Targeting RAS phosphorylation in cancer therapy: Mechanisms and modulators

Targeting RAS phosphorylation in cancer therapy: Mechanisms and modulators

RAS, a member of the small GTPase family, functions as a binary switch by shifting between inactive GDP-loaded and active GTP-loaded state. RAS gain-of-function mutations are one of the leading causes in human oncogenesis, accounting for ∼19% of the global cancer burden. As a well-recognized target...

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Bibliographic Details
Main Authors: Yuran Qiu, Yuanhao Wang, Zongtao Chai, Duan Ni, Xinyi Li, Jun Pu, Jie Chen, Jian Zhang, Shaoyong Lu, Chuan Lv, Mingfei Ji
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Acta Pharmaceutica Sinica B
Subjects:
RAS
Phosphorylation
Undruggable
Protein kinases
Allostery
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521000629

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