Preoperative Diagnosis and Molecular Characterization of Gliomas With Liquid Biopsy and Radiogenomics
Gliomas are a heterogenous group of central nervous system tumors with different outcomes and different therapeutic needs. Glioblastoma, the most common subtype in adults, has a very poor prognosis and disabling consequences. The World Health Organization (WHO) classification specifies that the typi...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-05-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.865171/full |
| _version_ | 1811335536981311488 |
|---|---|
| author | Carmen Balana Sara Castañer Cristina Carrato Teresa Moran Assumpció Lopez-Paradís Marta Domenech Ainhoa Hernandez Josep Puig Josep Puig Josep Puig |
| author_facet | Carmen Balana Sara Castañer Cristina Carrato Teresa Moran Assumpció Lopez-Paradís Marta Domenech Ainhoa Hernandez Josep Puig Josep Puig Josep Puig |
| author_sort | Carmen Balana |
| collection | DOAJ |
| description | Gliomas are a heterogenous group of central nervous system tumors with different outcomes and different therapeutic needs. Glioblastoma, the most common subtype in adults, has a very poor prognosis and disabling consequences. The World Health Organization (WHO) classification specifies that the typing and grading of gliomas should include molecular markers. The molecular characterization of gliomas has implications for prognosis, treatment planning, and prediction of treatment response. At present, gliomas are diagnosed via tumor resection or biopsy, which are always invasive and frequently risky methods. In recent years, however, substantial advances have been made in developing different methods for the molecular characterization of tumors through the analysis of products shed in body fluids. Known as liquid biopsies, these analyses can potentially provide diagnostic and prognostic information, guidance on choice of treatment, and real-time information on tumor status. In addition, magnetic resonance imaging (MRI) is another good source of tumor data; radiomics and radiogenomics can link the imaging phenotypes to gene expression patterns and provide insights to tumor biology and underlying molecular signatures. Machine and deep learning and computational techniques can also use quantitative imaging features to non-invasively detect genetic mutations. The key molecular information obtained with liquid biopsies and radiogenomics can be useful not only in the diagnosis of gliomas but can also help predict response to specific treatments and provide guidelines for personalized medicine. In this article, we review the available data on the molecular characterization of gliomas using the non-invasive methods of liquid biopsy and MRI and suggest that these tools could be used in the future for the preoperative diagnosis of gliomas. |
| first_indexed | 2024-04-13T17:25:39Z |
| format | Article |
| id | doaj.art-0f9ce293924c47539a075523775161b8 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-13T17:25:39Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-0f9ce293924c47539a075523775161b82022-12-22T02:37:47ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-05-011310.3389/fneur.2022.865171865171Preoperative Diagnosis and Molecular Characterization of Gliomas With Liquid Biopsy and RadiogenomicsCarmen Balana0Sara Castañer1Cristina Carrato2Teresa Moran3Assumpció Lopez-Paradís4Marta Domenech5Ainhoa Hernandez6Josep Puig7Josep Puig8Josep Puig9Medical Oncology Service, Institut Català d'Oncologia Badalona (ICO), Badalona Applied Research Group in Oncology (B-ARGO Group), Institut Investigació Germans Trias i Pujol (IGTP), Barcelona, SpainDiagnostic Imaging Institute (IDI), Hospital Universitari Germans Trias I Pujol, Institut Investigació Germans Trias i Pujol (IGTP), Barcelona, SpainDepartment of Pathology, Hospital Universitari Germans Trias I Pujol, Institut Investigació Germans Trias i Pujol (IGTP), Barcelona, SpainMedical Oncology Service, Institut Català d'Oncologia Badalona (ICO), Badalona Applied Research Group in Oncology (B-ARGO Group), Institut Investigació Germans Trias i Pujol (IGTP), Barcelona, SpainMedical Oncology Service, Institut Català d'Oncologia Badalona (ICO), Badalona Applied Research Group in Oncology (B-ARGO Group), Institut Investigació Germans Trias i Pujol (IGTP), Barcelona, SpainMedical Oncology Service, Institut Català d'Oncologia Badalona (ICO), Badalona Applied Research Group in Oncology (B-ARGO Group), Institut Investigació Germans Trias i Pujol (IGTP), Barcelona, SpainMedical Oncology Service, Institut Català d'Oncologia Badalona (ICO), Badalona Applied Research Group in Oncology (B-ARGO Group), Institut Investigació Germans Trias i Pujol (IGTP), Barcelona, SpainDepartment of Radiology IDI [Girona Biomedical Research Institute] IDIBGI, Hospital Universitari Dr Josep Trueta, Girona, SpainDepartment of Medical Sciences, School of Medicine, University of Girona, Girona, SpainComparative Medicine and Bioimage of Catalonia, Institut Investigació Germans Trias i Pujol (IGTP), Barcelona, SpainGliomas are a heterogenous group of central nervous system tumors with different outcomes and different therapeutic needs. Glioblastoma, the most common subtype in adults, has a very poor prognosis and disabling consequences. The World Health Organization (WHO) classification specifies that the typing and grading of gliomas should include molecular markers. The molecular characterization of gliomas has implications for prognosis, treatment planning, and prediction of treatment response. At present, gliomas are diagnosed via tumor resection or biopsy, which are always invasive and frequently risky methods. In recent years, however, substantial advances have been made in developing different methods for the molecular characterization of tumors through the analysis of products shed in body fluids. Known as liquid biopsies, these analyses can potentially provide diagnostic and prognostic information, guidance on choice of treatment, and real-time information on tumor status. In addition, magnetic resonance imaging (MRI) is another good source of tumor data; radiomics and radiogenomics can link the imaging phenotypes to gene expression patterns and provide insights to tumor biology and underlying molecular signatures. Machine and deep learning and computational techniques can also use quantitative imaging features to non-invasively detect genetic mutations. The key molecular information obtained with liquid biopsies and radiogenomics can be useful not only in the diagnosis of gliomas but can also help predict response to specific treatments and provide guidelines for personalized medicine. In this article, we review the available data on the molecular characterization of gliomas using the non-invasive methods of liquid biopsy and MRI and suggest that these tools could be used in the future for the preoperative diagnosis of gliomas.https://www.frontiersin.org/articles/10.3389/fneur.2022.865171/fullgliomaglioblastomaradiomicsradiogenomicsliquid biopsydiagnosis |
| spellingShingle | Carmen Balana Sara Castañer Cristina Carrato Teresa Moran Assumpció Lopez-Paradís Marta Domenech Ainhoa Hernandez Josep Puig Josep Puig Josep Puig Preoperative Diagnosis and Molecular Characterization of Gliomas With Liquid Biopsy and Radiogenomics Frontiers in Neurology glioma glioblastoma radiomics radiogenomics liquid biopsy diagnosis |
| title | Preoperative Diagnosis and Molecular Characterization of Gliomas With Liquid Biopsy and Radiogenomics |
| title_full | Preoperative Diagnosis and Molecular Characterization of Gliomas With Liquid Biopsy and Radiogenomics |
| title_fullStr | Preoperative Diagnosis and Molecular Characterization of Gliomas With Liquid Biopsy and Radiogenomics |
| title_full_unstemmed | Preoperative Diagnosis and Molecular Characterization of Gliomas With Liquid Biopsy and Radiogenomics |
| title_short | Preoperative Diagnosis and Molecular Characterization of Gliomas With Liquid Biopsy and Radiogenomics |
| title_sort | preoperative diagnosis and molecular characterization of gliomas with liquid biopsy and radiogenomics |
| topic | glioma glioblastoma radiomics radiogenomics liquid biopsy diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.865171/full |
| work_keys_str_mv | AT carmenbalana preoperativediagnosisandmolecularcharacterizationofgliomaswithliquidbiopsyandradiogenomics AT saracastaner preoperativediagnosisandmolecularcharacterizationofgliomaswithliquidbiopsyandradiogenomics AT cristinacarrato preoperativediagnosisandmolecularcharacterizationofgliomaswithliquidbiopsyandradiogenomics AT teresamoran preoperativediagnosisandmolecularcharacterizationofgliomaswithliquidbiopsyandradiogenomics AT assumpciolopezparadis preoperativediagnosisandmolecularcharacterizationofgliomaswithliquidbiopsyandradiogenomics AT martadomenech preoperativediagnosisandmolecularcharacterizationofgliomaswithliquidbiopsyandradiogenomics AT ainhoahernandez preoperativediagnosisandmolecularcharacterizationofgliomaswithliquidbiopsyandradiogenomics AT joseppuig preoperativediagnosisandmolecularcharacterizationofgliomaswithliquidbiopsyandradiogenomics AT joseppuig preoperativediagnosisandmolecularcharacterizationofgliomaswithliquidbiopsyandradiogenomics AT joseppuig preoperativediagnosisandmolecularcharacterizationofgliomaswithliquidbiopsyandradiogenomics |