Fluoroscence bronhoscopy

Background. Fluorescence bronchoscopy is one of the methods of the early detection of lung cancer that involves the large airways. The method is based on the detection of the altered autofluorescence of malignantly transformed tissue, and confirmed by biopsy and histopathologic examination. Method....

Full description

Bibliographic Details
Main Authors: Tomić Ilija, Mrđa Vladimir, Karličić Vukojica, Bokun Radojka, Tatomirović Željka
Format: Article
Language:English
Published: Military Health Department, Ministry of Defance, Serbia 2003-01-01
Series:Vojnosanitetski Pregled
Subjects:
Online Access:http://www.doiserbia.nb.rs/img/doi/0042-8450/2003/0042-84500302161T.pdf
_version_ 1818944435763806208
author Tomić Ilija
Mrđa Vladimir
Karličić Vukojica
Bokun Radojka
Tatomirović Željka
author_facet Tomić Ilija
Mrđa Vladimir
Karličić Vukojica
Bokun Radojka
Tatomirović Željka
author_sort Tomić Ilija
collection DOAJ
description Background. Fluorescence bronchoscopy is one of the methods of the early detection of lung cancer that involves the large airways. The method is based on the detection of the altered autofluorescence of malignantly transformed tissue, and confirmed by biopsy and histopathologic examination. Method. Fluorescence bronchoscopy was performed in 18 patients, mean age of 51.2 years (male n=12, female n=6) due to the suspected lung cancer. Fluorescence bronchoscopy was performed using the Xillix LIFE-Lung System Vancouver, Canada. After conventional white-light bronchoscopy, the tracheobronchial tree was illuminated by blue light (442 nm) using helium-cadmium laser, and the results of autofluorescence were classified into three classes. Normal mucosa was of green fluorescence (Class I) abnormal mucosa was red or dark brown fluorescence (Class II and II), which was the indication for performing biopsy. Results. Normal endoscopy findings were established in 15 patients by conventional bronchoscopy. In the same group, by fluorescence bronchoscopy, Class I of fluorescence (normal finding) was found in 9 patients, while Class II changes occured in 6 patients. Histopathologic analysis of bronchial mucosa with Class II changes was performed detecting planocellular carcinoma in situ in one patient. Tumor-like changes were detected in 3 patients by conventional bronchoscopy and were determined as Class III changes by fluorescence bronchoscopy. By the biopsy of these chages carcinoma was documented in 2 patients while in one patient metaplasia of epithelium and granulation tissue around aspirated foreign body was detected. Conclusion. Fluorescence bronchoscopy is one of the methods for detecting metaplasia, carcinoma in situ and cancerous changes of bronchial epithelium in the large airways. However, the high rate of falsely positive findings represents a limitation of this method.
first_indexed 2024-12-20T07:43:11Z
format Article
id doaj.art-0f9829a5be5144d8bb5d73393760a4dc
institution Directory Open Access Journal
issn 0042-8450
language English
last_indexed 2024-12-20T07:43:11Z
publishDate 2003-01-01
publisher Military Health Department, Ministry of Defance, Serbia
record_format Article
series Vojnosanitetski Pregled
spelling doaj.art-0f9829a5be5144d8bb5d73393760a4dc2022-12-21T19:48:04ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502003-01-0160216116610.2298/VSP0302161TFluoroscence bronhoscopyTomić IlijaMrđa VladimirKarličić VukojicaBokun RadojkaTatomirović ŽeljkaBackground. Fluorescence bronchoscopy is one of the methods of the early detection of lung cancer that involves the large airways. The method is based on the detection of the altered autofluorescence of malignantly transformed tissue, and confirmed by biopsy and histopathologic examination. Method. Fluorescence bronchoscopy was performed in 18 patients, mean age of 51.2 years (male n=12, female n=6) due to the suspected lung cancer. Fluorescence bronchoscopy was performed using the Xillix LIFE-Lung System Vancouver, Canada. After conventional white-light bronchoscopy, the tracheobronchial tree was illuminated by blue light (442 nm) using helium-cadmium laser, and the results of autofluorescence were classified into three classes. Normal mucosa was of green fluorescence (Class I) abnormal mucosa was red or dark brown fluorescence (Class II and II), which was the indication for performing biopsy. Results. Normal endoscopy findings were established in 15 patients by conventional bronchoscopy. In the same group, by fluorescence bronchoscopy, Class I of fluorescence (normal finding) was found in 9 patients, while Class II changes occured in 6 patients. Histopathologic analysis of bronchial mucosa with Class II changes was performed detecting planocellular carcinoma in situ in one patient. Tumor-like changes were detected in 3 patients by conventional bronchoscopy and were determined as Class III changes by fluorescence bronchoscopy. By the biopsy of these chages carcinoma was documented in 2 patients while in one patient metaplasia of epithelium and granulation tissue around aspirated foreign body was detected. Conclusion. Fluorescence bronchoscopy is one of the methods for detecting metaplasia, carcinoma in situ and cancerous changes of bronchial epithelium in the large airways. However, the high rate of falsely positive findings represents a limitation of this method.http://www.doiserbia.nb.rs/img/doi/0042-8450/2003/0042-84500302161T.pdfbronchial neoplasmslung neoplasmsbronchoscopyfluorescencediagnosisdifferentialsensitivity and specificity
spellingShingle Tomić Ilija
Mrđa Vladimir
Karličić Vukojica
Bokun Radojka
Tatomirović Željka
Fluoroscence bronhoscopy
Vojnosanitetski Pregled
bronchial neoplasms
lung neoplasms
bronchoscopy
fluorescence
diagnosis
differential
sensitivity and specificity
title Fluoroscence bronhoscopy
title_full Fluoroscence bronhoscopy
title_fullStr Fluoroscence bronhoscopy
title_full_unstemmed Fluoroscence bronhoscopy
title_short Fluoroscence bronhoscopy
title_sort fluoroscence bronhoscopy
topic bronchial neoplasms
lung neoplasms
bronchoscopy
fluorescence
diagnosis
differential
sensitivity and specificity
url http://www.doiserbia.nb.rs/img/doi/0042-8450/2003/0042-84500302161T.pdf
work_keys_str_mv AT tomicilija fluoroscencebronhoscopy
AT mrđavladimir fluoroscencebronhoscopy
AT karlicicvukojica fluoroscencebronhoscopy
AT bokunradojka fluoroscencebronhoscopy
AT tatomiroviczeljka fluoroscencebronhoscopy