Neurodevelopmental domain characteristics and their association with core symptoms in preschoolers with autism spectrum disorder in China: a nationwide multicenter study
Abstract Background Autism spectrum disorder (ASD) is a group of clinically heterogenic neurodevelopmental disorders, with intellectual disability being one of its common comorbidities. No large-sample, multicenter study has focused on the neurodevelopmental aspect of preschoolers with ASD. This stu...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-022-04028-5 |
| _version_ | 1818238970151043072 |
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| author | Qian Zhang Qiu Li Ting Yang Li Chen Ying Dai Hua Wei Ke Wang Feiyong Jia Lijie Wu Yan Hao Ling Li Jie Zhang Xiaoyan Ke Mingji Yi Qi Hong Jinjin Chen Shuanfeng Fang Yichao Wang Qi Wang Chunhua Jin Jie Chen Tingyu Li |
| author_facet | Qian Zhang Qiu Li Ting Yang Li Chen Ying Dai Hua Wei Ke Wang Feiyong Jia Lijie Wu Yan Hao Ling Li Jie Zhang Xiaoyan Ke Mingji Yi Qi Hong Jinjin Chen Shuanfeng Fang Yichao Wang Qi Wang Chunhua Jin Jie Chen Tingyu Li |
| author_sort | Qian Zhang |
| collection | DOAJ |
| description | Abstract Background Autism spectrum disorder (ASD) is a group of clinically heterogenic neurodevelopmental disorders, with intellectual disability being one of its common comorbidities. No large-sample, multicenter study has focused on the neurodevelopmental aspect of preschoolers with ASD. This study investigated the neurodevelopmental characteristics of preschoolers with ASD in China and explored the association between them and the core symptoms. Methods We enrolled 1019 ASD preschoolers aged 2–7 years old from 13 cities around China between May 2018 and December 2019, and used the revised Children Neuropsychological and Behavior Scale (CNBS-R2016) to assess their neurodevelopment. Their autistic core behaviors were evaluated based on their Social Responsiveness Scale (SRS), Autism Behavior Checklist (ABC), Child Autism Rating Scale (CARS), and communication warning behavior (CWB) scores in the CNBS-R2016. Results Based on general developmental quotient (GQ) < 70, 68.4% of the preschoolers with ASD had a developmental delay (DD), rated mild in 32.7% of them. The highest DD rate (> 70%) was found in language and personal-social skills, followed by fine motor skills (68.9%). Gross motor skills had the lowest DD rate (34.0%). We found that fine motor, language, and personal-social developmental quotients (DQs) were significantly lower than gross motor skills in no DD (GQ > 70), mild DD (GQ 55–69), and moderate and below DD groups (GQ ≤ 54). Furthermore, the DQs for language and personal-social skills were significantly lower than for gross and fine motor skills in both DD groups. The ABC, SRS, CARS, and CWB scores in the no DD group were the lowest, moderate in the mild DD group, and highest in the moderate and below DD group. Besides, negative correlations were found between the DQs of the four domains and the ABC, SRS, CARS, and CWB scores, of which the language and personal-social skills DQs had the strongest correlations. Conclusions Preschoolers with ASD had unbalanced neurodevelopment domain patterns and their neurodevelopmental levels were negatively correlated with the autism core symptoms. Hence, pediatricians should actively evaluate the neurodevelopment of children with ASD and conduct long-term follow-up during their early childhood to promote early diagnosis and develop personalized intervention plans. Trial registration ChiCTR2000031194 , registered on 03/23/2020. |
| first_indexed | 2024-12-12T12:50:06Z |
| format | Article |
| id | doaj.art-0f993ee83c8c4b01983ba1ac7e7948f4 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-12T12:50:06Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-0f993ee83c8c4b01983ba1ac7e7948f42022-12-22T00:24:00ZengBMCBMC Psychiatry1471-244X2022-06-012211910.1186/s12888-022-04028-5Neurodevelopmental domain characteristics and their association with core symptoms in preschoolers with autism spectrum disorder in China: a nationwide multicenter studyQian Zhang0Qiu Li1Ting Yang2Li Chen3Ying Dai4Hua Wei5Ke Wang6Feiyong Jia7Lijie Wu8Yan Hao9Ling Li10Jie Zhang11Xiaoyan Ke12Mingji Yi13Qi Hong14Jinjin Chen15Shuanfeng Fang16Yichao Wang17Qi Wang18Chunhua Jin19Jie Chen20Tingyu Li21Department of Child Health Care, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and NutritionDepartment of Child Health Care, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and NutritionDepartment of Child Health Care, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and NutritionDepartment of Child Health Care, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and NutritionDepartment of Child Health Care, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and NutritionDepartment of Child Health Care, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and NutritionChildren’s Medical Big Data Intelligent Application Chongqing University Engineering Research Center, Children’s Hospital of Chongqing Medical UniversityDepartment of Developmental and Behavioral Pediatric, The First Hospital of Jilin UniversityDepartment of Children’s and Adolescent Health, Public Health College of Harbin Medical UniversityDepartment of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Children Rehabilitation, Hainan Women and Children’s Medical CenterXi’an Children’s HospitalChild Mental Health Research Center of Nanjing Brain HospitalDepartment of Child Health Care, The Affiliated Hospital of Qingdao UniversityMaternal and Child Health Hospital of BaoanDepartment of Child Healthcare, Shanghai Children’s Hospital, Shanghai Jiao Tong UniversityChildren’s Hospital Affiliated to Zhengzhou UniversityNHC Key Laboratory of Birth Defect for Research and Prevention, Hunan Provincial Maternal and Child Health Care HospitalDeyang Maternity & Child Healthcare HospitalDepartment of Children Health Care, Capital Institute of PediatricsDepartment of Child Health Care, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and NutritionDepartment of Child Health Care, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and NutritionAbstract Background Autism spectrum disorder (ASD) is a group of clinically heterogenic neurodevelopmental disorders, with intellectual disability being one of its common comorbidities. No large-sample, multicenter study has focused on the neurodevelopmental aspect of preschoolers with ASD. This study investigated the neurodevelopmental characteristics of preschoolers with ASD in China and explored the association between them and the core symptoms. Methods We enrolled 1019 ASD preschoolers aged 2–7 years old from 13 cities around China between May 2018 and December 2019, and used the revised Children Neuropsychological and Behavior Scale (CNBS-R2016) to assess their neurodevelopment. Their autistic core behaviors were evaluated based on their Social Responsiveness Scale (SRS), Autism Behavior Checklist (ABC), Child Autism Rating Scale (CARS), and communication warning behavior (CWB) scores in the CNBS-R2016. Results Based on general developmental quotient (GQ) < 70, 68.4% of the preschoolers with ASD had a developmental delay (DD), rated mild in 32.7% of them. The highest DD rate (> 70%) was found in language and personal-social skills, followed by fine motor skills (68.9%). Gross motor skills had the lowest DD rate (34.0%). We found that fine motor, language, and personal-social developmental quotients (DQs) were significantly lower than gross motor skills in no DD (GQ > 70), mild DD (GQ 55–69), and moderate and below DD groups (GQ ≤ 54). Furthermore, the DQs for language and personal-social skills were significantly lower than for gross and fine motor skills in both DD groups. The ABC, SRS, CARS, and CWB scores in the no DD group were the lowest, moderate in the mild DD group, and highest in the moderate and below DD group. Besides, negative correlations were found between the DQs of the four domains and the ABC, SRS, CARS, and CWB scores, of which the language and personal-social skills DQs had the strongest correlations. Conclusions Preschoolers with ASD had unbalanced neurodevelopment domain patterns and their neurodevelopmental levels were negatively correlated with the autism core symptoms. Hence, pediatricians should actively evaluate the neurodevelopment of children with ASD and conduct long-term follow-up during their early childhood to promote early diagnosis and develop personalized intervention plans. Trial registration ChiCTR2000031194 , registered on 03/23/2020.https://doi.org/10.1186/s12888-022-04028-5AutismPreschool childrenFunctional developmentCore symptomsMulticenter |
| spellingShingle | Qian Zhang Qiu Li Ting Yang Li Chen Ying Dai Hua Wei Ke Wang Feiyong Jia Lijie Wu Yan Hao Ling Li Jie Zhang Xiaoyan Ke Mingji Yi Qi Hong Jinjin Chen Shuanfeng Fang Yichao Wang Qi Wang Chunhua Jin Jie Chen Tingyu Li Neurodevelopmental domain characteristics and their association with core symptoms in preschoolers with autism spectrum disorder in China: a nationwide multicenter study BMC Psychiatry Autism Preschool children Functional development Core symptoms Multicenter |
| title | Neurodevelopmental domain characteristics and their association with core symptoms in preschoolers with autism spectrum disorder in China: a nationwide multicenter study |
| title_full | Neurodevelopmental domain characteristics and their association with core symptoms in preschoolers with autism spectrum disorder in China: a nationwide multicenter study |
| title_fullStr | Neurodevelopmental domain characteristics and their association with core symptoms in preschoolers with autism spectrum disorder in China: a nationwide multicenter study |
| title_full_unstemmed | Neurodevelopmental domain characteristics and their association with core symptoms in preschoolers with autism spectrum disorder in China: a nationwide multicenter study |
| title_short | Neurodevelopmental domain characteristics and their association with core symptoms in preschoolers with autism spectrum disorder in China: a nationwide multicenter study |
| title_sort | neurodevelopmental domain characteristics and their association with core symptoms in preschoolers with autism spectrum disorder in china a nationwide multicenter study |
| topic | Autism Preschool children Functional development Core symptoms Multicenter |
| url | https://doi.org/10.1186/s12888-022-04028-5 |
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