Liposomes: structure, composition, types, and clinical applications
Liposomes are now considered the most commonly used nanocarriers for various potentially active hydrophobic and hydrophilic molecules due to their high biocompatibility, biodegradability, and low immunogenicity. Liposomes also proved to enhance drug solubility and controlled distribution, as well as...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402200682X |
| _version_ | 1818554610058526720 |
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| author | Hamdi Nsairat Dima Khater Usama Sayed Fadwa Odeh Abeer Al Bawab Walhan Alshaer |
| author_facet | Hamdi Nsairat Dima Khater Usama Sayed Fadwa Odeh Abeer Al Bawab Walhan Alshaer |
| author_sort | Hamdi Nsairat |
| collection | DOAJ |
| description | Liposomes are now considered the most commonly used nanocarriers for various potentially active hydrophobic and hydrophilic molecules due to their high biocompatibility, biodegradability, and low immunogenicity. Liposomes also proved to enhance drug solubility and controlled distribution, as well as their capacity for surface modifications for targeted, prolonged, and sustained release. Based on the composition, liposomes can be considered to have evolved from conventional, long-circulating, targeted, and immune-liposomes to stimuli-responsive and actively targeted liposomes. Many liposomal-based drug delivery systems are currently clinically approved to treat several diseases, such as cancer, fungal and viral infections; more liposomes have reached advanced phases in clinical trials. This review describes liposomes structure, composition, preparation methods, and clinical applications. |
| first_indexed | 2024-12-12T09:42:14Z |
| format | Article |
| id | doaj.art-0f9af058b228476182a9f1204d5ed856 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-12T09:42:14Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-0f9af058b228476182a9f1204d5ed8562022-12-22T00:28:32ZengElsevierHeliyon2405-84402022-05-0185e09394Liposomes: structure, composition, types, and clinical applicationsHamdi Nsairat0Dima Khater1Usama Sayed2Fadwa Odeh3Abeer Al Bawab4Walhan Alshaer5Pharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, 19328, JordanDepartment of Chemistry, Faculty of Arts and Science, Applied Science Private University, Amman, JordanDepartment of Biology, The University of Jordan, Amman, 11942, JordanDepartment of Chemistry, The University of Jordan, Amman, 11942, JordanDepartment of Chemistry, The University of Jordan, Amman, 11942, Jordan; Hamdi Mango Center for Scientific Research, The University of Jordan, Amman, 11942, JordanCell Therapy Center, The University of Jordan, Amman, 11942, Jordan; Corresponding author.Liposomes are now considered the most commonly used nanocarriers for various potentially active hydrophobic and hydrophilic molecules due to their high biocompatibility, biodegradability, and low immunogenicity. Liposomes also proved to enhance drug solubility and controlled distribution, as well as their capacity for surface modifications for targeted, prolonged, and sustained release. Based on the composition, liposomes can be considered to have evolved from conventional, long-circulating, targeted, and immune-liposomes to stimuli-responsive and actively targeted liposomes. Many liposomal-based drug delivery systems are currently clinically approved to treat several diseases, such as cancer, fungal and viral infections; more liposomes have reached advanced phases in clinical trials. This review describes liposomes structure, composition, preparation methods, and clinical applications.http://www.sciencedirect.com/science/article/pii/S240584402200682XLiposomesPhospholipidsLamellarityStealth liposomesVaccinations |
| spellingShingle | Hamdi Nsairat Dima Khater Usama Sayed Fadwa Odeh Abeer Al Bawab Walhan Alshaer Liposomes: structure, composition, types, and clinical applications Heliyon Liposomes Phospholipids Lamellarity Stealth liposomes Vaccinations |
| title | Liposomes: structure, composition, types, and clinical applications |
| title_full | Liposomes: structure, composition, types, and clinical applications |
| title_fullStr | Liposomes: structure, composition, types, and clinical applications |
| title_full_unstemmed | Liposomes: structure, composition, types, and clinical applications |
| title_short | Liposomes: structure, composition, types, and clinical applications |
| title_sort | liposomes structure composition types and clinical applications |
| topic | Liposomes Phospholipids Lamellarity Stealth liposomes Vaccinations |
| url | http://www.sciencedirect.com/science/article/pii/S240584402200682X |
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