate the (1) acquisition, (2) extinction, (3) spontaneous recovery and (4) reinstatement of appetitive learning in adolescents and young adults with AN. Participants will be 30 currently ill, underweight individuals with AN; 30 weight-restored individuals with AN; and 30 age-matched healthy controls, all aged 12–22 years. All subjects will undergo clinical assessment, followed by the 2-day appetitive conditioning task during which fMRI, pupillometry, heart rate deceleration, and subjective ratings will be acquired. Discussion This study will be the first to interrogate appetitive conditioning in AN—a disorder characterized by altered hedonic responding to food. Results will help establish objective biomarkers of appetitive conditioning in AN and lay the groundwork for developing novel lines of treatment for AN and other psychiatric disorders involving diminished ability to experience pleasure and reward. Trial registration: Pending. Intended registry Clinicaltrials.gov. |
| first_indexed | 2024-03-12T07:37:58Z |
| format | Article |
| id | doaj.art-0f90609eba684c118f72ef52f7454785 |
| institution | Directory Open Access Journal |
| issn | 2050-2974 |
| language | English |
| last_indexed | 2024-03-12T07:37:58Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Eating Disorders |
| spelling | doaj.art-0f90609eba684c118f72ef52f74547852023-09-02T21:26:30ZengBMCJournal of Eating Disorders2050-29742022-05-0110111110.1186/s40337-022-00546-5Neural, physiological, and psychological markers of appetitive conditioning in anorexia nervosa: a study protocolStuart B. Murray0Tomislav D. Zbozinek1Michelle Craske2Reza Tadayonnejad3Michael Strober4Ausaf A. Bari5John P. O’Doherty6Jamie D. Feusner7Department of Psychiatry and Behavioral Sciences, University of Southern CaliforniaDivision of Humanities and Social Sciences, California Institute of TechnologyDepartment of Psychology, University of California, Los AngelesDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los AngelesDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los AngelesDepartment of Neurosurgery, University of California, Los AngelesDivision of Humanities and Social Sciences, California Institute of TechnologyDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los AngelesAbstract Background Anorexia nervosa (AN) is a chronic and disabling psychiatric condition characterized by low hedonic drive towards food, and is thought to be inclusive of altered dimensions of reward processing. Whether there exists a fundamental aberrancy in the capacity to acquire and maintain de novo hedonic associations—a critical component of hedonic responding—has never been studied in AN. Methods This multi-modal study will employ a 2-day Pavlovian appetitive conditioning paradigm to interrogate the (1) acquisition, (2) extinction, (3) spontaneous recovery and (4) reinstatement of appetitive learning in adolescents and young adults with AN. Participants will be 30 currently ill, underweight individuals with AN; 30 weight-restored individuals with AN; and 30 age-matched healthy controls, all aged 12–22 years. All subjects will undergo clinical assessment, followed by the 2-day appetitive conditioning task during which fMRI, pupillometry, heart rate deceleration, and subjective ratings will be acquired. Discussion This study will be the first to interrogate appetitive conditioning in AN—a disorder characterized by altered hedonic responding to food. Results will help establish objective biomarkers of appetitive conditioning in AN and lay the groundwork for developing novel lines of treatment for AN and other psychiatric disorders involving diminished ability to experience pleasure and reward. Trial registration: Pending. Intended registry Clinicaltrials.gov.https://doi.org/10.1186/s40337-022-00546-5Anorexia nervosaEating disordersRewardAppetitive conditioningfMRI |
| spellingShingle | Stuart B. Murray Tomislav D. Zbozinek Michelle Craske Reza Tadayonnejad Michael Strober Ausaf A. Bari John P. O’Doherty Jamie D. Feusner Neural, physiological, and psychological markers of appetitive conditioning in anorexia nervosa: a study protocol Journal of Eating Disorders Anorexia nervosa Eating disorders Reward Appetitive conditioning fMRI |
| title | Neural, physiological, and psychological markers of appetitive conditioning in anorexia nervosa: a study protocol |
| title_full | Neural, physiological, and psychological markers of appetitive conditioning in anorexia nervosa: a study protocol |
| title_fullStr | Neural, physiological, and psychological markers of appetitive conditioning in anorexia nervosa: a study protocol |
| title_full_unstemmed | Neural, physiological, and psychological markers of appetitive conditioning in anorexia nervosa: a study protocol |
| title_short | Neural, physiological, and psychological markers of appetitive conditioning in anorexia nervosa: a study protocol |
| title_sort | neural physiological and psychological markers of appetitive conditioning in anorexia nervosa a study protocol |
| topic | Anorexia nervosa Eating disorders Reward Appetitive conditioning fMRI |
| url | https://doi.org/10.1186/s40337-022-00546-5 |
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