Glutamate transporters: animal models to neurologic disease
Glutamate is the primary excitatory amino acid neurotransmitter in the central nervous system and its activity is carefully modulated in the synaptic cleft by glutamate transporters. A number of glutamate transporters have been identified in the central nervous system and each has a unique physiolog...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2004-04-01
|
| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996103002729 |
| _version_ | 1819163520757923840 |
|---|---|
| author | Nicholas J Maragakis Jeffrey D Rothstein |
| author_facet | Nicholas J Maragakis Jeffrey D Rothstein |
| author_sort | Nicholas J Maragakis |
| collection | DOAJ |
| description | Glutamate is the primary excitatory amino acid neurotransmitter in the central nervous system and its activity is carefully modulated in the synaptic cleft by glutamate transporters. A number of glutamate transporters have been identified in the central nervous system and each has a unique physiologic property and distribution. Glutamate transporter dysfunction may either be an initiating event or part of a cascade leading to cellular dysfunction and ultimately cell death. Animal models of glutamate transporter dysfunction have revealed a significant role for these proteins in pathologic conditions such as neurodegenerative diseases, epilepsy, stroke, and central nervous system tumors. Recent work has focused on glutamate transporter biology in human diseases with an emphasis on how manipulation of these transporter proteins may lead to therapeutic interventions in neurologic disease. |
| first_indexed | 2024-12-22T17:45:27Z |
| format | Article |
| id | doaj.art-0f9ccccae945435fa354fe30cf0b6f82 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-22T17:45:27Z |
| publishDate | 2004-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-0f9ccccae945435fa354fe30cf0b6f822022-12-21T18:18:19ZengElsevierNeurobiology of Disease1095-953X2004-04-01153461473Glutamate transporters: animal models to neurologic diseaseNicholas J Maragakis0Jeffrey D Rothstein1Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USADepartment of Neurology, Johns Hopkins University, Baltimore, MD 21287, USAGlutamate is the primary excitatory amino acid neurotransmitter in the central nervous system and its activity is carefully modulated in the synaptic cleft by glutamate transporters. A number of glutamate transporters have been identified in the central nervous system and each has a unique physiologic property and distribution. Glutamate transporter dysfunction may either be an initiating event or part of a cascade leading to cellular dysfunction and ultimately cell death. Animal models of glutamate transporter dysfunction have revealed a significant role for these proteins in pathologic conditions such as neurodegenerative diseases, epilepsy, stroke, and central nervous system tumors. Recent work has focused on glutamate transporter biology in human diseases with an emphasis on how manipulation of these transporter proteins may lead to therapeutic interventions in neurologic disease.http://www.sciencedirect.com/science/article/pii/S0969996103002729GlutamateCentral nervous systemNeurologic diseases |
| spellingShingle | Nicholas J Maragakis Jeffrey D Rothstein Glutamate transporters: animal models to neurologic disease Neurobiology of Disease Glutamate Central nervous system Neurologic diseases |
| title | Glutamate transporters: animal models to neurologic disease |
| title_full | Glutamate transporters: animal models to neurologic disease |
| title_fullStr | Glutamate transporters: animal models to neurologic disease |
| title_full_unstemmed | Glutamate transporters: animal models to neurologic disease |
| title_short | Glutamate transporters: animal models to neurologic disease |
| title_sort | glutamate transporters animal models to neurologic disease |
| topic | Glutamate Central nervous system Neurologic diseases |
| url | http://www.sciencedirect.com/science/article/pii/S0969996103002729 |
| work_keys_str_mv | AT nicholasjmaragakis glutamatetransportersanimalmodelstoneurologicdisease AT jeffreydrothstein glutamatetransportersanimalmodelstoneurologicdisease |