Synthetic glycolipid-based TLR4 antagonists negatively regulate TRIF-dependent TLR4 signalling in human macrophages

Synthetic glycolipid-based TLR4 antagonists negatively regulate TRIF-dependent TLR4 signalling in human macrophages

TLRs, including TLR4, play a crucial role in inflammatory-based diseases, and TLR4 has been identified as a therapeutic target for pharmacological intervention. In previous studies, we investigated the potential of FP7, a novel synthetic glycolipid active as a TLR4 antagonist, to inhibit haematopoie...

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Bibliographic Details
Main Authors: Charys Palmer, Fabio A Facchini, Richard PO Jones, Frank Neumann, Francesco Peri, Grisha Pirianov
Format: Article
Language:English
Published: SAGE Publishing 2021-04-01
Series:Innate Immunity
Online Access:https://doi.org/10.1177/17534259211005840

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