A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression
Abstract Minichromosome Maintenance Complex Component 3 Associated Protein Antisense 1 (MCM3AP-AS1) is an RNA gene located on 21q22.3. The sense transcript from this locus has dual roles in the pathogenesis of solid tumors and hematological malignancies. MCM3AP-AS1 has been shown to sequester miR-19...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-07-01
|
| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-022-02644-5 |
| _version_ | 1811219268281303040 |
|---|---|
| author | Soudeh Ghafouri-Fard Tayyebeh Khoshbakht Bashdar Mahmud Hussen Mohammad Taheri Mohammad Samadian |
| author_facet | Soudeh Ghafouri-Fard Tayyebeh Khoshbakht Bashdar Mahmud Hussen Mohammad Taheri Mohammad Samadian |
| author_sort | Soudeh Ghafouri-Fard |
| collection | DOAJ |
| description | Abstract Minichromosome Maintenance Complex Component 3 Associated Protein Antisense 1 (MCM3AP-AS1) is an RNA gene located on 21q22.3. The sense transcript from this locus has dual roles in the pathogenesis of solid tumors and hematological malignancies. MCM3AP-AS1 has been shown to sequester miR-194-5p, miR-876-5p, miR-543-3p, miR-28-5p, miR-93, miR-545, miR-599, miR‐193a‐5p, miR-363-5p, miR-204-5p, miR-211-5p, miR-15a, miR-708-5p, miR-138, miR-138-5p, miR-34a, miR-211, miR‐340‐5p, miR-148a, miR-195-5p and miR-126. Some cancer-related signaling pathway, namely PTEN/AKT, PI3K/AKT and ERK1/2 are influenced by this lncRNA. Cell line studies, animal studies and clinical studies have consistently reported oncogenic role of MCM3AP-AS1 in different tissues except for cervical cancer in which this lncRNA has tumor suppressor role. In the current manuscript, we collected evidence from these three sources of evidence to review the impact of MCM3AP-AS1 in the carcinogenesis. |
| first_indexed | 2024-04-12T07:22:17Z |
| format | Article |
| id | doaj.art-0f95510125c948c399b644de283b13bd |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-04-12T07:22:17Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-0f95510125c948c399b644de283b13bd2022-12-22T03:42:16ZengBMCCancer Cell International1475-28672022-07-0122111410.1186/s12935-022-02644-5A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progressionSoudeh Ghafouri-Fard0Tayyebeh Khoshbakht1Bashdar Mahmud Hussen2Mohammad Taheri3Mohammad Samadian4Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical SciencesPhytochemistry Research Center, Shahid Beheshti University of Medical SciencesDepartment of Pharmacognosy, College of Pharmacy, Hawler Medical UniversityInstitute of Human Genetics, Jena University HospitalSkull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical SciencesAbstract Minichromosome Maintenance Complex Component 3 Associated Protein Antisense 1 (MCM3AP-AS1) is an RNA gene located on 21q22.3. The sense transcript from this locus has dual roles in the pathogenesis of solid tumors and hematological malignancies. MCM3AP-AS1 has been shown to sequester miR-194-5p, miR-876-5p, miR-543-3p, miR-28-5p, miR-93, miR-545, miR-599, miR‐193a‐5p, miR-363-5p, miR-204-5p, miR-211-5p, miR-15a, miR-708-5p, miR-138, miR-138-5p, miR-34a, miR-211, miR‐340‐5p, miR-148a, miR-195-5p and miR-126. Some cancer-related signaling pathway, namely PTEN/AKT, PI3K/AKT and ERK1/2 are influenced by this lncRNA. Cell line studies, animal studies and clinical studies have consistently reported oncogenic role of MCM3AP-AS1 in different tissues except for cervical cancer in which this lncRNA has tumor suppressor role. In the current manuscript, we collected evidence from these three sources of evidence to review the impact of MCM3AP-AS1 in the carcinogenesis.https://doi.org/10.1186/s12935-022-02644-5MCM3AP-AS1lncRNACancer |
| spellingShingle | Soudeh Ghafouri-Fard Tayyebeh Khoshbakht Bashdar Mahmud Hussen Mohammad Taheri Mohammad Samadian A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression Cancer Cell International MCM3AP-AS1 lncRNA Cancer |
| title | A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression |
| title_full | A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression |
| title_fullStr | A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression |
| title_full_unstemmed | A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression |
| title_short | A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression |
| title_sort | review on the role of mcm3ap as1 in the carcinogenesis and tumor progression |
| topic | MCM3AP-AS1 lncRNA Cancer |
| url | https://doi.org/10.1186/s12935-022-02644-5 |
| work_keys_str_mv | AT soudehghafourifard areviewontheroleofmcm3apas1inthecarcinogenesisandtumorprogression AT tayyebehkhoshbakht areviewontheroleofmcm3apas1inthecarcinogenesisandtumorprogression AT bashdarmahmudhussen areviewontheroleofmcm3apas1inthecarcinogenesisandtumorprogression AT mohammadtaheri areviewontheroleofmcm3apas1inthecarcinogenesisandtumorprogression AT mohammadsamadian areviewontheroleofmcm3apas1inthecarcinogenesisandtumorprogression AT soudehghafourifard reviewontheroleofmcm3apas1inthecarcinogenesisandtumorprogression AT tayyebehkhoshbakht reviewontheroleofmcm3apas1inthecarcinogenesisandtumorprogression AT bashdarmahmudhussen reviewontheroleofmcm3apas1inthecarcinogenesisandtumorprogression AT mohammadtaheri reviewontheroleofmcm3apas1inthecarcinogenesisandtumorprogression AT mohammadsamadian reviewontheroleofmcm3apas1inthecarcinogenesisandtumorprogression |